登録情報 データベース : PDB / ID : 4b99 構造の表示 ダウンロードとリンクタイトル Crystal Structure of MAPK7 (ERK5) with inhibitor 要素MITOGEN-ACTIVATED PROTEIN KINASE 7 詳細 キーワード TRANSFERASE / INHIBITOR機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Signalling to ERK5 / negative regulation of response to cytokine stimulus / negative regulation of heterotypic cell-cell adhesion / calcineurin-NFAT signaling cascade / cellular response to laminar fluid shear stress / Gastrin-CREB signalling pathway via PKC and MAPK / ERKs are inactivated / enzyme inhibitor activity / mitogen-activated protein kinase binding / negative regulation of calcineurin-NFAT signaling cascade ... Signalling to ERK5 / negative regulation of response to cytokine stimulus / negative regulation of heterotypic cell-cell adhesion / calcineurin-NFAT signaling cascade / cellular response to laminar fluid shear stress / Gastrin-CREB signalling pathway via PKC and MAPK / ERKs are inactivated / enzyme inhibitor activity / mitogen-activated protein kinase binding / negative regulation of calcineurin-NFAT signaling cascade / ERK/MAPK targets / negative regulation of smooth muscle cell apoptotic process / RET signaling / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / MAP kinase activity / mitogen-activated protein kinase / regulation of angiogenesis / negative regulation of endothelial cell apoptotic process / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / cellular response to transforming growth factor beta stimulus / positive regulation of protein metabolic process / adenylate cyclase-activating G protein-coupled receptor signaling pathway / cellular response to growth factor stimulus / PML body / negative regulation of inflammatory response / cellular response to hydrogen peroxide / MAPK cascade / Senescence-Associated Secretory Phenotype (SASP) / cell differentiation / intracellular signal transduction / protein serine kinase activity / protein serine/threonine kinase activity / signal transduction / positive regulation of transcription by RNA polymerase II / nucleoplasm / ATP binding / nucleus / cytosol / cytoplasm 類似検索 - 分子機能 Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain ... Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-R4L / Mitogen-activated protein kinase 7 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.8 Å 詳細データ登録者 Elkins, J.M. / Wang, J. / Vollmar, M. / Mahajan, P. / Savitsky, P. / Deng, X. / Gray, N.S. / Pike, A.C.W. / von Delft, F. / Bountra, C. ...Elkins, J.M. / Wang, J. / Vollmar, M. / Mahajan, P. / Savitsky, P. / Deng, X. / Gray, N.S. / Pike, A.C.W. / von Delft, F. / Bountra, C. / Arrowsmith, C. / Edwards, A. / Knapp, S. 引用ジャーナル : J.Med.Chem. / 年 : 2013タイトル : X-Ray Crystal Structure of Erk5 (Mapk7) in Complex with a Specific Inhibitor.著者 : Elkins, J.M. / Wang, J. / Deng, X. / Pattison, M.J. / Arthur, S. / Erazo, T. / Gomez, N. / Lizcano, J.M. / Gray, N.S. / Knapp, S. 履歴 登録 2012年9月3日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2012年9月19日 Provider : repository / タイプ : Initial release改定 1.1 2013年5月22日 Group : Database references改定 1.2 2013年6月26日 Group : Database references改定 1.3 2018年1月24日 Group : Structure summary / カテゴリ : audit_author / Item : _audit_author.name改定 1.4 2023年12月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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