- PDB-3hpt: Crystal structure of human FxA in complex with (S)-2-cyano-1-(2-m... -
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Database: PDB / ID: 3hpt
Title
Crystal structure of human FxA in complex with (S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine
coagulation factor Xa / Defective factor IX causes thrombophilia / Defective cofactor function of FVIIIa variant / Defective F9 variant does not activate FX / Extrinsic Pathway of Fibrin Clot Formation / positive regulation of TOR signaling / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Common Pathway of Fibrin Clot Formation / Removal of aminoterminal propeptides from gamma-carboxylated proteins ...coagulation factor Xa / Defective factor IX causes thrombophilia / Defective cofactor function of FVIIIa variant / Defective F9 variant does not activate FX / Extrinsic Pathway of Fibrin Clot Formation / positive regulation of TOR signaling / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Common Pathway of Fibrin Clot Formation / Removal of aminoterminal propeptides from gamma-carboxylated proteins / Intrinsic Pathway of Fibrin Clot Formation / phospholipid binding / Golgi lumen / blood coagulation / positive regulation of cell migration / endoplasmic reticulum lumen / external side of plasma membrane / serine-type endopeptidase activity / calcium ion binding / proteolysis / extracellular space / extracellular region / plasma membrane Similarity search - Function
THE BIOLOGICAL UNIT CONSISTS OF ONE LIGHT CHAIN (EGF-LIKE DOMAIN) AND ONE HEAVY CHAIN (CATALYTIC DOMAIN). THE ASYMMETRIC UNIT CONTAINS TWO BIOLOGICAL UNITS (CHAINS A,B AND CHAINS C,D). CHAINS A AND C ARE EGF-LIKE DOMAINS. CHAINS B AND D ARE CATALYTIC DOMAINS.
CoagulationfactorX / Stuart factor / Stuart-Prower factor / Factor X light chain
Mass: 10213.346 Da / Num. of mol.: 2 / Fragment: Factor X light chain: UNP residues 85-178 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / Tissue: Blood / References: UniProt: P00742, coagulation factor Xa
#2: Protein
CoagulationfactorX / Stuart factor / Stuart-Prower factor / Activated factor Xa heavy chain
Mass: 26871.623 Da / Num. of mol.: 2 Fragment: Activated factor Xa heavy chain: UNP residues 235-472 Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / Tissue: Blood / References: UniProt: P00742, coagulation factor Xa
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