Entry | Database: PDB / ID: 4wnp |
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Title | Structure of ULK1 bound to a potent inhibitor |
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Components | Serine/threonine-protein kinase ULK1 |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / kinase / autophagy / inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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Function / homology | Function and homology information
omegasome membrane / neuron projection regeneration / regulation of protein lipidation / negative regulation of collateral sprouting / Atg1/ULK1 kinase complex / positive regulation of autophagosome assembly / phagophore assembly site membrane / piecemeal microautophagy of the nucleus / RAB GEFs exchange GTP for GDP on RABs / regulation of tumor necrosis factor-mediated signaling pathway ...omegasome membrane / neuron projection regeneration / regulation of protein lipidation / negative regulation of collateral sprouting / Atg1/ULK1 kinase complex / positive regulation of autophagosome assembly / phagophore assembly site membrane / piecemeal microautophagy of the nucleus / RAB GEFs exchange GTP for GDP on RABs / regulation of tumor necrosis factor-mediated signaling pathway / axon extension / phagophore assembly site / autophagy of mitochondrion / TBC/RABGAPs / reticulophagy / Receptor Mediated Mitophagy / Macroautophagy / response to starvation / autophagosome membrane / autophagosome assembly / regulation of macroautophagy / cellular response to nutrient levels / negative regulation of protein-containing complex assembly / positive regulation of autophagy / autophagosome / macroautophagy / Regulation of TNFR1 signaling / peptidyl-threonine phosphorylation / recycling endosome / small GTPase binding / autophagy / neuron projection development / protein localization / GTPase binding / peptidyl-serine phosphorylation / mitochondrial outer membrane / protein autophosphorylation / non-specific serine/threonine protein kinase / protein phosphorylation / negative regulation of cell population proliferation / axon / protein serine kinase activity / protein serine/threonine kinase activity / endoplasmic reticulum membrane / protein-containing complex binding / signal transduction / ATP binding / identical protein binding / cytosol / cytoplasmSimilarity search - Function Serine/threonine-protein kinase, Ulk1/Ulk2 / : / ATG1-like, MIT domain 2 / Serine/threonine-protein kinase Atg1-like, tMIT domain / Atg1-like, MIT domain 1 / Serine/threonine-protein kinase Atg1-like / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 ...Serine/threonine-protein kinase, Ulk1/Ulk2 / : / ATG1-like, MIT domain 2 / Serine/threonine-protein kinase Atg1-like, tMIT domain / Atg1-like, MIT domain 1 / Serine/threonine-protein kinase Atg1-like / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.88 Å |
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Authors | Lazarus, M.B. / Novotny, C.J. / Shokat, K.M. |
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Citation | Journal: Acs Chem.Biol. / Year: 2015 Title: Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors. Authors: Lazarus, M.B. / Novotny, C.J. / Shokat, K.M. |
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History | Deposition | Oct 14, 2014 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jan 14, 2015 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 28, 2015 | Group: Database references |
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Revision 1.2 | Nov 22, 2017 | Group: Derived calculations / Other ...Derived calculations / Other / Refinement description / Source and taxonomy / Structure summary Category: entity_src_gen / pdbx_database_status ...entity_src_gen / pdbx_database_status / pdbx_struct_oper_list / software / struct_keywords Item: _entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible ..._entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_oper_list.symmetry_operation / _software.classification / _software.name / _struct_keywords.text |
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Revision 1.3 | Dec 27, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / refine_hist Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _refine_hist.number_atoms_total / _refine_hist.pdbx_number_atoms_nucleic_acid / _refine_hist.pdbx_number_atoms_protein |
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