登録情報 | データベース: EMDB / ID: EMD-41496 |
---|
タイトル | Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: trans-oriented 1B2 and ACP |
---|
マップデータ | |
---|
試料 | - 複合体: Crosslinked DEBS Module 3 in complex with Antibody Fragment 1B2
- タンパク質・ペプチド: EryAII,EryAII,EryAII,6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
- タンパク質・ペプチド: Antibody Fragment 1B2, Heavy Chain
- タンパク質・ペプチド: Antibody Fragment 1B2, Light Chain
|
---|
キーワード | polyketide synthase / antibody / BIOSYNTHETIC PROTEIN |
---|
機能・相同性 | 機能・相同性情報
macrolide biosynthetic process / DIM/DIP cell wall layer assembly / fatty acid synthase activity / phosphopantetheine binding / 3-oxoacyl-[acyl-carrier-protein] synthase activity / fatty acid biosynthetic process / oxidoreductase activity / plasma membrane / cytoplasm類似検索 - 分子機能 Erythronolide synthase, docking / Erythronolide synthase, docking domain superfamily / Erythronolide synthase, docking / Zinc-binding dehydrogenase / Polyketide synthase, docking domain / Erythronolide synthase docking domain / : / : / Polyketide synthase dehydratase domain / : ...Erythronolide synthase, docking / Erythronolide synthase, docking domain superfamily / Erythronolide synthase, docking / Zinc-binding dehydrogenase / Polyketide synthase, docking domain / Erythronolide synthase docking domain / : / : / Polyketide synthase dehydratase domain / : / Polyketide and metazoan fatty acid synthase dehydratase (PKS/mFAS DH) domain profile. / PKS_PP_betabranch / Polyketide synthase dehydratase N-terminal domain / PKS_DH / Polyketide synthase, dehydratase domain / Polyketide synthase, dehydratase domain superfamily / Polyketide synthase, ketoreductase domain / KR domain / Malonyl-CoA ACP transacylase, ACP-binding / Polyketide synthase, C-terminal extension / Ketoacyl-synthetase C-terminal extension / PKS_KR / Acyl transferase domain superfamily / Acyl transferase / Acyl transferase domain / Acyl transferase domain in polyketide synthase (PKS) enzymes. / Acyl transferase/acyl hydrolase/lysophospholipase / Alcohol dehydrogenase, N-terminal / Alcohol dehydrogenase GroES-like domain / Polyketide synthase, enoylreductase domain / Enoylreductase / Ketosynthase family 3 (KS3) domain profile. / Polyketide synthase, phosphopantetheine-binding domain / Phosphopantetheine attachment site / Beta-ketoacyl synthase / Beta-ketoacyl synthase, active site / Ketosynthase family 3 (KS3) active site signature. / Polyketide synthase, beta-ketoacyl synthase domain / Beta-ketoacyl synthase, N-terminal / Beta-ketoacyl synthase, C-terminal / Beta-ketoacyl synthase, N-terminal domain / Beta-ketoacyl synthase, C-terminal domain / GroES-like superfamily / Thiolase-like / Phosphopantetheine attachment site / Phosphopantetheine attachment site. / Phosphopantetheine attachment site / ACP-like superfamily / Carrier protein (CP) domain profile. / Phosphopantetheine binding ACP domain / NAD(P)-binding domain superfamily類似検索 - ドメイン・相同性 |
---|
生物種 | Saccharopolyspora erythraea (バクテリア) / Homo sapiens (ヒト) |
---|
手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.4 Å |
---|
データ登録者 | Cogan DP / Soohoo AM / Chen M / Brodsky KL / Liu Y / Khosla C |
---|
資金援助 | 米国, 4件 Organization | Grant number | 国 |
---|
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM141799 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM136039 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM129541 | 米国 | National Science Foundation (NSF, United States) | DGE-1656518 | 米国 |
|
---|
引用 | ジャーナル: To Be Published タイトル: Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis 著者: Cogan DP / Soohoo AM / Chen M / Liu Y / Brodsky KL / Khosla C |
---|
履歴 | 登録 | 2023年8月5日 | - |
---|
ヘッダ(付随情報) 公開 | 2024年8月7日 | - |
---|
マップ公開 | 2024年8月7日 | - |
---|
更新 | 2024年8月7日 | - |
---|
現状 | 2024年8月7日 | 処理サイト: RCSB / 状態: 公開 |
---|
|
---|