登録情報 | データベース: PDB / ID: 4mnx |
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タイトル | Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK811 |
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要素 | - Urokinase-type plasminogen activator chain B
- bicyclic peptide UK811
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / competitive inhibitor (競合阻害) / bicyclic peptide / inhibitor (酵素阻害剤) / protease (プロテアーゼ) / 1 / 1' / 1''-(1 / 3 / 5-triazinane-1 / 5-triyl)triprop-2-en-1-one (TATA) cyclization / extracellular / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
ウロキナーゼ / regulation of smooth muscle cell-matrix adhesion / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / regulation of fibrinolysis / regulation of wound healing / protein complex involved in cell-matrix adhesion / negative regulation of plasminogen activation / regulation of smooth muscle cell migration / regulation of signaling receptor activity ...ウロキナーゼ / regulation of smooth muscle cell-matrix adhesion / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / regulation of fibrinolysis / regulation of wound healing / protein complex involved in cell-matrix adhesion / negative regulation of plasminogen activation / regulation of smooth muscle cell migration / regulation of signaling receptor activity / serine-type endopeptidase complex / Dissolution of Fibrin Clot / smooth muscle cell migration / plasminogen activation / regulation of cell adhesion mediated by integrin / tertiary granule membrane / negative regulation of fibrinolysis / regulation of cell adhesion / specific granule membrane / serine protease inhibitor complex / fibrinolysis / 走化性 / 凝固・線溶系 / regulation of cell population proliferation / response to hypoxia / positive regulation of cell migration / external side of plasma membrane / serine-type endopeptidase activity / focal adhesion / Neutrophil degranulation / 細胞膜 / シグナル伝達 / タンパク質分解 / extracellular space / extracellular exosome / extracellular region / 細胞膜類似検索 - 分子機能 Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / EGF-like domain profile. / EGF-like domain signature 1. ...Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / EGF-like domain profile. / EGF-like domain signature 1. / EGF様ドメイン / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / トリプシン / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Βバレル / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.85 Å |
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データ登録者 | Chen, S. / Pojer, F. / Heinis, C. |
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引用 | ジャーナル: Angew.Chem.Int.Ed.Engl. / 年: 2014 タイトル: Peptide ligands stabilized by small molecules. 著者: Chen, S. / Bertoldo, D. / Angelini, A. / Pojer, F. / Heinis, C. |
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履歴 | 登録 | 2013年9月11日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年2月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年2月26日 | Group: Database references |
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改定 1.2 | 2017年11月15日 | Group: Refinement description / カテゴリ: software |
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