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Open data
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Basic information
Entry | Database: PDB / ID: 1qrd | ||||||
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Title | QUINONE REDUCTASE/FAD/CIBACRON BLUE/DUROQUINONE COMPLEX | ||||||
![]() | QUINONE-REDUCTASE | ||||||
![]() | QUINONE-REDUCTASE (CYTOSOLIC) / OXIDOREDUCTASE / FLAVOPROTEIN | ||||||
Function / homology | ![]() response to nitrogen compound / Regulation of ornithine decarboxylase (ODC) / response to L-glutamine / response to flavonoid / NAD(P)H dehydrogenase (quinone) / cellular response to metal ion / NADH oxidation / NADPH oxidation / : / response to tetrachloromethane ...response to nitrogen compound / Regulation of ornithine decarboxylase (ODC) / response to L-glutamine / response to flavonoid / NAD(P)H dehydrogenase (quinone) / cellular response to metal ion / NADH oxidation / NADPH oxidation / : / response to tetrachloromethane / response to xenobiotic stimulus => GO:0009410 / negative regulation of catalytic activity / NAD(P)H dehydrogenase (quinone) activity / response to hydrogen sulfide / response to alkaloid / response to carbohydrate / superoxide metabolic process / response to testosterone / response to amine / superoxide dismutase activity / response to electrical stimulus / response to nutrient / : / cell redox homeostasis / response to hormone / response to ischemia / response to organic cyclic compound / cellular response to hydrogen peroxide / positive regulation of neuron apoptotic process / response to estradiol / response to ethanol / response to oxidative stress / oxidoreductase activity / response to xenobiotic stimulus / neuronal cell body / dendrite / negative regulation of apoptotic process / identical protein binding / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() | ||||||
![]() | Li, R. / Bianchet, M.A. / Talalay, P. / Amzel, L.M. | ||||||
![]() | ![]() Title: The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction. Authors: Li, R. / Bianchet, M.A. / Talalay, P. / Amzel, L.M. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 125.5 KB | Display | ![]() |
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PDB format | ![]() | 97.9 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 723.1 KB | Display | ![]() |
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Full document | ![]() | 758.5 KB | Display | |
Data in XML | ![]() | 18.8 KB | Display | |
Data in CIF | ![]() | 24.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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2 | ![]()
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3 | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 30852.377 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) ![]() ![]() #2: Chemical | #3: Chemical | #4: Chemical | #5: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.76 Å3/Da / Density % sol: 55.36 % | ||||||||||||||||||||||||||||||
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Crystal grow | *PLUS pH: 7 / Method: vapor diffusion, hanging drop | ||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction source | Wavelength: 1.5418 |
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Detector | Type: SIEMENS |
Radiation | Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.5418 Å / Relative weight: 1 |
Reflection | Resolution: 2.3→30 Å / Num. obs: 23775 / % possible obs: 89.8 % / Observed criterion σ(I): 1 / Redundancy: 5 % |
Reflection | *PLUS Rmerge(I) obs: 0.05 |
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Processing
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Refinement | Resolution: 2.4→6 Å / σ(F): 2
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Refinement step | Cycle: LAST / Resolution: 2.4→6 Å
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Xplor file |
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Software | *PLUS Name: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints | *PLUS Type: x_improper_angle_d |