Group: Atomic model / Data collection ...Atomic model / Data collection / Database references / Derived calculations / Non-polymer description / Other / Version format compliance
Revision 1.2
May 22, 2019
Group: Advisory / Data collection ...Advisory / Data collection / Other / Refinement description Category: pdbx_database_proc / pdbx_database_status ...pdbx_database_proc / pdbx_database_status / pdbx_unobs_or_zero_occ_atoms / refine Item: _pdbx_database_status.recvd_author_approval / _refine.pdbx_ls_cross_valid_method
Mass: 35898.340 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) HOMO SAPIENS (human) / Production host: ESCHERICHIA COLI (E. coli) / References: UniProt: P15121, aldose reductase
Mass: 18.015 Da / Num. of mol.: 613 / Source method: isolated from a natural source / Formula: H2O
Compound details
CATALYZES THE NADPH-DEPENDENT REDUCTION OF A WIDE RANGE OF CARBONYL-CONTAINING COMPOUNDS INTO ...CATALYZES THE NADPH-DEPENDENT REDUCTION OF A WIDE RANGE OF CARBONYL-CONTAINING COMPOUNDS INTO CORRESPONDING ALCOHOLS. THE PROTEIN IS THOUGHT TO PLAY A KEY ROLE IN DIABETIC COMPLICATIONS OF THREE OTHER TARGET TISSUES, NAMELY, NERVE, KIDNEY AND RETINA.
Sequence details
THE CONFLICT ANNOTATED IN THE SEQADV CARDS BELOW HAS HAS BEEN DESCRIBED IN J.BIOL.CHEM. 264:14775 ...THE CONFLICT ANNOTATED IN THE SEQADV CARDS BELOW HAS HAS BEEN DESCRIBED IN J.BIOL.CHEM. 264:14775 (1989). THE MEDLINE ID FOR THIS REFERENCE IS 89359274 AND THE PUBMED ID FOR THE SAME IS 2504709.
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 2
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Sample preparation
Crystal
Density Matthews: 2.16 Å3/Da / Density % sol: 43.01 %
Crystal grow
pH: 5 Details: AS DESCRIBED IN LAMOUR ET AL. (1999) ACTA CRYSTALL. SECTION D 55:721-723, pH 5.00
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