登録情報 | データベース: PDB / ID: 1eqg |
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タイトル | THE 2.6 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH IBUPROFEN |
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要素 | PROSTAGLANDIN H2 SYNTHASE-1 |
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キーワード | OXIDOREDUCTASE / EGF DOMAIN / NSAID Binding / Ibuprofen / Membrane-binding Domain / Cyclooxygenase / Peroxidase / Dioxygenase |
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機能・相同性 | 機能・相同性情報
prostaglandin-endoperoxide synthase / prostaglandin-endoperoxide synthase activity / oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen / cyclooxygenase pathway / prostaglandin biosynthetic process / regulation of blood pressure / peroxidase activity / response to oxidative stress / neuron projection / intracellular membrane-bounded organelle ...prostaglandin-endoperoxide synthase / prostaglandin-endoperoxide synthase activity / oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen / cyclooxygenase pathway / prostaglandin biosynthetic process / regulation of blood pressure / peroxidase activity / response to oxidative stress / neuron projection / intracellular membrane-bounded organelle / endoplasmic reticulum membrane / heme binding / protein homodimerization activity / metal ion binding / cytoplasm類似検索 - 分子機能 : / Myeloperoxidase, subunit C / Haem peroxidase domain superfamily, animal type / Haem peroxidase, animal-type / Haem peroxidase domain superfamily, animal type / Animal haem peroxidase / Animal heme peroxidase superfamily profile. / Laminin / Laminin / EGF-like domain ...: / Myeloperoxidase, subunit C / Haem peroxidase domain superfamily, animal type / Haem peroxidase, animal-type / Haem peroxidase domain superfamily, animal type / Animal haem peroxidase / Animal heme peroxidase superfamily profile. / Laminin / Laminin / EGF-like domain / Haem peroxidase superfamily / EGF-like domain profile. / EGF-like domain / Ribbon / Orthogonal Bundle / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 PROTOPORPHYRIN IX CONTAINING FE / IBUPROFEN / Prostaglandin G/H synthase 1類似検索 - 構成要素 |
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生物種 | Ovis aries (ヒツジ) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.61 Å |
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データ登録者 | Loll, P.J. / Selinsky, B.S. / Gupta, K. / Sharkey, C.T. |
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引用 | ジャーナル: Biochemistry / 年: 2001 タイトル: Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. 著者: Selinsky, B.S. / Gupta, K. / Sharkey, C.T. / Loll, P.J. |
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履歴 | 登録 | 2000年4月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2001年4月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月27日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 1.3 | 2018年1月31日 | Group: Advisory / Experimental preparation カテゴリ: exptl_crystal_grow / pdbx_unobs_or_zero_occ_atoms Item: _exptl_crystal_grow.pdbx_details / _pdbx_unobs_or_zero_occ_atoms.label_asym_id |
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改定 1.4 | 2018年2月28日 | Group: Experimental preparation / カテゴリ: exptl_crystal_grow / Item: _exptl_crystal_grow.temp |
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改定 1.5 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.mon_nstd_flag / _chem_comp.name ..._chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.6 | 2024年3月13日 | Group: Data collection / Database references ...Data collection / Database references / Source and taxonomy / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_src_syn Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.details |
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