Entry Database : PDB / ID : 2c0q Structure visualization Downloads & linksTitle non-aged form of mouse acetylcholinesterase inhibited by tabun ComponentsACETYLCHOLINESTERASE Details Keywords HYDROLASE / SERINE ESTERASE / ACETYLCHOLINESTERASEFunction / homology Function and homology informationFunction Domain/homology Component
acetylcholine metabolic process / serine hydrolase activity / choline binding / acetylcholine catabolic process / acetylcholine binding / acetylcholinesterase / acetylcholine receptor signaling pathway / choline metabolic process / positive regulation of dendrite morphogenesis / osteoblast development ... acetylcholine metabolic process / serine hydrolase activity / choline binding / acetylcholine catabolic process / acetylcholine binding / acetylcholinesterase / acetylcholine receptor signaling pathway / choline metabolic process / positive regulation of dendrite morphogenesis / osteoblast development / acetylcholinesterase activity / positive regulation of axonogenesis / basement membrane / regulation of receptor recycling / side of membrane / synaptic cleft / laminin binding / synapse assembly / collagen binding / response to insulin / neuromuscular junction / receptor internalization / nuclear envelope / retina development in camera-type eye / positive regulation of cold-induced thermogenesis / presynaptic membrane / postsynaptic membrane / cell adhesion / endoplasmic reticulum lumen / axon / neuronal cell body / synapse / dendrite / perinuclear region of cytoplasm / Golgi apparatus / cell surface / protein homodimerization activity / extracellular space / identical protein binding / plasma membrane Similarity search - Function Acetylcholinesterase, tetramerisation domain / Acetylcholinesterase tetramerisation domain / : / Cholinesterase / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase type B, active site / Carboxylesterases type-B serine active site. / Carboxylesterase, type B / Carboxylesterase family ... Acetylcholinesterase, tetramerisation domain / Acetylcholinesterase tetramerisation domain / : / Cholinesterase / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase type B, active site / Carboxylesterases type-B serine active site. / Carboxylesterase, type B / Carboxylesterase family / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species MUS MUSCULUS (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.5 Å DetailsAuthors Ekstrom, F. / Akfur, C. / Tunemalm, A.-K. / Lundberg, S. CitationJournal : Biochemistry / Year : 2006Title : Structural Changes of Phenylalanine 338 and Histidine 447 Revealed by the Crystal Structures of Tabun-Inhibited Murine Acetylcholinesterase.Authors : Ekstrom, F. / Akfur, C. / Tunemalm, A.-K. / Lundberg, S. History Deposition Sep 7, 2005 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 9, 2006 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Jan 17, 2018 Group : Data collection / Category : diffrn_source / Item : _diffrn_source.pdbx_synchrotron_siteRevision 1.4 May 12, 2021 Group : Derived calculations / OtherCategory : pdbx_database_status / pdbx_struct_assembly ... pdbx_database_status / pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / struct_conn Item : _pdbx_database_status.status_code_sf / _struct_conn.pdbx_leaving_atom_flagRevision 1.5 Dec 13, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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