Entry Database : PDB / ID : 2rjp Structure visualization Downloads & linksTitle Crystal structure of ADAMTS4 with inhibitor bound ComponentsADAMTS-4 Details Keywords HYDROLASE / metalloprotease domain / aggrecanase / Cleavage on pair of basic residues / Extracellular matrix / Glycoprotein / Metal-binding / Polymorphism / Secreted / Zinc / ZymogenFunction / homology Function and homology informationFunction Domain/homology Component
ADAMTS-4 endopeptidase / Defective B3GALTL causes PpS / O-glycosylation of TSR domain-containing proteins / extracellular matrix disassembly / Degradation of the extracellular matrix / extracellular matrix / extracellular matrix organization / skeletal system development / metalloendopeptidase activity / metallopeptidase activity ... ADAMTS-4 endopeptidase / Defective B3GALTL causes PpS / O-glycosylation of TSR domain-containing proteins / extracellular matrix disassembly / Degradation of the extracellular matrix / extracellular matrix / extracellular matrix organization / skeletal system development / metalloendopeptidase activity / metallopeptidase activity / peptidase activity / protease binding / collagen-containing extracellular matrix / nuclear speck / proteolysis / extracellular space / zinc ion binding / extracellular region Similarity search - Function YefM-like fold - #60 / ADAMTS/ADAMTS-like, Spacer 1 / ADAMTS/ADAMTS-like / ADAMTS, cysteine-rich domain 2 / ADAMTS/ADAMTS-like, cysteine-rich domain 3 / : / ADAM-TS Spacer 1 / ADAMTS cysteine-rich domain 2 / ADAMTS cysteine-rich domain / YefM-like fold ... YefM-like fold - #60 / ADAMTS/ADAMTS-like, Spacer 1 / ADAMTS/ADAMTS-like / ADAMTS, cysteine-rich domain 2 / ADAMTS/ADAMTS-like, cysteine-rich domain 3 / : / ADAM-TS Spacer 1 / ADAMTS cysteine-rich domain 2 / ADAMTS cysteine-rich domain / YefM-like fold / ADAM, cysteine-rich domain / ADAM Cysteine-Rich Domain / Reprolysin (M12B) family zinc metalloprotease / Peptidase M12B, ADAM/reprolysin / ADAM type metalloprotease domain profile. / Thrombospondin type 1 domain / Thrombospondin type-1 (TSP1) repeat superfamily / Thrombospondin type-1 (TSP1) repeat profile. / Thrombospondin type 1 repeats / Thrombospondin type-1 (TSP1) repeat / Collagenase (Catalytic Domain) / Collagenase (Catalytic Domain) / Metallopeptidase, catalytic domain superfamily / Neutral zinc metallopeptidases, zinc-binding region signature. / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 2.8 Å DetailsAuthors Mosyak, L. / Stahl, M. / Somers, W. CitationJournal : Protein Sci. / Year : 2008Title : Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.Authors: Mosyak, L. / Georgiadis, K. / Shane, T. / Svenson, K. / Hebert, T. / McDonagh, T. / Mackie, S. / Olland, S. / Lin, L. / Zhong, X. / Kriz, R. / Reifenberg, E.L. / Collins-Racie, L.A. / ... Authors : Mosyak, L. / Georgiadis, K. / Shane, T. / Svenson, K. / Hebert, T. / McDonagh, T. / Mackie, S. / Olland, S. / Lin, L. / Zhong, X. / Kriz, R. / Reifenberg, E.L. / Collins-Racie, L.A. / Corcoran, C. / Freeman, B. / Zollner, R. / Marvell, T. / Vera, M. / Sum, P.E. / Lavallie, E.R. / Stahl, M. / Somers, W. History Deposition Oct 15, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 11, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Oct 20, 2021 Group : Database references / Derived calculationsCategory : database_2 / pdbx_struct_conn_angle ... database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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