Entry Database : PDB / ID : 4rk8 Structure visualization Downloads & linksTitle Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356 ComponentsDihydroorotate dehydrogenase (quinone), mitochondrial Details Keywords Oxidoreductase/Oxidoreductase inhibitor / oxidoreductase / FMN binding / mitochondria inner membrane / Oxidoreductase-Oxidoreductase inhibitor complexFunction / homology Function and homology informationFunction Domain/homology Component
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ... pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / plasma membrane / cytosol Similarity search - Function Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.22 Å DetailsAuthors Zhu, L. / Ren, X. / Zhu, J. / Li, H. CitationJournal : TO BE PUBLISHED Title : Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356Authors : Zhu, L. / Ren, X. / Zhu, J. / Li, H. History Deposition Oct 12, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 11, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Show all Show less