[English] 日本語
![](img/lk-miru.gif)
- PDB-2g1n: Ketopiperazine-based renin inhibitors: Optimization of the "C" ring -
+
Open data
-
Basic information
Entry | Database: PDB / ID: 2g1n | ||||||
---|---|---|---|---|---|---|---|
Title | Ketopiperazine-based renin inhibitors: Optimization of the "C" ring | ||||||
![]() | Renin | ||||||
![]() | HYDROLASE / PROTEIN-LIGAND COMPLEXES | ||||||
Function / homology | ![]() renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process ...renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / angiotensin maturation / amyloid-beta metabolic process / Metabolism of Angiotensinogen to Angiotensins / cell maturation / response to cAMP / hormone-mediated signaling pathway / kidney development / insulin-like growth factor receptor binding / regulation of blood pressure / male gonad development / cellular response to xenobiotic stimulus / apical part of cell / peptidase activity / response to lipopolysaccharide / aspartic-type endopeptidase activity / signaling receptor binding / proteolysis / extracellular space / extracellular region / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Holsworth, D.D. | ||||||
![]() | ![]() Title: Ketopiperazine-based renin inhibitors: Optimization of the "C" ring Authors: Holsworth, D.D. / Cai, C. / Cheng, X.M. / Cody, W.L. / Downing, D.M. / Erasga, N. / Lee, C. / Powell, N.A. / Ednunds, J.J. / Stier, M. / Jalaie, M. / Zhang, E. / McConnell, P. / Ryan, M.J. / ...Authors: Holsworth, D.D. / Cai, C. / Cheng, X.M. / Cody, W.L. / Downing, D.M. / Erasga, N. / Lee, C. / Powell, N.A. / Ednunds, J.J. / Stier, M. / Jalaie, M. / Zhang, E. / McConnell, P. / Ryan, M.J. / Bryant, J. / Li, T. / Kasani, A. / Hall, E. / Subedi, R. / Rahim, M. / Maiti, S. | ||||||
History |
|
-
Structure visualization
Structure viewer | Molecule: ![]() ![]() |
---|
-
Downloads & links
-
Download
PDBx/mmCIF format | ![]() | 143.7 KB | Display | ![]() |
---|---|---|---|---|
PDB format | ![]() | 117 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 1 MB | Display | ![]() |
---|---|---|---|---|
Full document | ![]() | 1 MB | Display | |
Data in XML | ![]() | 34.2 KB | Display | |
Data in CIF | ![]() | 47.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2fs4C ![]() 2g1oC ![]() 2g1rC ![]() 2g1sC ![]() 2g1yC ![]() 2g20C ![]() 2g21C ![]() 2g22C ![]() 2g24C ![]() 2g26C ![]() 2g27C C: citing same article ( |
---|---|
Similar structure data |
-
Links
-
Assembly
Deposited unit | ![]()
| ||||||||
---|---|---|---|---|---|---|---|---|---|
1 | ![]()
| ||||||||
2 | ![]()
| ||||||||
Unit cell |
|
-
Components
#1: Protein | Mass: 36566.230 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #2: Sugar | #3: Chemical | #4: Water | ChemComp-HOH / | |
---|
-Experimental details
-Experiment
Experiment | Method: ![]() |
---|
-
Sample preparation
Crystal | Density Matthews: 3.26 Å3/Da / Density % sol: 62.22 % |
---|
-Data collection
Diffraction source | Source: ![]() ![]() ![]() |
---|---|
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Relative weight: 1 |
Reflection | Resolution: 2.9→50 Å / Num. obs: 20323 / % possible obs: 1 % |
Reflection shell | Highest resolution: 2.9 Å / % possible all: 0.999 |
-
Processing
Software | Name: CNS / Classification: refinement | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Method to determine structure: ![]()
| ||||||||||||||||
Displacement parameters | Biso mean: 38.1 Å2 | ||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.9→50 Å
|