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- PDB-3ig7: Novel CDK-5 inhibitors - crystal structure of inhibitor EFP with CDK-2 -
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Open data
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Basic information
Entry | Database: PDB / ID: 3ig7 | ||||||
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Title | Novel CDK-5 inhibitors - crystal structure of inhibitor EFP with CDK-2 | ||||||
![]() | Cell division protein kinase 2![]() | ||||||
![]() | ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() | ||||||
Function / homology | ![]() cyclin A1-CDK2 complex / cyclin E2-CDK2 complex / cyclin E1-CDK2 complex / cyclin A2-CDK2 complex / positive regulation of DNA-templated DNA replication initiation / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Pandit, J. | ||||||
![]() | ![]() Title: Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease. Authors: Helal, C.J. / Kang, Z. / Lucas, J.C. / Gant, T. / Ahlijanian, M.K. / Schachter, J.B. / Richter, K.E. / Cook, J.M. / Menniti, F.S. / Kelly, K. / Mente, S. / Pandit, J. / Hosea, N. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 66.2 KB | Display | ![]() |
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PDB format | ![]() | 52.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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1 |
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Unit cell |
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Components
#1: Protein | ![]() Mass: 34002.527 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() ![]() |
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#2: Chemical | ChemComp-EFP / |
#3: Water | ChemComp-HOH / ![]() |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2 Å3/Da / Density % sol: 38.53 % |
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-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() |
Detector | Type: RIGAKU RAXIS II / Detector: IMAGE PLATE |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 1.8→50 Å / Num. all: 25951 / Num. obs: 25483 / % possible obs: 98.2 % / Observed criterion σ(I): -2 / Redundancy: 3.3 % / Rmerge(I) obs: 0.063 / Rsym value: 0.063 / Net I/σ(I): 17.05 |
Reflection shell | Resolution: 1.8→1.86 Å / Rmerge(I) obs: 0.697 / Mean I/σ(I) obs: 1.66 / Num. unique all: 2478 / % possible all: 97.4 |
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Processing
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Refinement | Method to determine structure![]() ![]()
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Displacement parameters | Biso max: 99.23 Å2 / Biso mean: 33.199 Å2 / Biso min: 12.29 Å2 | |||||||||||||||
Refinement step | Cycle: LAST / Resolution: 1.8→36.67 Å
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