登録情報 | データベース: PDB / ID: 5ci8 |
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タイトル | Crystal structure of human Tob in complex with inhibitor fragment 1 |
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要素 | Protein Tob1 |
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キーワード | TRANSCRIPTION/INHIBITOR / Tob/BTG family / inhibitor / complex / TRANSCRIPTION-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
negative regulation of nuclear-transcribed mRNA poly(A) tail shortening / regulation of SMAD protein signal transduction / CCR4-NOT complex / negative regulation of BMP signaling pathway / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / negative regulation of osteoblast differentiation / SMAD binding / positive regulation of nuclear-transcribed mRNA poly(A) tail shortening / receptor tyrosine kinase binding / transcription corepressor activity ...negative regulation of nuclear-transcribed mRNA poly(A) tail shortening / regulation of SMAD protein signal transduction / CCR4-NOT complex / negative regulation of BMP signaling pathway / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / negative regulation of osteoblast differentiation / SMAD binding / positive regulation of nuclear-transcribed mRNA poly(A) tail shortening / receptor tyrosine kinase binding / transcription corepressor activity / regulation of gene expression / negative regulation of translation / negative regulation of cell population proliferation / nucleus / cytoplasm類似検索 - 分子機能 Tob1/2 / Anti-proliferative protein, N-terminal domain / BTG family signature 1. / BTG family signature 2. / Anti-proliferative protein / BTG-like domain superfamily / BTG family / tob/btg1 family / Actin; Chain A, domain 4 / Alpha-Beta Complex / Alpha Beta類似検索 - ドメイン・相同性 pyrrolo[1,2-a]quinoxalin-4(5H)-one / Protein Tob1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.328 Å |
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データ登録者 | Bai, Y. / Tashiro, S. / Nagatoishi, S. / Suzuki, T. / Tsumoto, K. / Bartlam, M. / Yamamoto, T. |
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資金援助 | 中国, 日本, 3件 組織 | 認可番号 | 国 |
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Ministry of Science and Technology | 2014CB560709 | 中国 | Ministry of Education, Culture, Sports, Science and Technology, Japan | | 日本 | KAKENHI | 25121734 | 日本 |
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引用 | ジャーナル: Protein Cell / 年: 2015 タイトル: Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach 著者: Bai, Y. / Tashiro, S. / Nagatoishi, S. / Suzuki, T. / Yan, D. / Liu, R. / Tsumoto, K. / Bartlam, M. / Yamamoto, T. |
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履歴 | 登録 | 2015年7月11日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2015年11月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年12月9日 | Group: Database references |
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