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TitlePotent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 5703-5707, Year 2009
Publish dateJul 27, 2009 (structure data deposition date)
AuthorsHelal, C.J. / Kang, Z. / Lucas, J.C. / Gant, T. / Ahlijanian, M.K. / Schachter, J.B. / Richter, K.E. / Cook, J.M. / Menniti, F.S. / Kelly, K. ...Helal, C.J. / Kang, Z. / Lucas, J.C. / Gant, T. / Ahlijanian, M.K. / Schachter, J.B. / Richter, K.E. / Cook, J.M. / Menniti, F.S. / Kelly, K. / Mente, S. / Pandit, J. / Hosea, N.
External linksBioorg. Med. Chem. Lett. / PubMed:19700321
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3ig7:
Novel CDK-5 inhibitors - crystal structure of inhibitor EFP with CDK-2
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3igg:
Novel CDK-5 inhibitors - crystal structure of inhibitor EFQ with CDK-2
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-EFP:
N-{1-[cis-3-(acetylamino)cyclobutyl]-1H-imidazol-4-yl}-2-(4-methoxyphenyl)acetamide

ChemComp-HOH:
WATER

ChemComp-EFQ:
N-[1-(cis-3-hydroxycyclobutyl)-1H-imidazol-4-yl]-2-(4-methoxyphenyl)acetamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PROTEIN KINASE / SERINE/THREONINE PROTEIN KINASE / ATP-BINDING / CELL CYCLE / CELL DIVISION / MITOSIS / 4-AMINOIMIDAZOLE / Kinase / Nucleotide-binding / Phosphoprotein / Polymorphism / Serine/threonine-protein kinase / INHIBITOR

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