登録情報 | データベース: PDB / ID: 4zk5 |
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タイトル | MAP4K4 in complex with inhibitor GNE-495 |
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要素 | Mitogen-activated protein kinase kinase kinase kinase 4 |
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キーワード | Transferase/Transferase Inhibitor / kinase / Transferase-Transferase Inhibitor complex |
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機能・相同性 | 機能・相同性情報
positive regulation of ARF protein signal transduction / positive regulation of hippo signaling / MAP kinase kinase kinase kinase activity / creatine kinase activity / positive regulation of keratinocyte migration / positive regulation of focal adhesion disassembly / regulation of JNK cascade / negative regulation of cell-matrix adhesion / positive regulation of focal adhesion assembly / regulation of MAPK cascade ...positive regulation of ARF protein signal transduction / positive regulation of hippo signaling / MAP kinase kinase kinase kinase activity / creatine kinase activity / positive regulation of keratinocyte migration / positive regulation of focal adhesion disassembly / regulation of JNK cascade / negative regulation of cell-matrix adhesion / positive regulation of focal adhesion assembly / regulation of MAPK cascade / neuron projection morphogenesis / positive regulation of GTPase activity / MAPK cascade / microtubule binding / Oxidative Stress Induced Senescence / non-specific serine/threonine protein kinase / positive regulation of cell migration / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / focal adhesion / protein serine/threonine kinase activity / negative regulation of apoptotic process / ATP binding / cytoplasm類似検索 - 分子機能 : / Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 / CNH domain / Citron homology (CNH) domain / Citron homology (CNH) domain profile. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 ...: / Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2 / CNH domain / Citron homology (CNH) domain / Citron homology (CNH) domain profile. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-4P4 / Mitogen-activated protein kinase kinase kinase kinase 4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.89 Å |
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データ登録者 | Harris, S.F. / Wu, P. / Coons, M. |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2015 タイトル: Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. 著者: Ndubaku, C.O. / Crawford, T.D. / Chen, H. / Boggs, J.W. / Drobnick, J. / Harris, S.F. / Jesudason, R. / McNamara, E. / Nonomiya, J. / Sambrone, A. / Schmidt, S. / Smyczek, T. / Vitorino, P. / ...著者: Ndubaku, C.O. / Crawford, T.D. / Chen, H. / Boggs, J.W. / Drobnick, J. / Harris, S.F. / Jesudason, R. / McNamara, E. / Nonomiya, J. / Sambrone, A. / Schmidt, S. / Smyczek, T. / Vitorino, P. / Wang, L. / Wu, P. / Yeung, S. / Chen, J. / Chen, K. / Ding, C.Z. / Wang, T. / Xu, Z. / Gould, S.E. / Murray, L.J. / Ye, W. |
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履歴 | 登録 | 2015年4月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年9月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年7月20日 | Group: Data collection |
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改定 1.2 | 2024年3月6日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_oper_list Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation |
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