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Structure paper

TitleStructural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors.
Journal, issue, pagesMol. Pharmacol., Vol. 84, Page 114-127, Year 2013
Publish dateMar 27, 2013 (structure data deposition date)
AuthorsHansen, K.B. / Tajima, N. / Risgaard, R. / Perszyk, R.E. / Jorgensen, L. / Vance, K.M. / Ogden, K.K. / Clausen, R.P. / Furukawa, H. / Traynelis, S.F.
External linksMol. Pharmacol. / PubMed:23625947
MethodsX-ray diffraction
Resolution1.5 - 2 Å
Structure data

PDB-4jwx:
GluN2A ligand-binding core in complex with propyl-NHP5G
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-4jwy:
GluN2D ligand-binding core in complex with propyl-NHP5G
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-1N4:
(2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsUNKNOWN FUNCTION / bilobed structure / TRANSPORT PROTEIN / ion channel

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