Entry Database : PDB / ID : 5lgs Structure visualization Downloads & linksTitle Crystal structure of mouse CARM1 in complex with ligand P2C3u ComponentsHistone-arginine methyltransferase CARM1 Polyadenylate-binding protein 1 DetailsKeywords TRANSFERASE / PROTEIN ARGININE METHYLTRANSFERASE / CATALYTIC DOMAIN / CHROMATIN REGULATOR / MRNA PROCESSING / MRNA SPLICING / NUCLEUS / S-ADENOSYL-L-METHIONINE / TRANSCRIPTION / TRANSCRIPTION REGULATIONFunction / homology Function and homology informationFunction Domain/homology Component
histone H3R26 methyltransferase activity / negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / mCRD-mediated mRNA stability complex / regulation of growth plate cartilage chondrocyte proliferation / histone H3R17 methyltransferase activity / translation activator activity / endochondral bone morphogenesis / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / CRD-mediated mRNA stabilization / histone H3R2 methyltransferase activity ... histone H3R26 methyltransferase activity / negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / mCRD-mediated mRNA stability complex / regulation of growth plate cartilage chondrocyte proliferation / histone H3R17 methyltransferase activity / translation activator activity / endochondral bone morphogenesis / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / CRD-mediated mRNA stabilization / histone H3R2 methyltransferase activity / RMTs methylate histone arginines / type I protein arginine methyltransferase / negative regulation of dendrite development / Regulation of lipid metabolism by PPARalpha / protein-arginine omega-N asymmetric methyltransferase activity / Cytoprotection by HMOX1 / protein methyltransferase activity / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / Estrogen-dependent gene expression / Deadenylation of mRNA / regulation of intracellular estrogen receptor signaling pathway / replication fork reversal / protein-arginine N-methyltransferase activity / positive regulation of cytoplasmic translation / M-decay: degradation of maternal mRNAs by maternally stored factors / poly(A) binding / regulatory ncRNA-mediated gene silencing / mRNA stabilization / poly(U) RNA binding / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / Translation initiation complex formation / histone methyltransferase activity / cell leading edge / nuclear replication fork / positive regulation of nuclear-transcribed mRNA poly(A) tail shortening / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / L13a-mediated translational silencing of Ceruloplasmin expression / positive regulation of fat cell differentiation / estrogen receptor signaling pathway / positive regulation of viral genome replication / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / nuclear receptor-mediated steroid hormone signaling pathway / protein localization to chromatin / response to cAMP / catalytic step 2 spliceosome / nuclear receptor coactivator activity / AUF1 (hnRNP D0) binds and destabilizes mRNA / mRNA 3'-UTR binding / lysine-acetylated histone binding / Regulation of expression of SLITs and ROBOs / mRNA splicing, via spliceosome / cytoplasmic stress granule / cytoplasmic ribonucleoprotein granule / RNA polymerase II transcription regulator complex / lamellipodium / methylation / cell population proliferation / transcription coactivator activity / transcription cis-regulatory region binding / ribonucleoprotein complex / chromatin remodeling / focal adhesion / mRNA binding / positive regulation of cell population proliferation / regulation of DNA-templated transcription / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / RNA binding / extracellular exosome / membrane / nucleus / cytosol / cytoplasm Similarity search - Function : / PABP, RNA recognition motif 2 / Polyadenylate binding protein, human types 1, 2, 3, 4 / Polyadenylate-binding protein/Hyperplastic disc protein / Poly-adenylate binding protein, unique domain / Poly(A)-binding protein C-terminal (PABC) domain profile. / C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. / PABC (PABP) domain / Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal ... : / PABP, RNA recognition motif 2 / Polyadenylate binding protein, human types 1, 2, 3, 4 / Polyadenylate-binding protein/Hyperplastic disc protein / Poly-adenylate binding protein, unique domain / Poly(A)-binding protein C-terminal (PABC) domain profile. / C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. / PABC (PABP) domain / Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / RNA recognition motif domain, eukaryote / RNA recognition motif / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / Distorted Sandwich / RNA-binding domain superfamily / PH-like domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homology 1,2-DIMETHOXYETHANE / DI(HYDROXYETHYL)ETHER / Chem-QVR / Polyadenylate-binding protein 1 / Histone-arginine methyltransferase CARM1 Similarity search - ComponentBiological species Mus musculus (house mouse)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.1 Å DetailsAuthors Marechal, N. / Troffer-Charlier, N. / Cura, V. / Bonnefond, L. / Cavarelli, J. CitationJournal : Proc. Natl. Acad. Sci. U.S.A. / Year : 2017Title : Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.Authors : van Haren, M.J. / Marechal, N. / Troffer-Charlier, N. / Cianciulli, A. / Sbardella, G. / Cavarelli, J. / Martin, N.I. History Deposition Jul 8, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 22, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Apr 5, 2017 Group : Database referencesRevision 1.2 Apr 12, 2017 Group : Database referencesRevision 1.3 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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