登録情報 | データベース: PDB / ID: 3oob |
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タイトル | Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate |
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要素 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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キーワード | ISOMERASE / WW domain-like peptidyl prolyl isomerase / phosphorylation-dependent cis/trans isomerase / proteins with pSer/pThr-Pro motif |
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機能・相同性 | 機能・相同性情報
cis-trans isomerase activity / phosphothreonine residue binding / negative regulation of SMAD protein signal transduction / negative regulation of cell motility / ubiquitin ligase activator activity / regulation of protein localization to nucleus / GTPase activating protein binding / mitogen-activated protein kinase kinase binding / regulation of mitotic nuclear division / postsynaptic cytosol ...cis-trans isomerase activity / phosphothreonine residue binding / negative regulation of SMAD protein signal transduction / negative regulation of cell motility / ubiquitin ligase activator activity / regulation of protein localization to nucleus / GTPase activating protein binding / mitogen-activated protein kinase kinase binding / regulation of mitotic nuclear division / postsynaptic cytosol / PI5P Regulates TP53 Acetylation / negative regulation of amyloid-beta formation / cytoskeletal motor activity / protein peptidyl-prolyl isomerization / phosphoserine residue binding / RHO GTPases Activate NADPH Oxidases / : / negative regulation of transforming growth factor beta receptor signaling pathway / ciliary basal body / positive regulation of GTPase activity / regulation of cytokinesis / negative regulation of protein binding / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / negative regulation of protein catabolic process / Negative regulators of DDX58/IFIH1 signaling / phosphoprotein binding / synapse organization / regulation of protein phosphorylation / regulation of protein stability / tau protein binding / neuron differentiation / negative regulation of ERK1 and ERK2 cascade / ISG15 antiviral mechanism / beta-catenin binding / positive regulation of canonical Wnt signaling pathway / positive regulation of protein binding / regulation of gene expression / midbody / Regulation of TP53 Activity through Phosphorylation / response to hypoxia / protein stabilization / nuclear speck / positive regulation of protein phosphorylation / glutamatergic synapse / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Ubiquitin Ligase Nedd4; Chain: W; - #10 / Ubiquitin Ligase Nedd4; Chain: W; / : / Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site / PpiC-type peptidyl-prolyl cis-trans isomerase signature. / PPIC-type PPIASE domain / PpiC-type peptidyl-prolyl cis-trans isomerase family profile. / Peptidyl-prolyl cis-trans isomerase, PpiC-type / Chitinase A; domain 3 - #40 / WW domain ...Ubiquitin Ligase Nedd4; Chain: W; - #10 / Ubiquitin Ligase Nedd4; Chain: W; / : / Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site / PpiC-type peptidyl-prolyl cis-trans isomerase signature. / PPIC-type PPIASE domain / PpiC-type peptidyl-prolyl cis-trans isomerase family profile. / Peptidyl-prolyl cis-trans isomerase, PpiC-type / Chitinase A; domain 3 - #40 / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / Chitinase A; domain 3 / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / Peptidyl-prolyl cis-trans isomerase domain superfamily / Single Sheet / Roll / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 Chem-KDH / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.89 Å |
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データ登録者 | Urusova, D.V. / Shim, J.-H. / Kim, D.-J. / Jung, S.K. / Zykova, T.A. / Bode, A.M. / Dong, Z. |
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引用 | ジャーナル: Cancer Prev Res (Phila) / 年: 2011 タイトル: Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1. 著者: Urusova, D.V. / Shim, J.H. / Kim, D.J. / Jung, S.K. / Zykova, T.A. / Carper, A. / Bode, A.M. / Dong, Z. |
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履歴 | 登録 | 2010年8月30日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2011年8月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年8月24日 | Group: Other |
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改定 1.2 | 2011年11月30日 | Group: Database references |
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改定 1.3 | 2017年11月8日 | Group: Refinement description / カテゴリ: software |
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改定 1.4 | 2024年2月21日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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