Entry Database : PDB / ID : 4jwx Structure visualization Downloads & linksTitle GluN2A ligand-binding core in complex with propyl-NHP5G ComponentsGluN2A Details Keywords UNKNOWN FUNCTION / bilobed structureFunction / homology Function and homology informationFunction Domain/homology Component
neurotransmitter receptor transport, plasma membrane to endosome / regulation of response to alcohol / response to ammonium ion / receptor recycling / directional locomotion / response to environmental enrichment / Assembly and cell surface presentation of NMDA receptors / response to hydrogen sulfide / serotonin metabolic process / conditioned place preference ... neurotransmitter receptor transport, plasma membrane to endosome / regulation of response to alcohol / response to ammonium ion / receptor recycling / directional locomotion / response to environmental enrichment / Assembly and cell surface presentation of NMDA receptors / response to hydrogen sulfide / serotonin metabolic process / conditioned place preference / protein localization to postsynaptic membrane / response to other organism / positive regulation of inhibitory postsynaptic potential / regulation of ARF protein signal transduction / cellular response to magnesium ion / response to methylmercury / voltage-gated monoatomic cation channel activity / sleep / cellular response to dsRNA / dendritic spine organization / response to carbohydrate / regulation of monoatomic cation transmembrane transport / cellular response to lipid / locomotion / NMDA glutamate receptor activity / Synaptic adhesion-like molecules / NMDA selective glutamate receptor complex / regulation of NMDA receptor activity / glutamate-gated calcium ion channel activity / parallel fiber to Purkinje cell synapse / response to manganese ion / calcium ion transmembrane import into cytosol / glutamate binding / cellular response to zinc ion / action potential / spinal cord development / dopamine metabolic process / startle response / response to amine / monoatomic cation transmembrane transport / regulation of neuronal synaptic plasticity / modulation of excitatory postsynaptic potential / response to lithium ion / positive regulation of excitatory postsynaptic potential / cellular response to glycine / response to light stimulus / positive regulation of protein targeting to membrane / neuron development / Unblocking of NMDA receptors, glutamate binding and activation / regulation of postsynaptic membrane potential / postsynaptic density, intracellular component / cellular response to manganese ion / glutamate receptor binding / multicellular organismal response to stress / monoatomic cation channel activity / glutamate-gated receptor activity / response to fungicide / sensory perception of pain / cell adhesion molecule binding / dendrite membrane / ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential / response to amphetamine / ionotropic glutamate receptor signaling pathway / excitatory postsynaptic potential / positive regulation of synaptic transmission, glutamatergic / neurogenesis / protein tyrosine kinase binding / response to cocaine / learning / synaptic membrane / synaptic transmission, glutamatergic / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / regulation of membrane potential / hippocampus development / long-term synaptic potentiation / cellular response to amino acid stimulus / postsynaptic density membrane / regulation of long-term neuronal synaptic plasticity / response to nicotine / protein catabolic process / calcium channel activity / visual learning / modulation of chemical synaptic transmission / regulation of synaptic plasticity / cytoplasmic vesicle membrane / negative regulation of protein catabolic process / response to organic cyclic compound / terminal bouton / cerebral cortex development / memory / cellular response to growth factor stimulus / response to wounding / response to calcium ion / calcium ion transport / calcium-dependent protein binding / rhythmic process / synaptic vesicle / presynaptic membrane / ATPase binding / scaffold protein binding Similarity search - Function Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site ... Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / Periplasmic binding protein-like II / Periplasmic binding protein-like I / D-Maltodextrin-Binding Protein; domain 2 / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.5 Å DetailsAuthors Hansen, K.B. / Tajima, N. / Risgaard, R. / Perszyk, R.E. / Jorgensen, L. / Vance, K.M. / Ogden, K.K. / Clausen, R.P. / Furukawa, H. / Traynelis, S.F. CitationJournal : Mol.Pharmacol. / Year : 2013Title : Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors.Authors : Hansen, K.B. / Tajima, N. / Risgaard, R. / Perszyk, R.E. / Jorgensen, L. / Vance, K.M. / Ogden, K.K. / Clausen, R.P. / Furukawa, H. / Traynelis, S.F. History Deposition Mar 27, 2013 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 29, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Jul 17, 2013 Group : Database referencesRevision 1.2 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Show all Show less