登録情報 | データベース: PDB / ID: 4esi |
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タイトル | Structure of ricin A chain bound with N-((1H-1,2,3-triazol-4-yl)methyl-2-amino-4-oxo-3,4-dihydropteridine-7-carboxamide |
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要素 | Ricin |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / RICIN / TOXIN / PROTEIN-LIGAND COMPLEX / HYDROLASE / RIBOSOME INACTIVATING PROTEIN / N-GLYCOSIDASE / PTERIN / HYDROLASE-INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
rRNA N-glycosylase / rRNA N-glycosylase activity / AMP binding / defense response / toxin activity / carbohydrate binding / killing of cells of another organism / negative regulation of translation類似検索 - 分子機能 Ricin (A Subunit), domain 2 / Ricin (A Subunit), domain 2 / Ricin (A subunit); domain 1 / Ricin (A subunit), domain 1 / Ribosome-inactivating protein conserved site / Shiga/ricin ribosomal inactivating toxins active site signature. / Ricin-type beta-trefoil lectin domain / Ribosome-inactivating protein type 1/2 / Ribosome-inactivating protein / Ribosome-inactivating protein, subdomain 1 ...Ricin (A Subunit), domain 2 / Ricin (A Subunit), domain 2 / Ricin (A subunit); domain 1 / Ricin (A subunit), domain 1 / Ribosome-inactivating protein conserved site / Shiga/ricin ribosomal inactivating toxins active site signature. / Ricin-type beta-trefoil lectin domain / Ribosome-inactivating protein type 1/2 / Ribosome-inactivating protein / Ribosome-inactivating protein, subdomain 1 / Ribosome-inactivating protein, subdomain 2 / Ribosome-inactivating protein superfamily / Ribosome inactivating protein / Ricin-type beta-trefoil / Lectin domain of ricin B chain profile. / Ricin B, lectin domain / Ricin B-like lectins / Few Secondary Structures / Irregular / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Ricinus communis (トウゴマ) |
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手法 | X線回折 / 分子置換 / 解像度: 1.87 Å |
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データ登録者 | Jasheway, K.R. / Pruet, J.M. / Ryoto, S. / Manzano, L.A. / Wiget, P.A. / Kamat, I. / Anslyn, E.V. / Monzingo, A.F. / Robertus, J.D. |
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引用 | ジャーナル: ACS Med Chem Lett / 年: 2012 タイトル: Optimized 5-membered heterocycle-linked pterins for the inhibition of Ricin Toxin A. 著者: Pruet, J.M. / Saito, R. / Manzano, L.A. / Jasheway, K.R. / Wiget, P.A. / Kamat, I. / Anslyn, E.V. / Robertus, J.D. |
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履歴 | 登録 | 2012年4月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年10月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年11月15日 | Group: Refinement description / カテゴリ: software Item: _software.classification / _software.contact_author ..._software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version |
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改定 1.2 | 2023年9月13日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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