positive regulation of transformation of host cell by virus / regulation of fatty acid transport / enamel mineralization / positive regulation of fatty acid beta-oxidation / cellular response to fructose stimulus / regulation of ketone metabolic process / regulation of fatty acid metabolic process / negative regulation of cell growth involved in cardiac muscle cell development / negative regulation of appetite / negative regulation of hepatocyte apoptotic process ...positive regulation of transformation of host cell by virus / regulation of fatty acid transport / enamel mineralization / positive regulation of fatty acid beta-oxidation / cellular response to fructose stimulus / regulation of ketone metabolic process / regulation of fatty acid metabolic process / negative regulation of cell growth involved in cardiac muscle cell development / negative regulation of appetite / negative regulation of hepatocyte apoptotic process / lipoprotein metabolic process / positive regulation of fatty acid oxidation / behavioral response to nicotine / negative regulation of leukocyte cell-cell adhesion / labyrinthine layer morphogenesis / positive regulation of transcription from RNA polymerase II promoter by galactose / regulation of thyroid hormone receptor signaling pathway / positive regulation of female receptivity / negative regulation of glycolytic process / ubiquitin conjugating enzyme binding / mitogen-activated protein kinase kinase kinase binding / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / positive regulation of fatty acid metabolic process / male mating behavior / DNA-binding transcription activator activity / NFAT protein binding / negative regulation of cholesterol storage / hypothalamus development / positive regulation of ATP biosynthetic process / nuclear steroid receptor activity / cellular response to Thyroglobulin triiodothyronine / negative regulation of macrophage derived foam cell differentiation / Synthesis of bile acids and bile salts / progesterone receptor signaling pathway / epidermis development / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Endogenous sterols / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / response to retinoic acid / nuclear retinoid X receptor binding / phosphatase binding / estrous cycle / positive regulation of lipid biosynthetic process / Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 / histone acetyltransferase activity / cellular response to hormone stimulus / Recycling of bile acids and salts / histone acetyltransferase / intracellular receptor signaling pathway / negative regulation of blood pressure / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / nitric oxide metabolic process / hormone-mediated signaling pathway / estrogen receptor signaling pathway / negative regulation of reactive oxygen species biosynthetic process / positive regulation of adipose tissue development / : / lactation / Regulation of lipid metabolism by PPARalpha / response to nutrient / peroxisome proliferator activated receptor signaling pathway / MDM2/MDM4 family protein binding / regulation of cellular response to insulin stimulus / positive regulation of gluconeogenesis / positive regulation of neuron differentiation / negative regulation of cytokine production involved in inflammatory response / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / BMAL1:CLOCK,NPAS2 activates circadian expression / negative regulation of miRNA transcription / SUMOylation of transcription cofactors / response to progesterone / Activation of gene expression by SREBF (SREBP) / cerebellum development / cellular response to starvation / nuclear estrogen receptor binding / nuclear receptor binding / gluconeogenesis / hippocampus development / RNA polymerase II transcription regulatory region sequence-specific DNA binding / SUMOylation of intracellular receptors / negative regulation of transforming growth factor beta receptor signaling pathway / mRNA transcription by RNA polymerase II / circadian regulation of gene expression / fatty acid metabolic process / wound healing / Heme signaling / Transcriptional activation of mitochondrial biogenesis / PPARA activates gene expression / regulation of circadian rhythm / response to insulin / Cytoprotection by HMOX1 / cerebral cortex development / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway / negative regulation of inflammatory response / DNA-binding transcription repressor activity, RNA polymerase II-specific / RNA polymerase II transcription regulator complex / transcription coactivator binding / male gonad development / nuclear receptor activity Similarity search - Function
Resolution: 3.45→11 Å / Cor.coef. Fo:Fc: 0.853 / Cor.coef. Fo:Fc free: 0.74 / SU B: 40.739 / SU ML: 0.65 / Cross valid method: THROUGHOUT / ESU R Free: 0.823 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.30763
400
5.1 %
RANDOM
Rwork
0.25254
-
-
-
obs
0.25537
7408
94.46 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK