EMDB-11278: Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRN...

Basic information

• Entry: Database: EMDB / ID: EMD-11278
• Title: Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide
• Map data: Combined map of five local-masked refined maps with sharpening and local-resolution filtering.

Sample

• Complex: Translating ribosome with insertase
  • Complex: Large subunit of ribosome
    • RNA: x 2 types
    • Protein or peptide: x 51 types
  • Complex: Small subunit of ribosome
    • RNA: x 1 types
    • Protein or peptide: x 30 types
  • Complex: OXA1L insertase
    • Protein or peptide: x 1 types
  • Protein or peptide: x 1 types
  • RNA: x 3 types
• Ligand: x 8 types

• Keywords: mitochondrion / translation / membrane insertion / translocon / peptidyl-tRNA / RIBOSOME

Function / homology

Function:

mitochondrial protein quality control / protein insertion into mitochondrial inner membrane from matrix / membrane insertase activity / negative regulation of oxidoreductase activity / Complex I biogenesis / mitochondrial ribosome binding / rRNA import into mitochondrion / mitochondrial transcription / mitochondrial translational termination / mitochondrial translational elongation / negative regulation of ATP-dependent activity / mitochondrial ribosome assembly / translation release factor activity, codon nonspecific / positive regulation of mitochondrial translation / microprocessor complex / Mitochondrial translation elongation / Mitochondrial translation termination / Mitochondrial translation initiation / mitochondrial proton-transporting ATP synthase complex assembly / mitochondrial large ribosomal subunit / negative regulation of mitotic nuclear division / Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters / peptidyl-tRNA hydrolase / mitochondrial ribosome / mitochondrial small ribosomal subunit / mitochondrial translation / aminoacyl-tRNA hydrolase activity / positive regulation of proteolysis / ribosomal small subunit binding / mitochondrial respiratory chain complex I assembly / anatomical structure morphogenesis / RNA processing / Mitochondrial protein degradation / aerobic respiration / rescue of stalled ribosome / apoptotic signaling pathway / cellular response to leukemia inhibitory factor / protein tetramerization / mitochondrial membrane / fibrillar center / double-stranded RNA binding / small ribosomal subunit rRNA binding / cell junction / regulation of translation / ribosomal small subunit assembly / small ribosomal subunit / 5S rRNA binding / large ribosomal subunit rRNA binding / nuclear membrane / endonuclease activity / cell population proliferation / tRNA binding / mitochondrial inner membrane / negative regulation of translation / nuclear body / rRNA binding / ribosome / structural constituent of ribosome / mitochondrial matrix / ribonucleoprotein complex / translation / protein domain specific binding / intracellular membrane-bounded organelle / mRNA binding / nucleotide binding / synapse / GTP binding / nucleolus / apoptotic process / positive regulation of DNA-templated transcription / protein homodimerization activity / protein-containing complex / mitochondrion / RNA binding / extracellular space / nucleoplasm / nucleus / plasma membrane / cytosol / cytoplasm

Domain/homology:

Membrane insertase YidC/Oxa1, C-terminal / 60Kd inner membrane protein / Membrane insertase YidC/ALB3/OXA1/COX18 / Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 / 28S ribosomal protein S26 / Mitochondrial ribosome subunit S26 / Cysteine alpha-hairpin motif superfamily / 28S ribosomal protein S27, mitochondrial / MRPS27/PTCD2 / Mitochondrial 28S ribosomal protein S27 / Ribosomal protein S22, mitochondrial / Ribosomal protein S23, mitochondrial / Ribosomal protein S23/S25, mitochondrial / Mitochondrial 28S ribosomal protein S31 / : / Mitochondrial 28S ribosomal protein S22 / Mitochondrial ribosomal protein S23 / Mitochondrial 28S ribosomal protein S31 / Ribosomal protein S29, mitochondrial / Ribosomal protein S28, mitochondrial / Mitochondrial 28S ribosomal protein S34 / 28S ribosomal protein S10, mitochondrial / Mitochondrial ribosomal protein MRP-S35 / Mitochondrial 28S ribosomal protein S34 / 28S ribosomal protein S24, mitochondrial / Pentatricopeptide repeat domain-containing protein 3 / 28S ribosomal protein S17, mitochondrial / 28S ribosomal protein S18b, mitochondrial / : / Mitochondrial ribosome subunit S24 / Small ribosomal subunit protein uS5m, N-terminal / Small ribosomal subunit protein mS39, PPR / 28S ribosomal protein S25, mitochondrial / : / : / Pentatricopeptide repeat domain / Ribosomal protein L55, mitochondrial / Mitochondrial ribosomal protein L48 / 39S ribosomal protein L40, mitochondrial / Mitochondrial ribosomal protein L55 superfamily / Mitochondrial ribosomal protein L55 / Ribosomal protein S27/S33, mitochondrial / Ribosomal protein S24/S35, mitochondrial / Mitochondrial ribosomal subunit S27 / Ribosomal protein L37, mitochondrial / Mitochondrial ribosomal protein L46 NUDIX / Mitochondrial ribosomal protein L37 / Ribosomal protein S24/S35, mitochondrial, conserved domain / Ribosomal protein S30, mitochondrial / Mitochondrial ribosomal subunit protein / Ribosomal protein L53, mitochondrial / 39S ribosomal protein L53/MRP-L53 / 39S ribosomal protein L42, mitochondrial / Mitochondrial 28S ribosomal protein S32 / Ribosomal protein L28/L40, mitochondrial / Mitochondrial ribosomal protein L28 / Ribosomal protein 63, mitochondrial / Growth arrest/ DNA-damage-inducible protein-interacting protein 1 / Ribosomal protein L51, mitochondrial / Growth arrest and DNA-damage-inducible proteins-interacting protein 1 / Mitochondrial ribosomal subunit / Mitochondrial ribosome protein 63 / Ribosomal protein L37/S30 / Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily / : / : / Mitochondrial 28S ribosomal protein S30 (PDCD9) / 39S ribosomal protein L52, mitochondrial / Mitoribosomal protein mL52 / : / Ribosomal protein L35, mitochondrial / MRPL44, double-stranded RNA binding domain / MRPL44 dsRNA-binding domain / Large ribosomal subunit protein mL44, endonuclease domain / : / Large ribosomal subunit protein bL9m C-terminal domain / Tim44-like domain / Tim44-like domain / Tim44 / Pentatricopeptide (PPR) repeat profile. / Ribosomal protein S23/S29, mitochondrial / Mitochondrial ribosomal death-associated protein 3 / : / Ribosomal protein L7/L12, oligomerisation / Ribosomal protein L7/L12, oligomerisation domain superfamily / Ribosomal protein L7/L12 dimerisation domain / : / Ribosomal protein L7/L12 / Ribosomal protein L7/L12, C-terminal / Ribosomal protein L7/L12 C-terminal domain / Pentatricopeptide repeat / Ribosomal protein L49/IMG2 / Mitochondrial mRNA-processing protein COX24, C-terminal / Mitochondrial large subunit ribosomal protein (Img2) / Mitochondrial mRNA-processing protein COX24, C-terminal / Mitochondrial domain of unknown function (DUF1713) / Ribosomal protein L46, N-terminal / 39S mitochondrial ribosomal protein L46 / Ribosomal protein L50, mitochondria / Ribosomal protein L27/L41, mitochondrial

Component:

Small ribosomal subunit protein uS12m / Small ribosomal subunit protein uS14m / Large ribosomal subunit protein bL33m / Large ribosomal subunit protein uL3m / Large ribosomal subunit protein bL19m / Small ribosomal subunit protein mS29 / Large ribosomal subunit protein bL12m / Small ribosomal subunit protein mS22 / Small ribosomal subunit protein mS25 / Small ribosomal subunit protein uS10m / Small ribosomal subunit protein mS35 / Small ribosomal subunit protein uS5m / Small ribosomal subunit protein uS11m / Small ribosomal subunit protein uS15m / Small ribosomal subunit protein bS21m / Small ribosomal subunit protein mS34 / Small ribosomal subunit protein bS6m / Small ribosomal subunit protein uS9m / Large ribosomal subunit protein bL28m / Large ribosomal subunit protein mL49 / Large ribosomal subunit protein mL62 / Mitochondrial inner membrane protein OXA1L / Large ribosomal subunit protein uL23m / Large ribosomal subunit protein mL51 / Large ribosomal subunit protein uL2m / Large ribosomal subunit protein mL54 / Large ribosomal subunit protein uL14m / Large ribosomal subunit protein bL21m / Large ribosomal subunit protein mL55 / Large ribosomal subunit protein uL10m / Large ribosomal subunit protein mL52 / Large ribosomal subunit protein mL41 / Large ribosomal subunit protein mL50 / Large ribosomal subunit protein mL43 / Large ribosomal subunit protein mL64 / Large ribosomal subunit protein uL30m / Small ribosomal subunit protein mS27 / Small ribosomal subunit protein mS31 / Large ribosomal subunit protein uL24m / Small ribosomal subunit protein mS37 / Large ribosomal subunit protein mL38 / Small ribosomal subunit protein uS3m / Large ribosomal subunit protein mL53 / Small ribosomal subunit protein mS39 / Large ribosomal subunit protein mL48 / Large ribosomal subunit protein bL34m / Large ribosomal subunit protein mL63 / Large ribosomal subunit protein mL45 / Large ribosomal subunit protein bL32m / Large ribosomal subunit protein bL20m / Large ribosomal subunit protein uL13m / Large ribosomal subunit protein bL9m / Large ribosomal subunit protein uL4m / Small ribosomal subunit protein mS26 / Large ribosomal subunit protein mL37 / Large ribosomal subunit protein uL18m / Large ribosomal subunit protein mL46 / Large ribosomal subunit protein mL44 / Large ribosomal subunit protein uL29m / Large ribosomal subunit protein mL65 / Large ribosomal subunit protein mL40 / Large ribosomal subunit protein bL17m / Large ribosomal subunit protein mL66 / Small ribosomal subunit protein mS38 / Large ribosomal subunit protein uL22m / Large ribosomal subunit protein uL16m / Large ribosomal subunit protein mL39 / Large ribosomal subunit protein bL35m / Large ribosomal subunit protein uL15m / Large ribosomal subunit protein bL36m / Large ribosomal subunit protein bL27m / Small ribosomal subunit protein mS33 / Small ribosomal subunit protein bS1m / Small ribosomal subunit protein uS17m / Small ribosomal subunit protein uS7m / Small ribosomal subunit protein uS2m / Large ribosomal subunit protein uL11m / Small ribosomal subunit protein bS16m / Small ribosomal subunit protein bS18m / Small ribosomal subunit protein mS23 / Small ribosomal subunit protein mS40 / Large ribosomal subunit protein mL42

• Biological species: Homo sapiens (human)
• Method: single particle reconstruction / cryo EM / Resolution: 2.89 Å
• Authors: Itoh Y / Andrell J

Funding support

Sweden, 1 items

Organization	Grant number	Country
European Research Council (ERC)		Sweden

• Citation: Journal: Science / Year: 2021; Title: Mechanism of membrane-tethered mitochondrial protein synthesis.; Authors: Yuzuru Itoh / Juni Andréll / Austin Choi / Uwe Richter / Priyanka Maiti / Robert B Best / Antoni Barrientos / Brendan J Battersby / Alexey Amunts / ; Abstract: Mitochondrial ribosomes (mitoribosomes) are tethered to the mitochondrial inner membrane to facilitate the cotranslational membrane insertion of the synthesized proteins. We report cryo-electron microscopy structures of human mitoribosomes with nascent polypeptide, bound to the insertase oxidase assembly 1-like (OXA1L) through three distinct contact sites. OXA1L binding is correlated with a series of conformational changes in the mitoribosomal large subunit that catalyze the delivery of newly synthesized polypeptides. The mechanism relies on the folding of mL45 inside the exit tunnel, forming two specific constriction sites that would limit helix formation of the nascent chain. A gap is formed between the exit and the membrane, making the newly synthesized proteins accessible. Our data elucidate the basis by which mitoribosomes interact with the OXA1L insertase to couple protein synthesis and membrane delivery.

History

Deposition	Jul 1, 2020	-
Header (metadata) release	Jan 13, 2021	-
Map release	Jan 13, 2021	-
Update	Nov 15, 2023	-
Current status	Nov 15, 2023	Processing site: PDBe / Status: Released

Map

• File: Download / File: emd_11278.map.gz / Format: CCP4 / Size: 600.7 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• Annotation: Combined map of five local-masked refined maps with sharpening and local-resolution filtering.
• Voxel size: X=Y=Z: 0.83 Å

Density

Contour Level	By AUTHOR: 3.0 / Movie #1: 3
Minimum - Maximum	-22.326777 - 42.749557000000003
Average (Standard dev.)	0.0042639575 (±1.0917519)

• Symmetry: Space group: 1

Details

EMDB XML:

Map geometry	Axis order Z Y X Origin 0 0 0 Dimensions 540 540 540 Spacing 540 540 540
Cell	A=B=C: 448.19998 Å α=β=γ: 90.0 °

CCP4 map header:

mode	Image stored as Reals
Å/pix. X/Y/Z	0.83	0.83	0.83
M x/y/z	540	540	540
origin x/y/z	0.000	0.000	0.000
length x/y/z	448.200	448.200	448.200
α/β/γ	90.000	90.000	90.000
start NX/NY/NZ	0	0	0
NX/NY/NZ	540	540	540
MAP C/R/S	3	2	1
start NC/NR/NS	0	0	0
NC/NR/NS	540	540	540
D min/max/mean	-22.327	42.750	0.004

Supplemental data

Mask #1

• File: emd_11278_msk_1.map

Additional map: Combined map of five local-masked refined maps without sharpening.

• File: emd_11278_additional_1.map
• Annotation: Combined map of five local-masked refined maps without sharpening.

Half map: Local-masked refined map using the mask covering the...

• File: emd_11278_half_map_1.map
• Annotation: Local-masked refined map using the mask covering the LSU-core and the insertase.

Half map: Local-masked refined map using the mask covering the...

• File: emd_11278_half_map_2.map
• Annotation: Local-masked refined map using the mask covering the LSU-core and the insertase.

Sample components

Entire : Translating ribosome with insertase

• Entire: Name: Translating ribosome with insertase

Components

• Complex: Translating ribosome with insertase
  • Complex: Large subunit of ribosome
    • RNA: 16S mitochondrial rRNA
    • RNA: mitochondrial tRNAVal
    • Protein or peptide: 39S ribosomal protein L2, mitochondrial
    • Protein or peptide: 39S ribosomal protein L3, mitochondrial
    • Protein or peptide: 39S ribosomal protein L4, mitochondrial
    • Protein or peptide: 39S ribosomal protein L9, mitochondrial
    • Protein or peptide: 39S ribosomal protein L10, mitochondrial
    • Protein or peptide: 39S ribosomal protein L11, mitochondrial
    • Protein or peptide: 39S ribosomal protein L13, mitochondrial
    • Protein or peptide: 39S ribosomal protein L14, mitochondrial
    • Protein or peptide: 39S ribosomal protein L15, mitochondrial
    • Protein or peptide: 39S ribosomal protein L16, mitochondrial
    • Protein or peptide: 39S ribosomal protein L17, mitochondrial
    • Protein or peptide: 39S ribosomal protein L18, mitochondrial
    • Protein or peptide: 39S ribosomal protein L19, mitochondrial
    • Protein or peptide: 39S ribosomal protein L20, mitochondrial
    • Protein or peptide: 39S ribosomal protein L21, mitochondrial
    • Protein or peptide: 39S ribosomal protein L22, mitochondrial
    • Protein or peptide: 39S ribosomal protein L23, mitochondrial
    • Protein or peptide: 39S ribosomal protein L24, mitochondrial
    • Protein or peptide: 39S ribosomal protein L27, mitochondrial
    • Protein or peptide: 39S ribosomal protein L28, mitochondrial
    • Protein or peptide: 39S ribosomal protein L47, mitochondrial
    • Protein or peptide: 39S ribosomal protein L30, mitochondrial
    • Protein or peptide: 39S ribosomal protein L32, mitochondrial
    • Protein or peptide: 39S ribosomal protein L33, mitochondrial
    • Protein or peptide: 39S ribosomal protein L34, mitochondrial
    • Protein or peptide: 39S ribosomal protein L35, mitochondrial
    • Protein or peptide: 39S ribosomal protein L36, mitochondrial
    • Protein or peptide: 39S ribosomal protein L37, mitochondrial
    • Protein or peptide: 39S ribosomal protein L38, mitochondrial
    • Protein or peptide: 39S ribosomal protein L39, mitochondrial
    • Protein or peptide: 39S ribosomal protein L40, mitochondrial
    • Protein or peptide: 39S ribosomal protein L41, mitochondrial
    • Protein or peptide: 39S ribosomal protein L42, mitochondrial
    • Protein or peptide: 39S ribosomal protein L43, mitochondrial
    • Protein or peptide: 39S ribosomal protein L44, mitochondrial
    • Protein or peptide: 39S ribosomal protein L45, mitochondrial
    • Protein or peptide: 39S ribosomal protein L46, mitochondrial
    • Protein or peptide: 39S ribosomal protein L48, mitochondrial
    • Protein or peptide: 39S ribosomal protein L49, mitochondrial
    • Protein or peptide: 39S ribosomal protein L50, mitochondrial
    • Protein or peptide: 39S ribosomal protein L51, mitochondrial
    • Protein or peptide: 39S ribosomal protein L52, mitochondrial
    • Protein or peptide: 39S ribosomal protein L53, mitochondrial
    • Protein or peptide: 39S ribosomal protein L54, mitochondrial
    • Protein or peptide: 39S ribosomal protein L55, mitochondrial
    • Protein or peptide: Ribosomal protein 63, mitochondrial
    • Protein or peptide: Peptidyl-tRNA hydrolase ICT1, mitochondrial
    • Protein or peptide: Growth arrest and DNA damage-inducible proteins-interacting protein 1
    • Protein or peptide: 39S ribosomal protein S18a, mitochondrial
    • Protein or peptide: 39S ribosomal protein S30, mitochondrial
    • Protein or peptide: 39S ribosomal protein L12, mitochondrial
  • Complex: Small subunit of ribosome
    • RNA: 12S mitochondrial rRNA
    • Protein or peptide: 28S ribosomal protein S2, mitochondrial
    • Protein or peptide: 28S ribosomal protein S24, mitochondrial
    • Protein or peptide: 28S ribosomal protein S5, mitochondrial
    • Protein or peptide: 28S ribosomal protein S6, mitochondrial
    • Protein or peptide: 28S ribosomal protein S7, mitochondrial
    • Protein or peptide: 28S ribosomal protein S9, mitochondrial
    • Protein or peptide: 28S ribosomal protein S10, mitochondrial
    • Protein or peptide: 28S ribosomal protein S11, mitochondrial
    • Protein or peptide: 28S ribosomal protein S12, mitochondrial
    • Protein or peptide: 28S ribosomal protein S14, mitochondrial
    • Protein or peptide: 28S ribosomal protein S15, mitochondrial
    • Protein or peptide: 28S ribosomal protein S16, mitochondrial
    • Protein or peptide: 28S ribosomal protein S17, mitochondrial
    • Protein or peptide: 28S ribosomal protein S18b, mitochondrial
    • Protein or peptide: 28S ribosomal protein S18c, mitochondrial
    • Protein or peptide: 28S ribosomal protein S21, mitochondrial
    • Protein or peptide: 28S ribosomal protein S22, mitochondrial
    • Protein or peptide: 28S ribosomal protein S23, mitochondrial
    • Protein or peptide: 28S ribosomal protein S25, mitochondrial
    • Protein or peptide: 28S ribosomal protein S26, mitochondrial
    • Protein or peptide: 28S ribosomal protein S27, mitochondrial
    • Protein or peptide: 28S ribosomal protein S28, mitochondrial
    • Protein or peptide: 28S ribosomal protein S29, mitochondrial
    • Protein or peptide: 28S ribosomal protein S31, mitochondrial
    • Protein or peptide: 28S ribosomal protein S33, mitochondrial
    • Protein or peptide: 28S ribosomal protein S34, mitochondrial
    • Protein or peptide: 28S ribosomal protein S35, mitochondrial
    • Protein or peptide: Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
    • Protein or peptide: Aurora kinase A-interacting protein
    • Protein or peptide: Pentatricopeptide repeat domain-containing protein 3, mitochondrial
  • Complex: OXA1L insertase
    • Protein or peptide: Mitochondrial inner membrane protein OXA1L
  • Protein or peptide: Nascent polypeptide
  • RNA: A-site tRNA with aminoacylation
  • RNA: P-site tRNA
  • RNA: mRNA
• Ligand: MAGNESIUM ION
• Ligand: POTASSIUM ION
• Ligand: ZINC ION
• Ligand: FE2/S2 (INORGANIC) CLUSTER
• Ligand: ADENOSINE-5'-TRIPHOSPHATE
• Ligand: GUANOSINE-5'-TRIPHOSPHATE
• Ligand: ALANINE
• Ligand: water

Supramolecule #1: Translating ribosome with insertase

• Supramolecule: Name: Translating ribosome with insertase / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#89; Details: Mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 2 MDa

Supramolecule #2: Large subunit of ribosome

• Supramolecule: Name: Large subunit of ribosome / type: complex / ID: 2 / Parent: 1 / Macromolecule list: #1-#53
• Source (natural): Organism: Homo sapiens (human)

Supramolecule #3: Small subunit of ribosome

• Supramolecule: Name: Small subunit of ribosome / type: complex / ID: 3 / Parent: 1 / Macromolecule list: #54-#84
• Source (natural): Organism: Homo sapiens (human)

Supramolecule #4: OXA1L insertase

• Supramolecule: Name: OXA1L insertase / type: complex / ID: 4 / Parent: 1 / Macromolecule list: #85
• Source (natural): Organism: Homo sapiens (human)

Macromolecule #1: 16S mitochondrial rRNA

• Macromolecule: Name: 16S mitochondrial rRNA / type: rna / ID: 1 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 500.671 KDa

Sequence

String:

GCUAAACCUA GCCCCAAACC CACUCCACCU UACUACCAGA CAACCUUAGC CAAACCAUUU ACCCAAAUAA AGUAUAGGCG AUAGAAAUU GAAACCUGGC GCAAUAGAUA UAGUACCGCA AGGGAAAGAU GAAAAAUUAU AACCAAGCAU AAUAUAGCAA G GACUAACC CCUAUACCUU CUGCAUAAUG AAUUAACUAG AAAUAACUUU GCAAGGAGAG CCAAAGCUAA GACCCCCGAA AC CAGACGA GCUACCUAAG AACAGCUAAA AGAGCACACC CGUCUAUGUA GCAAAAUAGU GGGAAGAUUU AUAGGUAGAG GCG ACAAAC CUACCGAGCC UGGUGAUAGC UGGUUGUCCA AGAUAGAAUC UUAGUUCAAC UUUAAAUUUG CCCACAGAAC CCUC UAAAU CCCCUUGUAA AUUUAACUGU UAGUCCAAAG AGGAACAGCU CUUUGGACAC UAGGAAAAAA CCUUGUAGAG AGAGU AAAA AAUUUAACAC CCAUAGUAGG CCUAAAAGCA GCCACCAAUU AAGAAAGCGU UCAAGCUCAA CACCCACUAC CUAAAA AAU CCCAAACAUA UAACUGAACU CCUCACACCC AAUUGGACCA AUCUAUCACC CUAUAGAAGA ACUAAUGUUA GUAUAAG UA ACAUGAAAAC AUUCUCCUCC GCAUAAGCCU GCGUCAGAUU AAAACACUGA ACUGACAAUU AACAGCCCAA UAUCUACA A UCAACCAACA AGUCAUUAUU ACCCUCACUG UCAACCCAAC ACAGGCAUGC UCAUAAGGAA AGGUUAAAAA AAGUAAAAG GAACUCGGCA AAUCUUACCC CGCCUGUUUA CCAAAAACAU CACCUCUAGC AUCACCAGUA UUAGAGGCAC CGCCUGCCCA GUGACACAU GUUUAACGGC CGCGGUACCC UAACCGUGCA AAGGUAGCAU AAUCACUUGU UCCUUAAAUA GGGACCUGUA U GAAUGGCU CCACGAGGGU UCAGCUGUCU CUUACUUUUA ACCAGUGAAA UUGACCUGCC CGUGAAGAGG CGGGCAUAAC AC AGCAAGA CGAGAAGACC CUAUGGAGCU UUAAUUUAUU AAUGCAAACA GUACCUAACA AACCCACAGG UCCUAAACUA CCA AACCUG CAUUAAAAAU UUCGGUUGGG GCGACCUCGG AGCAGAACCC AACCUCCGAG CAGUACAUGC UAAGACUUCA CCAG UCAAA GCGAACUACU AUACUCAAUU GAUCCAAUAA CUUGACCAAC GGAACAAGUU ACCCUAGGGA UAACAGCGCA AUCCU AUUC UAGAGUCCAU AUCAACAAUA GGGUUUACGA CCUCGAUGUU GGAUCAGGAC AUCCCGAUGG UGCAGCCGCU AUUAAA GGU UCGUUUGUUC AACGAUUAAA GUCCUACGUG AUCUGAGUUC AGACCGGAGU AAUCCAGGUC GGUUUCUAUC UACUUUC AA AUUCCUCCCU GUACGAAAGG ACAAGAGAAA UAAGGCCUAC UUCACAAAGC GCCUUCCCCC GUAAAUGAUA UCAUCUCA A CUUAGUAUUA UACCCACACC CACCCAAGAA CAGGGUUUGU

GENBANK: GENBANK: MK321331.1

Macromolecule #2: mitochondrial tRNAVal

• Macromolecule: Name: mitochondrial tRNAVal / type: rna / ID: 2 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.961699 KDa

Sequence

String:

CAGAGUGUAG CUUAACACAA AGCACCCAAC UUACACUUAG GAGAUUUCAA CUUAACUUGA CCGCUCUGAC CA

Macromolecule #54: 12S mitochondrial rRNA

• Macromolecule: Name: 12S mitochondrial rRNA / type: rna / ID: 54 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 306.120094 KDa

Sequence

String:

AUAGGUUUGG UCCUAGCCUU UCUAUUAGCU CUUAGUAAGA UUACACAUGC AAGCAUCCCC GUUCCAGUGA GUUCACCCUC UAAAUCACC ACGAUCAAAA GGGACAAGCA UCAAGCACGC AGCAAUGCAG CUCAAAACGC UUAGCCUAGC CACACCCCCA C GGGAAACA GCAGUGAUUA ACCUUUAGCA AUAAACGAAA GUUUAACUAA GCUAUACUAA CCCCAGGGUU GGUCAAUUUC GU GCCAGCC ACCGCGGUCA CACGAUUAAC CCAAGUCAAU AGAAGCCGGC GUAAAGAGUG UUUUAGAUCA CCCCCUCCCC AAU AAAGCU AAAACUCACC UGAGUUGUAA AAAACUCCAG UUGACACAAA AUAGACUACG AAAGUGGCUU UAACAUAUCU GAAC ACACA AUAGCUAAGA CCCAAACUGG GAUUAGAUAC CCCACUAUGC UUAGCCCUAA ACCUCAACAG UUAAAUCAAC AAAAC UGCU CGCCAGAACA CUACGAGCCA CAGCUUAAAA CUCAAAGGAC CUGGCGGUGC UUCAUAUCCC UCUAGAGGAG CCUGUU CUG UAAUCGAUAA ACCCCGAUCA ACCUCACCAC CUCUUGCUCA GCCUAUAUAC CGCCAUCUUC AGCAAACCCU GAUGAAG GC UACAAAGUAA GCGCAAGUAC CCACGUAAAG ACGUUAGGUC AAGGUGUAGC CCAUGAGGUG GCAAGAAAUG GGCUACAU U UUCUACCCCA GAAAACUACG AUAGCCCUUA UGAAACUUAA GGGUCGAAGG UGGAUUUAGC AGUAAACUGA GAGUAGAGU GCUUAGUUGA ACAGGGCCCU GAAGCGCGUA CACACCGCCC GUCACCCUCC UCAAGUAUAC UUCAAAGGAC AUUUAACUAA AACCCCUAC GCAUUUAUAU AGAGGAGACA AGUCGUAACA UGGUAAGUGU ACUGGAAAGU GCACUUGGAC GAACC

GENBANK: GENBANK: MN849737.1

Macromolecule #87: A-site tRNA with aminoacylation

• Macromolecule: Name: A-site tRNA with aminoacylation / type: rna / ID: 87 ; Details: Mixture of any mitochondrial tRNAs. Each residue was assigned as either A, U, G, or C, based on the density and conservation.; Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.682877 KDa

Sequence

String:

UGGUAUAUAG UUUAAACAAA ACGAAUGAUU UCGACUCAUU AAAUUAUGAU AAUCAUAUUU ACCAACCA

Macromolecule #88: P-site tRNA

• Macromolecule: Name: P-site tRNA / type: rna / ID: 88 ; Details: Mixture of any mitochondrial tRNAs. Each residue was assigned as either A, U, G, or C, based on the density and conservation.; Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.369307 KDa

Sequence

String:

UAGGGAAUAG UUUAAAAAAC AGCUGACUUU CAAUCAGCAG AUGGAGGUUC AAUUCCUCCU UCCCUAACCA

Macromolecule #89: mRNA

• Macromolecule: Name: mRNA / type: rna / ID: 89 ; Details: Mixture of any mitochondrial mRNAs. Each residue was assigned as either A, U, G, or C, based on the density and conservation.; Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 6.00353 KDa

Sequence

String:

UUUAAGAACG UGUUUAUUU

Macromolecule #3: 39S ribosomal protein L2, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L2, mitochondrial / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.355941 KDa

Sequence

String:

MALCALTRAL RSLNLAPPTV AAPAPSLFPA AQMMNNGLLQ QPSALMLLPC RPVLTSVALN ANFVSWKSRT KYTITPVKMR KSGGRDHTG RIRVHGIGGG HKQRYRMIDF LRFRPEETKS GPFEEKVIQV RYDPCRSADI ALVAGGSRKR WIIATENMQA G DTILNSNH IGRMAVAARE GDAHPLGALP VGTLINNVES EPGRGAQYIR AAGTCGVLLR KVNGTAIIQL PSKRQMQVLE TC VATVGRV SNVDHNKRVI GKAGRNRWLG KRPNSGRWHR KGGWAGRKIR PLPPMKSYVK LPSASAQS

UniProtKB: Large ribosomal subunit protein uL2m

Macromolecule #4: 39S ribosomal protein L3, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L3, mitochondrial / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 38.689562 KDa

Sequence

String:

MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHP WEPGSFRVGL IALKLGMMPL WTKDGQKHVV TLLQVQDCHV LKYTSKENCN GKMATLSVGG KTVSRFRKAT S ILEFYREL GLPPKQTVKI FNITDNAAIK PGTPLYAAHF RPGQYVDVTA KTIGKGFQGV MKRWGFKGQP ATHGQTKTHR RP GAVATGD IGRVWPGTKM PGKMGNIYRT EYGLKVWRIN TKHNIIYVNG SVPGHKNCLV KVKDSKLPAY KDLGKNLPFP TYF PDGDEE ELPEDLYDEN VCQPGAPSIT FA

UniProtKB: Large ribosomal subunit protein uL3m

Macromolecule #5: 39S ribosomal protein L4, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L4, mitochondrial / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 34.970195 KDa

Sequence

String:

MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK VELPVPTHRR PVQAWVESLR GFEQERVGLA DLHPDVFAT APRLDILHQV AMWQKNFKRI SYAKTKTRAE VRGGGRKPWP QKGTGRARHG SIRSPLWRGG GVAHGPRGPT S YYYMLPMK VRALGLKVAL TVKLAQDDLH IMDSLELPTG DPQYLTELAH YRRWGDSVLL VDLTHEEMPQ SIVEATSRLK TF NLIPAVG LNVHSMLKHQ TLVLTLPTVA FLEDKLLWQD SRYRPLYPFS LPYSDFPRPL PHATQGPAAT PYHC

UniProtKB: Large ribosomal subunit protein uL4m

Macromolecule #6: 39S ribosomal protein L9, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L9, mitochondrial / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 30.296355 KDa

Sequence

String:

MAAPVVTAPG RALLRAGAGR LLRGGVQELL RPRHEGNAPD LACNFSLSQN RGTVIVERWW KVPLAGEGRK PRLHRRHRVY KLVEDTKHR PKENLELILT QSVENVGVRG DLVSVKKSLG RNRLLPQGLA VYASPENKKL FEEEKLLRQE GKLEKIQTKA G EATVKFLK SCRLEVGMKN NVKWELNPEI VARHFFKNLG VVVAPHTLKL PEEPITRWGE YWCEVTVNGL DTVRVPMSVV NF EKPKTKR YKYWLAQQAA KAMAPTSPQI

UniProtKB: Large ribosomal subunit protein bL9m

Macromolecule #7: 39S ribosomal protein L10, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L10, mitochondrial / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 29.322529 KDa

Sequence

String:

MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV TEYIPPKPAI HPSCLPSPPS PPQEEIGLIR LLRREIAAV FQDNRMIAVC QNVALSAEDK LLMRHQLRKH KILMKVFPNQ VLKPFLEDSK YQNLLPLFVG HNMLLVSEEP K VKEMVRIL RTVPFLPLLG GCIDDTILSR QGFINYSKLP SLPLVQGELV GGLTCLTAQT HSLLQHQPLQ LTTLLDQYIR EQ REKDSVM SANGKPDPDT VPDS

UniProtKB: Large ribosomal subunit protein uL10m

Macromolecule #8: 39S ribosomal protein L11, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L11, mitochondrial / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.716227 KDa

Sequence

String:

MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC KEFNERTKDI KEGIPLPTKI LVKPDRTFEI KIGQPTVSY FLKAAAGIEK GARQTGKEVA GLVTLKHVYE IARIKAQDEA FALQDVPLSS VVRSIIGSAR SLGIRVVKDL S SEELAAFQ KERAIFLAAQ KEADLAAQEE AAKK

UniProtKB: Large ribosomal subunit protein uL11m

Macromolecule #9: 39S ribosomal protein L13, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L13, mitochondrial / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.633824 KDa

Sequence

String:

(SAC)SFSRAPQQW ATFARIWYLL DGKMQPPGKL AAMASIRLQG LHKPVYHALS DCGDHVVIMN TRHIAFSGNK WEQKVY SSH TGYPGGFRQV TAAQLHLRDP VAIVKLAIYG MLPKNLHRRT MMERLHLFPD EYIPEDILKN LVEELPQPRK IPKRLDE YT QEEIDAFPRL WTPPEDYRL

UniProtKB: Large ribosomal subunit protein uL13m

Macromolecule #10: 39S ribosomal protein L14, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L14, mitochondrial / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.973702 KDa

Sequence

String:

MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP YHRAPRCIHV YKKNGVGKVG DQILLAIKGQ KKKALIVGH CMPGPRMTPR FDSNNVVLIE DNGNPVGTRI KTPIPTSLRK REGEYSKVLA IAQNFV

UniProtKB: Large ribosomal subunit protein uL14m

Macromolecule #11: 39S ribosomal protein L15, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L15, mitochondrial / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.47382 KDa

Sequence

String:

MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG RGHKGERQRG TRPRLGFEGG QTPFYIRIPK YGFNEGHSF RRQYKPLSLN RLQYLIDLGR VDPSQPIDLT QLVNGRGVTI QPLKRDYGVQ LVEEGADTFT AKVNIEVQLA S ELAIAAIE KNGGVVTTAF YDPRSLDIVC KPVPFFLRGQ PIPKRMLPPE ELVPYYTDAK NRGYLADPAK FPEARLELAR KY GYILPDI TKDELFKMLC TRKDPRQIFF GLAPGWVVNM ADKKILKPTD ENLLKYYTS

UniProtKB: Large ribosomal subunit protein uL15m

Macromolecule #12: 39S ribosomal protein L16, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L16, mitochondrial / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 28.496285 KDa

Sequence

String:

MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAI LALGGGYLHW GHFEMMRLTI NRSMDPKNMF AIWRVPAPFK PITRKSVGHR MGGGKGAIDH YVTPVKAGRL V VEMGGRCE FEEVQGFLDQ VAHKLPFAAK AVSRGTLEKM RKDQEERERN NQNPWTFERI ATANMLGIRK VLSPYDLTHK GK YWGKFYM PKRV

UniProtKB: Large ribosomal subunit protein uL16m

Macromolecule #13: 39S ribosomal protein L17, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L17, mitochondrial / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.083266 KDa

Sequence

String:

MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD EMRGYAEKLI DYGKLGDTNE RAMRMADFWL TEKDLIPKL FQVLAPRYKD QTGGYTRMLQ IPNRSLDRAK MAVIEYKGNC LPPLPLPRRD SHLTLLNQLL QGLRQDLRQS Q EASNHSSH TAQTPGI

UniProtKB: Large ribosomal subunit protein bL17m

Macromolecule #14: 39S ribosomal protein L18, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L18, mitochondrial / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.60757 KDa

Sequence

String:

MALRSRFWGL FSVCRNPGCR FAALSTSSEP AAKPEVDPVE NEAVAPEFTN RNPRNLELLS VARKERGWRT VFPSREFWHR LRVIRTQHH VEALVEHQNG KVVVSASTRE WAIKKHLYST RNVVACESIG RVLAQRCLEA GINFMVYQPT PWEAASDSMK R LQSAMTEG GVVLREPQRI YE

UniProtKB: Large ribosomal subunit protein uL18m

Macromolecule #15: 39S ribosomal protein L19, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L19, mitochondrial / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.584996 KDa

Sequence

String:

MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE PGAFQPPPKP VIVDKHRPVE PERRFLSPEF IPRRGRTDP LKFQIERKDM LERRKVLHIP EFYVGSILRV TTADPYASGK ISQFLGICIQ RSGRGLGATF ILRNVIEGQG V EICFELYN PRVQEIQVVK LEKRLDDSLL YLRDALPEYS TFDVNMKPVV QEPNQKVPVN ELKVKMKPKP WSKRWERPNF NI KGIRFDL CLTEQQMKEA QKWNQPWLEF DMMREYDTSK IEAAIWKEIE ASKRS

UniProtKB: Large ribosomal subunit protein bL19m

Macromolecule #16: 39S ribosomal protein L20, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L20, mitochondrial / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 17.479654 KDa

Sequence

String:

MVFLTAQLWL RNRVTDRYFR IQEVLKHARH FRGRKNRCYR LAVRTVIRAF VKCTKARYLK KKNMRTLWIN RITAASQEHG LKYPALIGN LVKCQVELNR KVLADLAIYE PKTFKSLAAL ASRRRHEGFA AALGDGKEPE GIFSRVVQYH

UniProtKB: Large ribosomal subunit protein bL20m

Macromolecule #17: 39S ribosomal protein L21, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L21, mitochondrial / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.847682 KDa

Sequence

String:

MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY VPKTSLSSPP WPEVVLPDPV EETRHHAEVV KKVNEMIVT GQYGRLFAVV HFASRQWKVT SEDLILIGNE LDLACGERIR LEKVLLVGAD NFTLLGKPLL GKDLVRVEAT V IEKTESWP RIIMRFRKRK NFKKKRIVTT PQTVLRINSI EIAPCLL

UniProtKB: Large ribosomal subunit protein bL21m

Macromolecule #18: 39S ribosomal protein L22, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L22, mitochondrial / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 23.683732 KDa

Sequence

String:

MAAAVLGQLG ALWIHNLRSR GKLALGVLPQ SYIHTSASLD ISRKWEKKNK IVYPPQLPGE PRRPAEIYHC RRQIKYSKDK MWYLAKLIR GMSIDQALAQ LEFNDKKGAK IIKEVLLEAQ DMAVRDHNVE FRSNLYIAES TSGRGQCLKR IRYHGRGRFG I MEKVYCHY FVKLVEGPPP PPEPPKTAVA HAKEYIQQLR SRTIVHTL

UniProtKB: Large ribosomal subunit protein uL22m

Macromolecule #19: 39S ribosomal protein L23, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L23, mitochondrial / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 17.718029 KDa

Sequence

String:

(AYA)RNVVYPLYR LGGPQLRVFR TNFFIQLVRP GVAQPEDTVQ FRIPMEMTRV DLRNYLEGIY NVPVAAVRTR VQHGSN KRR DHRNVRIKKP DYKVAYVQLA HGQTFTFPDL FPEKDESPEG SAADDLYSML EEERQQRQSS DPRRGGVPSW FGL

UniProtKB: Large ribosomal subunit protein uL23m

Macromolecule #20: 39S ribosomal protein L24, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L24, mitochondrial / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.953875 KDa

Sequence

String:

MRLSALLALA SKVTLPPHYR YGMSPPGSVA DKRKNPPWIR RRPVVVEPIS DEDWYLFCGD TVEILEGKDA GKQGKVVQVI RQRNWVVVG GLNTHYRYIG KTMDYRGTMI PSEAPLLHRQ VKLVDPMDRK PTEIEWRFTE AGERVRVSTR SGRIIPKPEF P RADGIVPE TWIDGPKDTS VEDALERTYV PCLKTLQEEV MEAMGIKETR KYKKVYWY

UniProtKB: Large ribosomal subunit protein uL24m

Macromolecule #21: 39S ribosomal protein L27, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L27, mitochondrial / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 16.102859 KDa

Sequence

String:

MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR QGIKKMEGHY VHAGNIIATQ RHFRWHPGAH VGVGKNKCL YALEEGIVRY TKEVYVPHPR NTEAVDLITR LPKGAVLYKT FVHVVPAKPE GTFKLVAML

UniProtKB: Large ribosomal subunit protein bL27m

Macromolecule #22: 39S ribosomal protein L28, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L28, mitochondrial / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 30.202867 KDa

Sequence

String:

MPLHKYPVWL WKRLQLREGI CSRLPGHYLR SLEEERTPTP VHYRPHGAKF KINPKNGQRE RVEDVPIPIY FPPESQRGLW GGEGWILGQ IYANNDKLSK RLKKVWKPQL FEREFYSEIL DKKFTVTVTM RTLDLIDEAY GLDFYILKTP KEDLCSKFGM D LKRGMLLR LARQDPQLHP EDPERRAAIY DKYKEFAIPE EEAEWVGLTL EEAIEKQRLL EEKDPVPLFK IYVAELIQQL QQ QALSEPA VVQKRASGQ

UniProtKB: Large ribosomal subunit protein bL28m

Macromolecule #23: 39S ribosomal protein L47, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L47, mitochondrial / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 29.508535 KDa

Sequence

String:

MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGFFLSLLP KSTPNVTSFH QYRLLHTTLS RKGLEEFFDD PKNWGQEKVK SGAAWTCQQ LRNKSNEDLH KLWYVLLKER NMLLTLEQEA KRQRLPMPSP ERLDKVVDSM DALDKVVQER EDALRLLQTG Q ERARPGAW RRDIFGRIIW HKFKQWVIPW HLNKRYNRKR FFALPYVDHF LRLEREKRAR IKARKENLER KKAKILLKKF PH LAEAQKS SLV

UniProtKB: Large ribosomal subunit protein uL29m

Macromolecule #24: 39S ribosomal protein L30, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L30, mitochondrial / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 18.582812 KDa

Sequence

String:

MAGILRLVVQ WPPGRLQTVT KGVESLICTD WIRHKFTRSR IPEKVFQASP EDHEKYGGDP QNPHKLHIVT RIKSTRRRPY WEKDIIKML GLEKAHTPQV HKNIPSVNAK LKVVKHLIRI KPLKLPQGLP AEENMSNTCL KSTGELVVQW HLKPVEQKAH E S

UniProtKB: Large ribosomal subunit protein uL30m

Macromolecule #25: 39S ribosomal protein L32, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L32, mitochondrial / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.437799 KDa

Sequence

String:

MALAMLVLVV SPWSAARGVL RNYWERLLRK LPQSRPGFPS PPWGPALAVQ GPAMFTEPAN DTSGSKENSS LLDSIFWMAA PKNRRTIEV NRCRRRNPQK LIKVKNNIDV CPECGHLKQK HVLCAYCYEK VCKETAEIRR QIGKQEGGPF KAPTIETVVL Y TGETPSEQ DQGKRIIERD RKRPSWFTQN

UniProtKB: Large ribosomal subunit protein bL32m

Macromolecule #26: 39S ribosomal protein L33, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L33, mitochondrial / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 7.635204 KDa

Sequence

String:

MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV KQRVLFVEKK KIRSL

UniProtKB: Large ribosomal subunit protein bL33m

Macromolecule #27: 39S ribosomal protein L34, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L34, mitochondrial / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 10.183913 KDa

Sequence

String:

MAVLAGSLLG PTSRSAALLG GRWLQPRAWL GFPDAWGLPT PQQARGKARG NEYQPSNIKR KNKHGWVRRL STPAGVQVIL RRMLKGRKS LSH

UniProtKB: Large ribosomal subunit protein bL34m

Macromolecule #28: 39S ribosomal protein L35, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L35, mitochondrial / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.558488 KDa

Sequence

String:

MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKL PVRSLTYFSA RKGKRKTVKA VIDRFLRLHC GLWVRRKAGY KKKLWKKTPA RKKRLREFVF CNKTQSKLLD K MTTSFWKR RNWYVDDPYQ KYHDRTNLKV

UniProtKB: Large ribosomal subunit protein bL35m

Macromolecule #29: 39S ribosomal protein L36, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L36, mitochondrial / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 11.809301 KDa

Sequence

String:

MANLFIRKMV NPLLYLSRHT VKPRALSTFL FGSIRGAAPV AVEPGAAVRS LLSPGLLPHL LPALGFKNKT VLKKRCKDCY LVKRRGRWY VYCKTHPRHK QRQM

UniProtKB: Large ribosomal subunit protein bL36m

Macromolecule #30: 39S ribosomal protein L37, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L37, mitochondrial / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 48.183344 KDa

Sequence

String:

MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY EIPGLEPITF AGKMHFVPWL ARPIFPPWDR GYKDPRFYR SPPLHEHPLY KDQACYIFHH RCRLLEGVKQ ALWLTKTKLI EGLPEKVLSL VDDPRNHIEN QDECVLNVIS H ARLWQTTE EIPKRETYCP VIVDNLIQLC KSQILKHPSL ARRICVQNST FSATWNRESL LLQVRGSGGA RLSTKDPLPT IA SREEIEA TKNHVLETFY PISPIIDLHE CNIYDVKNDT GFQEGYPYPY PHTLYLLDKA NLRPHRLQPD QLRAKMILFA FGS ALAQAR LLYGNDAKVL EQPVVVQSVG TDGRVFHFLV FQLNTTDLDC NEGVKNLAWV DSDQLLYQHF WCLPVIKKRV VVEP VGPVG FKPETFRKFL ALYLHGAA

UniProtKB: Large ribosomal subunit protein mL37

Macromolecule #31: 39S ribosomal protein L38, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L38, mitochondrial / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 44.65943 KDa

Sequence

String:

MAAPWWRAAL CECRRWRGFS TSAVLGRRTP PLGPMPNSDI DLSNLERLEK YRSFDRYRRR AEQEAQAPHW WRTYREYFGE KTDPKEKID IGLPPPKVSR TQQLLERKQA IQELRANVEE ERAARLRTAS VPLDAVRAEW ERTCGPYHKQ RLAEYYGLYR D LFHGATFV PRVPLHVAYA VGEDDLMPVY CGNEVTPTEA AQAPEVTYEA EEGSLWTLLL TSLDGHLLEP DAEYLHWLLT NI PGNRVAE GQVTCPYLPP FPARGSGIHR LAFLLFKQDQ PIDFSEDARP SPCYQLAQRT FRTFDFYKKH QETMTPAGLS FFQ CRWDDS VTYIFHQLLD MREPVFEFVR PPPYHPKQKR FPHRQPLRYL DRYRDSHEPT YGIY

UniProtKB: Large ribosomal subunit protein mL38

Macromolecule #32: 39S ribosomal protein L39, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L39, mitochondrial / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 38.764785 KDa

Sequence

String:

MEALAMGSRA LRLWLVAPGG GIKWRFIATS SASQLSPTEL TEMRNDLFNK EKARQLSLTP RTEKIEVKHV GKTDPGTVFV MNKNISTPY SCAMHLSEWY CRKSILALVD GQPWDMYKPL TKSCEIKFLT FKDCDPGEVN KAYWRSCAMM MGCVIERAFK D EYMVNLVR APEVPVISGA FCYDVVLDSK LDEWMPTKEN LRSFTKDAHA LIYKDLPFET LEVEAKVALE IFQHSKYKVD FI EEKASQN PERIVKLHRI GDFIDVSEGP LIPRTSICFQ YEVSAVHNLQ PTQPSLIRRF QGVSLPVHLR AHFTIWDKLL ERS RKMVTE DQSKATEECT ST

UniProtKB: Large ribosomal subunit protein mL39

Macromolecule #33: 39S ribosomal protein L40, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L40, mitochondrial / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.534422 KDa

Sequence

String:

MTASVLRSIS LALRPTSGLL GTWQTQLRET HQRASLLSFW ELIPMRSEPL RKKKKVDPKK DQEAKERLKR KIRKLEKATQ ELIPIEDFI TPLKFLDKAR ERPQVELTFE ETERRALLLK KWSLYKQQER KMERDTIRAM LEAQQEALEE LQLESPKLHA E AIKRDPNL FPFEKEGPHY TPPIPNYQPP EGRYNDITKV YTQVEFKR

UniProtKB: Large ribosomal subunit protein mL40

Macromolecule #34: 39S ribosomal protein L41, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L41, mitochondrial / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.404708 KDa

Sequence

String:

MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAA QLFSEAVAPA IEKDFKDGTF DPDNLEKYGF EPTQEGKLFQ LYPRNFLR

UniProtKB: Large ribosomal subunit protein mL41

Macromolecule #35: 39S ribosomal protein L42, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L42, mitochondrial / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 16.691176 KDa

Sequence

String:

MAVAAVKWVM SKRTILKHLF PVQNGALYCV CHKSTYSPLP DDYNCNVELA LTSDGRTIVC YHPSVDIPYE HTKPIPRPDP VHNNEETHD QVLKTRLEEK VEHLEEGPMI EQLSKMFFTT KHRWYPHGRY HRCRKNLNPP KDR

UniProtKB: Large ribosomal subunit protein mL42

Macromolecule #36: 39S ribosomal protein L43, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L43, mitochondrial / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 23.368631 KDa

Sequence

String:

(THC)ARGTPSRFL ASVLHNGLGR YVQQLQRLSF SVSRDGASSR GAREFVEREV IDFARRNPGV VIYVNSRPCC VPRVVA EYL NGAVREESIH CKSVEEISTL VQKLADQSGL DVIRIRKPFH TDNPSIQGQW HPFTNKPTTF RGLRPREVQD PAPAQDT GL RLSAVAPQIL LPGWPDPPDL PTVDPISSSL TSAPAPMLSA VSCLPIVPAL TTVCSA

UniProtKB: Large ribosomal subunit protein mL43

Macromolecule #37: 39S ribosomal protein L44, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L44, mitochondrial / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO; EC number: Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 37.583312 KDa

Sequence

String:

MASGLVRLLQ QGHRCLLAPV APKLVPPVRG VKKGFRAAFR FQKELERQRL LRCPPPPVRR SEKPNWDYHA EIQAFGHRLQ ENFSLDLLK TAFVNSCYIK SEEAKRQQLG IEKEAVLLNL KSNQELSEQG TSFSQTCLTQ FLEDEYPDMP TEGIKNLVDF L TGEEVVCH VARNLAVEQL TLSEEFPVPP AVLQQTFFAV IGALLQSSGP ERTALFIRDF LITQMTGKEL FEMWKIINPM GL LVEELKK RNVSAPESRL TRQSGGTTAL PLYFVGLYCD KKLIAEGPGE TVLVAEEEAA RVALRKLYGF TENRRPWNYS KPK ETLRAE KSITAS

UniProtKB: Large ribosomal subunit protein mL44

Macromolecule #38: 39S ribosomal protein L45, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L45, mitochondrial / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 35.402918 KDa

Sequence

String:

MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF KTEKEFMQHA RKAGLVIPPE KSDRSIHLAC TAGIFDAYV PPEGDARISS LSKEGLIERT ERMKKTMASQ VSIRRIKDYD ANFKIKDFPE KAKDIFIEAH LCLNNSDHDR L HTLVTEHC FPDMTWDIKY KTVRWSFVES LEPSHVVQVR CSSMMNQGNV YGQITVRMHT RQTLAIYDRF GRLMYGQEDV PK DVLEYVV FEKQLTNPYG SWRMHTKIVP PWAPPKQPIL KTVMIPGPQL KPEEEYEEAQ GEAQKPQLA

UniProtKB: Large ribosomal subunit protein mL45

Macromolecule #39: 39S ribosomal protein L46, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L46, mitochondrial / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 31.748107 KDa

Sequence

String:

MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA LCLQRPPVVS KPLTPLQEEM ASLLQQIEIE RSLYSDHEL RALDENQRLA KKKADLHDEE DEQDILLAQD LEDMWEQKFL QFKLGARITE ADEKNDRTSL NRKLDRNLVL L VREKFGDQ DVWILPQAEW QPGETLRGTA ERTLATLSEN NMEAKFLGNA PCGHYTFKFP QAMRTESNLG AKVFFFKALL LT GDFSQAG NKGHHVWVTK DELGDYLKPK YLAQVRRFVS DL

UniProtKB: Large ribosomal subunit protein mL46

Macromolecule #40: 39S ribosomal protein L48, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L48, mitochondrial / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 23.970814 KDa

Sequence

String:

MSGTLEKVLC LRNNTIFKQA FSLLRFRTSG EKPIYSVGGI LLSISRPYKT KPTHGIGKYK HLIKAEEPKK KKGKVEVRAI NLGTDYEYG VLNIHLTAYD MTLAESYAQY VHNLCNSLSI KVEESYAMPT KTIEVLQLQD QGSKMLLDSV LTTHERVVQI S GLSATFAE IFLEIIQSSL PEGVRLSVKE HTEEDFKGRF KARPELEELL AKLK

UniProtKB: Large ribosomal subunit protein mL48

Macromolecule #41: 39S ribosomal protein L49, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L49, mitochondrial / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 19.225043 KDa

Sequence

String:

MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRS RMHNIPVYKD ITHGNRQMTV IRKVEGDIWA LQKDVEDFLS PLLGKTPVTQ VNEVTGTLRI KGYFDQELKA W LLEKGF

UniProtKB: Large ribosomal subunit protein mL49

Macromolecule #42: 39S ribosomal protein L50, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L50, mitochondrial / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 18.349943 KDa

Sequence

String:

MAARSVSGIT RRVFMWTVSG TPCREFWSRF RKEKEPVVVE TVEEKKEPIL VCPPLRSRAY TPPEDLQSRL ESYVKEVFGS SLPSNWQDI SLEDSRLKFN LLAHLADDLG HVVPNSRLHQ MCRVRDVLDF YNVPIQDRSK FDELSASNLP PNLKITWSY

UniProtKB: Large ribosomal subunit protein mL50

Macromolecule #43: 39S ribosomal protein L51, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L51, mitochondrial / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.125917 KDa

Sequence

String:

MAGNLLSGAG RRLWDWVPLA CRSFSLGVPR LIGIRLTLPP PKVVDRWNEK RAMFGVYDNI GILGNFEKHP KELIRGPIWL RGWKGNELQ RCIRKRKMVG SRMFADDLHN LNKRIRYLYK HFNRHGKFR

UniProtKB: Large ribosomal subunit protein mL51

Macromolecule #44: 39S ribosomal protein L52, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L52, mitochondrial / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 13.682658 KDa

Sequence

String:

MAALGTVLFT GVRRLHCSVA AWAGGQWRLQ QGLAANPSGY GPLTELPDWS YADGRPAPPM KGQLRRKAER ETFARRVVLL SQEMDAGLQ AWQLRQQKLQ EEQRKQENAL KPKGASLKSP LPSQ

UniProtKB: Large ribosomal subunit protein mL52

Macromolecule #45: 39S ribosomal protein L53, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L53, mitochondrial / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 12.036701 KDa

Sequence

String:

(AYA)AALARLGLR PVKQVRVQFC PFEKNVESTR TFLQTVSSEK VRSTNLNCSV IADVRHDGSE PCVDVLFGDG HRLIMR GAH LTALEMLTAF ASHIRARDAA GSGDKPGADT GR

UniProtKB: Large ribosomal subunit protein mL53

Macromolecule #46: 39S ribosomal protein L54, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L54, mitochondrial / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.844178 KDa

Sequence

String:

MATKRLFGAT RTWAGWGAWE LLNPATSGRL LARDYAKKPV MKGAKSGKGA VTSEALKDPD VCTDPVQLTT YAMGVNIYKE GQDVPLKPD AEYPEWLFEM NLGPPKTLEE LDPESREYWR RLRKQNIWRH NRLSKNKRL

UniProtKB: Large ribosomal subunit protein mL54

Macromolecule #47: 39S ribosomal protein L55, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L55, mitochondrial / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.160433 KDa

Sequence

String:

MAAVGSLLGR LRQSTVKATG PALRRLHTSS WRADSSRASL TRVHRQAYAR LYPVLLVKQD GSTIHIRYRE PRRMLAMPID LDTLSPEER RARLRKREAQ LQSRKEYEQE LSDDLHVERY RQFWTRTKK

UniProtKB: Large ribosomal subunit protein mL55

Macromolecule #48: Ribosomal protein 63, mitochondrial

• Macromolecule: Name: Ribosomal protein 63, mitochondrial / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 12.292333 KDa

Sequence

String:

MFLTALLWRG RIPGRQWIGK HRRPRFVSLR AKQNMIRRLE IEAENHYWLS MPYMTREQER GHAAVRRREA FEAIKAAATS KFPPHRFIA DQLDHLNVTK KWS

UniProtKB: Large ribosomal subunit protein mL63

Macromolecule #49: Peptidyl-tRNA hydrolase ICT1, mitochondrial

• Macromolecule: Name: Peptidyl-tRNA hydrolase ICT1, mitochondrial / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidyl-tRNA hydrolase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 23.674203 KDa

Sequence

String:

MAATRCLRWG LSRAGVWLLP PPARCPRRAL HKQKDGTEFK SIYSLDKLYP ESQGSDTAWR VPNGAKQADS DIPLDRLTIS YCRSSGPGG QNVNKVNSKA EVRFHLATAE WIAEPVRQKI AITHKNKINR LGELILTSES SRYQFRNLAD CLQKIRDMIT E ASQTPKEP TKEDVKLHRI RIENMNRERL RQKRIHSAVK TSRRVDMD

UniProtKB: Large ribosomal subunit protein mL62

Macromolecule #50: Growth arrest and DNA damage-inducible proteins-interacting protein 1

• Macromolecule: Name: Growth arrest and DNA damage-inducible proteins-interacting protein 1; type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 25.426895 KDa

Sequence

String:

MAASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW QLGPRYAAKQ FARYGAASGV VPGSLWPSPE QLRELEAEE REWYPSLATM QESLRVKQLA EEQKRREREQ HIAECMAKMP QMIVNWQQQQ RENWEKAQAD KERRARLQAE A QELLGYQV DPRSARFQEL LQDLEKKERK RLKEEKQKRK KEARAAALAA AVAQDPAASG APSS

UniProtKB: Large ribosomal subunit protein mL64

Macromolecule #51: 39S ribosomal protein S18a, mitochondrial

• Macromolecule: Name: 39S ribosomal protein S18a, mitochondrial / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.224078 KDa

Sequence

String:

MAALKALVSG CGRLLRGLLA GPAATSWSRL PARGFREVVE TQEGKTTIIE GRITATPKES PNPPNPSGQC PICRWNLKHK YNYDDVLLL SQFIRPHGGM LPRKITGLCQ EEHRKIEECV KMAHRAGLLP NHRPRLPEGV VPKSKPQLNR YLTRWAPGSV K PIYKKGPR WNRVRMPVGS PLLRDNVCYS RTPWKLYH

UniProtKB: Large ribosomal subunit protein mL66

Macromolecule #52: 39S ribosomal protein S30, mitochondrial

• Macromolecule: Name: 39S ribosomal protein S30, mitochondrial / type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 50.429578 KDa

Sequence

String:

MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS MTADSKAARL RRIERWQATV HAAESVDEKL RILTKMQFM KYMVYPQTFA LNADRWYQYF TKTVFLSGLP PPPAEPEPEP EPEPEPALDL AALRAVACDC LLQEHFYLRR R RRVHRYEE SEVISLPFLD QLVSTLVGLL SPHNPALAAA ALDYRCPVHF YWVRGEEIIP RGHRRGRIDD LRYQIDDKPN NQ IRISKQL AEFVPLDYSV PIEIPTIKCK PDKLPLFKRQ YENHIFVGSK TADPCCYGHT QFHLLPDKLR RERLLRQNCA DQI EVVFRA NAIASLFAWT GAQAMYQGFW SEADVTRPFV SQAVITDGKY FSFFCYQLNT LALTTQADQN NPRKNICWGT QSKP LYETI EDNDVKGFND DVLLQIVHFL LNRPKEEKSQ LLEN

UniProtKB: Large ribosomal subunit protein mL65

Macromolecule #53: 39S ribosomal protein L12, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L12, mitochondrial / type: protein_or_peptide / ID: 53 / Number of copies: 6 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.378164 KDa

Sequence

String:

MLPAAARPLW GPCLGLRAAA FRLARRQVPC VCAVRHMRSS GHQRCEALAG APLDNAPKEY PPKIQQLVQD IASLTLLEIS DLNELLKKT LKIQDVGLVP MGGVMSGAVP AAAAQEAVEE DIPIAKERTH FTVRLTEAKP VDKVKLIKEI KNYIQGINLV Q AKKLVESL PQEIKANVAK AEAEKIKAAL EAVGGTVVLE

UniProtKB: Large ribosomal subunit protein bL12m

Macromolecule #55: 28S ribosomal protein S2, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S2, mitochondrial / type: protein_or_peptide / ID: 55 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.298238 KDa

Sequence

String:

MATSSAALPR ILGAGARAPS RWLGFLGKAT PRPARPSRRT LGSATALMIR ESEDSTDFND KILNEPLKHS DFFNVKELFS VRSLFDARV HLGHKAGCRH RFMEPYIFGS RLDHDIIDLE QTATHLQLAL NFTAHMAYRK GIILFISRNR QFSYLIENMA R DCGEYAHT RYFRGGMLTN ARLLFGPTVR LPDLIIFLHT LNNIFEPHVA VRDAAKMNIP TVGIVDTNCN PCLITYPVPG ND DSPLAVH LYCRLFQTAI TRAKEKRQQV EALYRLQGQK EPGDQGPAHP PGADMSHSL

UniProtKB: Small ribosomal subunit protein uS2m

Macromolecule #56: 28S ribosomal protein S24, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S24, mitochondrial / type: protein_or_peptide / ID: 56 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 19.046164 KDa

Sequence

String:

MAASVCSGLL GPRVLSWSRE LPCAWRALHT SPVCAKNRAA RVRVSKGDKP VTYEEAHAPH YIAHRKGWLS LHTGNLDGED HAAERTVED VFLRKFMWGT FPGCLADQLV LKRRGNQLEI CAVVLRQLSP HKYYFLVGYS ETLLSYFYKC PVRLHLQTVP S KVVYKYL

UniProtKB: Small ribosomal subunit protein uS3m

Macromolecule #57: 28S ribosomal protein S5, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S5, mitochondrial / type: protein_or_peptide / ID: 57 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 48.094594 KDa

Sequence

String:

MATAVRAVGC LPVLCSGTAG HLLGRQCSLN TLPAASILAW KSVLGNGHLS SLGTRDTHPY ASLSRALQTQ CCISSPSHLM SQQYRPYSF FTKLTADELW KGALAETGAG AKKGRGKRTK KKKRKDLNRG QIIGEGRYGF LWPGLNVPLM KNGAVQTIAQ R SKEEQEKV EADMIQQREE WDRKKKMKVK RERGWSGNSW GGISLGPPDP GPCGETYEDF DTRILEVRNV FTMTAKEGRK KS IRVLVAV GNGKGAAGFS IGKATDRMDA FRKAKNRAVH HLHYIERYED HTIFHDISLR FKRTHIKMKK QPKGYGLRCH RAI ITICRL IGIKDMYAKV SGSINMLSLT QGLFRGLSRQ ETHQQLADKK GLHVVEIREE CGPLPIVVAS PRGPLRKDPE PEDE VPDVK LDWEDVKTAQ GMKRSVWSNL KRAAT

UniProtKB: Small ribosomal subunit protein uS5m

Macromolecule #58: 28S ribosomal protein S6, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S6, mitochondrial / type: protein_or_peptide / ID: 58 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 14.250588 KDa

Sequence

String:

MPRYELALIL KAMQRPETAA TLKRTIEALM DRGAIVRDLE NLGERALPYR ISAHSQQHNR GGYFLVDFYA PTAAVESMVE HLSRDIDVI RGNIVKHPLT QELKECEGIV PVPLAEKLYS TKKRKK

UniProtKB: Small ribosomal subunit protein bS6m

Macromolecule #59: 28S ribosomal protein S7, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S7, mitochondrial / type: protein_or_peptide / ID: 59 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 28.186154 KDa

Sequence

String:

MAAPAVKVAR GWSGLALGVR RAVLQLPGLT QVRWSRYSPE FKDPLIDKEY YRKPVEELTE EEKYVRELKK TQLIKAAPAG KTSSVFEDP VISKFTNMMM IGGNKVLARS LMIQTLEAVK RKQFEKYHAA SAEEQATIER NPYTIFHQAL KNCEPMIGLV P ILKGGRFY QVPVPLPDRR RRFLAMKWMI TECRDKKHQR TLMPEKLSHK LLEAFHNQGP VIKRKHDLHK MAEANRALAH YR WW

UniProtKB: Small ribosomal subunit protein uS7m

Macromolecule #60: 28S ribosomal protein S9, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S9, mitochondrial / type: protein_or_peptide / ID: 60 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 45.909859 KDa

Sequence

String:

MAAPCVSYGG AVSYRLLLWG RGSLARKQGL WKTAAPELQT NVRSQILRLR HTAFVIPKKN VPTSKRETYT EDFIKKQIEE FNIGKRHLA NMMGEDPETF TQEDIDRAIA YLFPSGLFEK RARPVMKHPE QIFPRQRAIQ WGEDGRPFHY LFYTGKQSYY S LMHDVYGM LLNLEKHQSH LQAKSLLPEK TVTRDVIGSR WLIKEELEEM LVEKLSDLDY MQFIRLLEKL LTSQCGAAEE EF VQRFRRS VTLESKKQLI EPVQYDEQGM AFSKSEGKRK TAKAEAIVYK HGSGRIKVNG IDYQLYFPIT QDREQLMFPF HFV DRLGKH DVTCTVSGGG RSAQAGAIRL AMAKALCSFV TEDEVEWMRQ AGLLTTDPRV RERKKPGQEG ARRKFTWKKR

UniProtKB: Small ribosomal subunit protein uS9m

Macromolecule #61: 28S ribosomal protein S10, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S10, mitochondrial / type: protein_or_peptide / ID: 61 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 23.0335 KDa

Sequence

String:

MAARTAFGAV CRRLWQGLGN FSVNTSKGNT AKNGGLLLST NMKWVQFSNL HVDVPKDLTK PVVTISDEPD ILYKRLSVLV KGHDKAVLD SYEYFAVLAA KELGISIKVH EPPRKIERFT LLQSVHIYKK HRVQYEMRTL YRCLELEHLT GSTADVYLEY I QRNLPEGV AMEVTKTQLE QLPEHIKEPI WETLSEEKEE SKS

UniProtKB: Small ribosomal subunit protein uS10m

Macromolecule #62: 28S ribosomal protein S11, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S11, mitochondrial / type: protein_or_peptide / ID: 62 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.649779 KDa

Sequence

String:

MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE QNAAPSHTKF SIYPPIPGEE SSLRWAGKKF EEIPIAHIK ASHNNTQIQV VSASNEPLAF ASCGTEGFRN AKKGTGIAAQ TAGIAAAARA KQKGVIHIRV VVKGLGPGRL S AMHGLIMG GLEVISITDN TPIPH(IAS)GCRP RKARKL

UniProtKB: Small ribosomal subunit protein uS11m

Macromolecule #63: 28S ribosomal protein S12, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S12, mitochondrial / type: protein_or_peptide / ID: 63 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.200947 KDa

Sequence

String:

MSWSGLLHGL NTSLTCGPAL VPRLWATCSM ATLNQMHRLG PPKRPPRKLG PTEGRPQLKG VVLCTFTRKP KKPNSANRKC CRVRLSTGR EAVCFIPGEG HTLQEHQIVL VEGGRTQDLP GVKLTVVRGK YDCGHVQKK

UniProtKB: Small ribosomal subunit protein uS12m

Macromolecule #64: 28S ribosomal protein S14, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S14, mitochondrial / type: protein_or_peptide / ID: 64 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.168788 KDa

Sequence

String:

MAAFMLGSLL RTFKQMVPSS ASGQVRSHYV DWRMWRDVKR RKMAYEYADE RLRINSLRKN TILPKILQDV ADEEIAALPR DSCPVRIRN RCVMTSRPRG VKRRWRLSRI VFRHLADHGQ LSGIQRATW

UniProtKB: Small ribosomal subunit protein uS14m

Macromolecule #65: 28S ribosomal protein S15, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S15, mitochondrial / type: protein_or_peptide / ID: 65 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 29.903293 KDa

Sequence

String:

MLRVAWRTLS LIRTRAVTQV LVPGLPGGGS AKFPFNQWGL QPRSLLLQAA RGYVVRKPAQ SRLDDDPPPS TLLKDYQNVP GIEKVDDVV KRLLSLEMAN KKEMLKIKQE QFMKKIVANP EDTRSLEARI IALSVKIRSY EEHLEKHRKD KAHKRYLLMS I DQRKKMLK NLRNTNYDVF EKICWGLGIE YTFPPLYYRR AHRRFVTKKA LCIRVFQETQ KLKKRRRALK AAAAAQKQAK RR NPDSPAK AIPKTLKDSQ

UniProtKB: Small ribosomal subunit protein uS15m

Macromolecule #66: 28S ribosomal protein S16, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S16, mitochondrial / type: protein_or_peptide / ID: 66 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.371899 KDa

Sequence

String:

MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ LGSYDPLPNS HGEKLVALNL DRIRHWIGCG AHLSKPMEK LLGLAGFFPL HPMMITNAER LRRKRAREVL LASQKTDAEA TDTEATET

UniProtKB: Small ribosomal subunit protein bS16m

Macromolecule #67: 28S ribosomal protein S17, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S17, mitochondrial / type: protein_or_peptide / ID: 67 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 14.526078 KDa

Sequence

String:

MSVVRSSVHA RWIVGKVIGT KMQKTAKVRV TRLVLDPYLL KYFNKRKTYF AHDALQQCTV GDIVLLRALP VPRAKHVKHE LAEIVFKVG KVIDPVTGKP CAGTTYLESP LSSETTQLSK NLEELNISSA Q

UniProtKB: Small ribosomal subunit protein uS17m

Macromolecule #68: 28S ribosomal protein S18b, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S18b, mitochondrial / type: protein_or_peptide / ID: 68 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 29.440629 KDa

Sequence

String:

MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP YKDEPWKYLE SEEYQERYGS RPVWADYRRN HKGGVPPQR TRKTCIRRNK VVGNPCPICR DHKLHVDFRN VKLLEQFVCA HTGIIFYAPY TGVCVKQHKR LTQAIQKARD H GLLIYHIP QVEPRDLDFS TSHGAVSATP PAPTLVSGDP WYPWYNWKQP PERELSRLRR LYQGHLQEES GPPPESMPKM PP RTPAEAS STGQTGPQSA L

UniProtKB: Small ribosomal subunit protein mS40

Macromolecule #69: 28S ribosomal protein S18c, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S18c, mitochondrial / type: protein_or_peptide / ID: 69 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.876786 KDa

Sequence

String:

MAAVVAVCGG LGRKKLTHLV TAAVSLTHPG THTVLWRRGC SQQVSSNEDL PISMENPYKE PLKKCILCGK HVDYKNVQLL SQFVSPFTG CIYGRHITGL CGKKQKEITK AIKRAQIMGF MPVTYKDPAY LKDPKVCNIR YRE

UniProtKB: Small ribosomal subunit protein bS18m

Macromolecule #70: 28S ribosomal protein S21, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S21, mitochondrial / type: protein_or_peptide / ID: 70 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 10.675494 KDa

Sequence

String:

(AYA)KHLKFIART VMVQEGNVES AYRTLNRILT MDGLIEDIKH RRYYEKPCRR RQRESYERCR RIYNMEMARK INFLMR KNR ADPWQGC

UniProtKB: Small ribosomal subunit protein bS21m

Macromolecule #71: 28S ribosomal protein S22, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S22, mitochondrial / type: protein_or_peptide / ID: 71 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 41.337316 KDa

Sequence

String:

MAPLGTTVLL WSLLRSSPGV ERVCFRARIQ PWHGGLLQPL PCSFEMGLPR RRFSSEAAES GSPETKKPTF MDEEVQSILT KMTGLNLQK TFKPAIQELK PPTYKLMTQA QLEEATRQAV EAAKVRLKMP PVLEERVPIN DVLAEDKILE GTETTKYVFT D ISYSIPHR ERFIVVREPS GTLRKASWEE RDRMIQVYFP KEGRKILTPI IFKEENLRTM YSQDRHVDVL NLCFAQFEPD ST EYIKVHH KTYEDIDKRG KYDLLRSTRY FGGMVWYFVN NKKIDGLLID QIQRDLIDDA TNLVQLYHVL HPDGQSAQGA KDQ AAEGIN LIKVFAKTEA QKGAYIELTL QTYQEALSRH SAAS

UniProtKB: Small ribosomal subunit protein mS22

Macromolecule #72: 28S ribosomal protein S23, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S23, mitochondrial / type: protein_or_peptide / ID: 72 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.805664 KDa

Sequence

String:

MAGSRLETVG SIFSRTRDLV RAGVLKEKPL WFDVYDAFPP LREPVFQRPR VRYGKAKAPI QDIWYHEDRI RAKFYSVYGS GQRAFDLFN PNFKSTCQRF VEKYTELQKL GETDEEKLFV ETGKALLAEG VILRRVGEAR TQHGGSHVSR KSEHLSVRPQ T ALEENETQ KEVPQDQHLE APADQSKGLL PP

UniProtKB: Small ribosomal subunit protein mS23

Macromolecule #73: 28S ribosomal protein S25, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S25, mitochondrial / type: protein_or_peptide / ID: 73 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.146428 KDa

Sequence

String:

MPMKGRFPIR RTLQYLSQGN VVFKDSVKVM TVNYNTHGEL GEGARKFVFF NIPQIQYKNP WVQIMMFKNM TPSPFLRFYL DSGEQVLVD VETKSNKEIM EHIRKILGKN EETLREEEEE KKQLSHPANF GPRKYCLREC ICEVEGQVPC PSLVPLPKEM R GKYKAALK ADAQD

UniProtKB: Small ribosomal subunit protein mS25

Macromolecule #74: 28S ribosomal protein S26, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S26, mitochondrial / type: protein_or_peptide / ID: 74 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.25982 KDa

Sequence

String:

MLRALSRLGA GTPCRPRAPL VLPARGRKTR HDPLAKSKIE RVNMPPAVDP AEFFVLMERY QHYRQTVRAL RMEFVSEVQR KVHEARAGV LAERKALKDA AEHRELMAWN QAENRRLHEL RIARLRQEER EQEQRQALEQ ARKAEEVQAW AQRKEREVLQ L QEEVKNFI TRENLEARVE AALDSRKNYN WAITREGLVV RPQRRDS

UniProtKB: Small ribosomal subunit protein mS26

Macromolecule #75: 28S ribosomal protein S27, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S27, mitochondrial / type: protein_or_peptide / ID: 75 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 47.669262 KDa

Sequence

String:

MAASIVRRGM LLARQVVLPQ LSPAGKRYLL SSAYVDSHKW EAREKEHYCL ADLASLMDKT FERKLPVSSL TISRLIDNIS SREEIDHAE YYLYKFRHSP NCWYLRNWTI HTWIRQCLKY DAQDKALYTL VNKVQYGIFP DNFTFNLLMD SFIKKENYKD A LSVVFEVM MQEAFEVPST QLLSLYVLFH CLAKKTDFSW EEERNFGASL LLPGLKQKNS VGFSSQLYGY ALLGKVELQQ GL RAVYHNM PLIWKPGYLD RALQVMEKVA ASPEDIKLCR EALDVLGAVL KALTSADGAS EEQSQNDEDN QGSEKLVEQL DIE ETEQSK LPQYLERFKA LHSKLQALGK IESEGLLSLT TQLVKEKLST CEAEDIATYE QNLQQWHLDL VQLIQREQQQ REQA KQEYQ AQKAAKASA

UniProtKB: Small ribosomal subunit protein mS27

Macromolecule #76: 28S ribosomal protein S28, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S28, mitochondrial / type: protein_or_peptide / ID: 76 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.878846 KDa

Sequence

String:

MAALCRTRAV AAESHFLRVF LFFRPFRGVG TESGSESGSS NAKEPKTRAG GFASALERHS ELLQKVEPLQ KGSPKNVESF ASMLRHSPL TQMGPAKDKL VIGRIFHIVE NDLYIDFGGK FHCVCRRPEV DGEKYQKGTR VRLRLLDLEL TSRFLGATTD T TVLEANAV LLGIQESKDS RSKEEHHEK

UniProtKB: Small ribosomal subunit protein bS1m

Macromolecule #77: 28S ribosomal protein S29, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S29, mitochondrial / type: protein_or_peptide / ID: 77 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 45.634406 KDa

Sequence

String:

MMLKGITRLI SRIHKLDPGR FLHMGTQARQ SIAAHLDNQV PVESPRAISR TNENDPAKHG DQHEGQHYNI SPQDLETVFP HGLPPRFVM QVKTFSEACL MVRKPALELL HYLKNTSFAY PAIRYLLYGE KGTGKTLSLC HVIHFCAKQD WLILHIPDAH L WVKNCRDL LQSSYNKQRF DQPLEASTWL KNFKTTNERF LNQIKVQEKY VWNKRESTEK GSPLGEVVEQ GITRVRNATD AV GIVLKEL KRQSSLGMFH LLVAVDGINA LWGRTTLKRE DKSPIAPEEL ALVHNLRKMM KNDWHGGAIV SALSQTGSLF KPR KAYLPQ ELLGKEGFDA LDPFIPILVS NYNPKEFESC IQYYLENNWL QHEKAPTEEG KKELLFLSNA NPSLLERHCA YL

UniProtKB: Small ribosomal subunit protein mS29

Macromolecule #78: 28S ribosomal protein S31, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S31, mitochondrial / type: protein_or_peptide / ID: 78 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 45.391473 KDa

Sequence

String:

MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA RTKNNIQRYF GTNSVICSKK DKQSVRTEET SKETSESQD SEKENTKKDL LGIIKGMKVE LSTVNVRTTK PPKRRPLKSL EATLGRLRRA TEYAPKKRIE PLSPELVAAA S AVADSLPF DKQTTKSELL SQLQQHEEES RAQRDAKRPK ISFSNIISDM KVARSATARV RSRPELRIQF DEGYDNYPGQ EK TDDLKKR KNIFTGKRLN IFDMMAVTKE APETDTSPSL WDVEFAKQLA TVNEQPLQNG FEELIQWTKE GKLWEFPINN EAG FDDDGS EFHEHIFLEK HLESFPKQGP IRHFMELVTC GLSKNPYLSV KQKVEHIEWF RNYFNEKKDI LKESNIQFN

UniProtKB: Small ribosomal subunit protein mS31

Macromolecule #79: 28S ribosomal protein S33, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S33, mitochondrial / type: protein_or_peptide / ID: 79 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 12.657776 KDa

Sequence

String:

MSSLSEYAFR MSRLSARLFG EVTRPTNSKS MKVVKLFSEL PLAKKKETYD WYPNHHTYAE LMQTLRFLGL YRDEHQDFMD EQKRLKKLR GKEKPKKGEG KRAAKRK

UniProtKB: Small ribosomal subunit protein mS33

Macromolecule #80: 28S ribosomal protein S34, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S34, mitochondrial / type: protein_or_peptide / ID: 80 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 25.695549 KDa

Sequence

String:

MARKKVRPRL IAELARRVRA LREQLNRPRD SQLYAVDYET LTRPFSGRRL PVRAWADVRR ESRLLQLLGR LPLFGLGRLV TRKSWLWQH DEPCYWRLTR VRPDYTAQNL DHGKAWGILT FKGKTESEAR EIEHVMYHDW RLVPKHEEEA FTAFTPAPED S LASVPYPP LLRAMIIAER QKNGDTSTEE PMLNVQRIRM EPWDYPAKQE DKGRAKGTPV

UniProtKB: Small ribosomal subunit protein mS34

Macromolecule #81: 28S ribosomal protein S35, mitochondrial

• Macromolecule: Name: 28S ribosomal protein S35, mitochondrial / type: protein_or_peptide / ID: 81 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 36.898328 KDa

Sequence

String:

MAAAALPAWL SLQSRARTLR AFSTAVYSAT PVPTPSLPER TPGNERPPRR KALPPRTEKM AVDQDWPSVY PVAAPFKPSA VPLPVRMGY PVKKGVPMAK EGNLELLKIP NFLHLTPVAI KKHCEALKDF CTEWPAALDS DEKCEKHFPI EIDSTDYVSS G PSVRNPRA RVVVLRVKLS SLNLDDHAKK KLIKLVGERY CKTTDVLTIK TDRCPLRRQN YDYAVYLLTV LYHESWNTEE WE KSKTEAD MEEYIWENSS SERNILETLL QMKAAEKNME INKEELLGTK EIEEYKKSVV SLKNEEENEN SISQYKESVK RLL NVT

UniProtKB: Small ribosomal subunit protein mS35

Macromolecule #82: Coiled-coil-helix-coiled-coil-helix domain-containing protein 1

• Macromolecule: Name: Coiled-coil-helix-coiled-coil-helix domain-containing protein 1; type: protein_or_peptide / ID: 82 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 13.409661 KDa

Sequence

String:

(AYA)TPSLRGRLA RFGNPRKPVL KPNKPLILAN RVGERRREKG EATCITEMSV MMACWKQNEF RDDACRKEIQ GFLDCA ARA QEARKMRSIQ ETLGESGSLL PNKLNKLLQR FPNKPYLS

UniProtKB: Small ribosomal subunit protein mS37

Macromolecule #83: Aurora kinase A-interacting protein

• Macromolecule: Name: Aurora kinase A-interacting protein / type: protein_or_peptide / ID: 83 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.395326 KDa

Sequence

String:

MLLGRLTSQL LRAVPWAGGR PPWPVSGVLG SRVCGPLYST SPAGPGRAAS LPRKGAQLEL EEMLVPRKMS VSPLESWLTA RCFLPRLDT GTAGTVAPPQ SYQCPPSQIG EGAEQGDEGV ADAPQIQCKN VLKIRRRKMN HHKYRKLVKK TRFLRRKVQE G RLRRKQIK FEKDLRRIWL KAGLKEAPEG WQTPKIYLRG K

UniProtKB: Small ribosomal subunit protein mS38

Macromolecule #84: Pentatricopeptide repeat domain-containing protein 3, mitochondrial

• Macromolecule: Name: Pentatricopeptide repeat domain-containing protein 3, mitochondrial; type: protein_or_peptide / ID: 84 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 78.648547 KDa

Sequence

String:

MAVVSAVRWL GLRSRLGQPL TGRRAGLCEQ ARSCRFYSGS ATLSKVEGTD VTGIEEVVIP KKKTWDKVAV LQALASTVNR DTTAVPYVF QDDPYLMPAS SLESRSFLLA KKSGENVAKF IINSYPKYFQ KDIAEPHIPC LMPEYFEPQI KDISEAALKE R IELRKVKA SVDMFDQLLQ AGTTVSLETT NSLLDLLCYY GDQEPSTDYH FQQTGQSEAL EEENDETSRR KAGHQFGVTW RA KNNAERI FSLMPEKNEH SYCTMIRGMV KHRAYEQALN LYTELLNNRL HADVYTFNAL IEATVCAINE KFEEKWSKIL ELL RHMVAQ KVKPNLQTFN TILKCLRRFH VFARSPALQV LREMKAIGIE PSLATYHHII RLFDQPGDPL KRSSFIIYDI MNEL MGKRF SPKDPDDDKF FQSAMSICSS LRDLELAYQV HGLLKTGDNW KFIGPDQHRN FYYSKFFDLI CLMEQIDVTL KWYED LIPS AYFPHSQTMI HLLQALDVAN RLEVIPKIWK DSKEYGHTFR SDLREEILML MARDKHPPEL QVAFADCAAD IKSAYE SQP IRQTAQDWPA TSLNCIAILF LRAGRTQEAW KMLGLFRKHN KIPRSELLNE LMDSAKVSNS PSQAIEVVEL ASAFSLP IC EGLTQRVMSD FAINQEQKEA LSNLTALTSD SDTDSSSDSD SDTSEGK

UniProtKB: Small ribosomal subunit protein mS39

Macromolecule #85: Mitochondrial inner membrane protein OXA1L

• Macromolecule: Name: Mitochondrial inner membrane protein OXA1L / type: protein_or_peptide / ID: 85 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 48.602688 KDa

Sequence

String:

MAMGLMCGRR ELLRLLQSGR RVHSVAGPSQ WLGKPLTTRL LFPVAPCCCR PHYLFLAASG PRSLSTSAIS FAEVQVQAPP VVAATPSPT AVPEVASGET ADVVQTAAEQ SFAELGLGSY TPVGLIQNLL EFMHVDLGLP WWGAIAACTV FARCLIFPLI V TGQREAAR IHNHLPEIQK FSSRIREAKL AGDHIEYYKA SSEMALYQKK HGIKLYKPLI LPVTQAPIFI SFFIALREMA NL PVPSLQT GGLWWFQDLT VSDPIYILPL AVTATMWAVL ELGAETGVQS SDLQWMRNVI RMMPLITLPI TMHFPTAVFM YWL SSNLFS LVQVSCLRIP AVRTVLKIPQ RVVHDLDKLP PREGFLESFK KGWKNAEMTR QLREREQRMR NQLELAARGP LRQT FTHNP LLQPGKDNPP NIPSSSSKPK SKYPWHDTLG

UniProtKB: Mitochondrial inner membrane protein OXA1L

Macromolecule #86: Nascent polypeptide

• Macromolecule: Name: Nascent polypeptide / type: protein_or_peptide / ID: 86 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 2.292505 KDa

Sequence

String:

AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AA

Macromolecule #90: MAGNESIUM ION

• Macromolecule: Name: MAGNESIUM ION / type: ligand / ID: 90 / Number of copies: 189 / Formula: MG
• Molecular weight: Theoretical: 24.305 Da

Macromolecule #91: POTASSIUM ION

• Macromolecule: Name: POTASSIUM ION / type: ligand / ID: 91 / Number of copies: 44 / Formula: K
• Molecular weight: Theoretical: 39.098 Da

Macromolecule #92: ZINC ION

• Macromolecule: Name: ZINC ION / type: ligand / ID: 92 / Number of copies: 3 / Formula: ZN
• Molecular weight: Theoretical: 65.409 Da

Macromolecule #93: FE2/S2 (INORGANIC) CLUSTER

• Macromolecule: Name: FE2/S2 (INORGANIC) CLUSTER / type: ligand / ID: 93 / Number of copies: 3 / Formula: FES
• Molecular weight: Theoretical: 175.82 Da

Chemical component information

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

Macromolecule #94: ADENOSINE-5'-TRIPHOSPHATE

• Macromolecule: Name: ADENOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 94 / Number of copies: 1 / Formula: ATP
• Molecular weight: Theoretical: 507.181 Da

Chemical component information

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

Macromolecule #95: GUANOSINE-5'-TRIPHOSPHATE

• Macromolecule: Name: GUANOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 95 / Number of copies: 1 / Formula: GTP
• Molecular weight: Theoretical: 523.18 Da

Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

Macromolecule #96: ALANINE

• Macromolecule: Name: ALANINE / type: ligand / ID: 96 / Number of copies: 1 / Formula: ALA
• Molecular weight: Theoretical: 89.093 Da

Chemical component information

ChemComp-ALA:
ALANINE

Macromolecule #97: water

• Macromolecule: Name: water / type: ligand / ID: 97 / Number of copies: 470 / Formula: HOH
• Molecular weight: Theoretical: 18.015 Da

Chemical component information

ChemComp-HOH:
WATER

Experimental details

Structure determination

• Method: cryo EM
• Processing: single particle reconstruction
• Aggregation state: particle

Sample preparation

Buffer

pH: 7.5
Component:

Concentration	Formula	Name
40.0 mM	KCl	Potassium chloride
25.0 mM	HEPES-KOH	4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid-potassium hydroxide buffer
5.0 mM	Mg(CH3COO)2	Magnesium acetate
0.05 %	C24H46O11	n-Dodecyl-beta-D-maltopyranoside
2.0 mM	C4H10O2S2	1,4-Dithio-D-threitol

• Grid: Model: Quantifoil R2/2 / Material: COPPER / Support film - Material: CARBON / Support film - topology: HOLEY / Support film - Film thickness: 3 / Pretreatment - Type: GLOW DISCHARGE
• Vitrification: Cryogen name: ETHANE / Chamber humidity: 100 % / Chamber temperature: 277 K / Instrument: FEI VITROBOT MARK IV

Electron microscopy

• Microscope: FEI TITAN KRIOS
• Specialist optics: Energy filter - Name: GIF Quantum LS / Energy filter - Slit width: 20 eV
• Image recording: Film or detector model: GATAN K2 SUMMIT (4k x 4k) / Detector mode: COUNTING / Digitization - Dimensions - Width: 3838 pixel / Digitization - Dimensions - Height: 3710 pixel / Digitization - Frames/image: 1-20 / Number grids imaged: 2 / Number real images: 19655 / Average exposure time: 4.0 sec. / Average electron dose: 30.0 e/Ų
• Electron beam: Acceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
• Electron optics: C2 aperture diameter: 70.0 µm / Calibrated defocus max: 3.6 µm / Calibrated defocus min: 0.2 µm / Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Cs: 2.7 mm / Nominal magnification: 165000
• Sample stage: Specimen holder model: FEI TITAN KRIOS AUTOGRID HOLDER / Cooling holder cryogen: NITROGEN
• Experimental equipment: Model: Titan Krios / Image courtesy: FEI Company

Image processing

• Particle selection: Number selected: 1308158

Startup model

Type of model: EMDB MAP
EMDB ID:

2876

• Final reconstruction: Number classes used: 1 / Applied symmetry - Point group: C₁ (asymmetric) / Resolution.type: BY AUTHOR / Resolution: 2.89 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: RELION (ver. 3.0) / Number images used: 30744
• Initial angle assignment: Type: PROJECTION MATCHING / Software - Name: RELION (ver. 2.1)
• Final angle assignment: Type: ANGULAR RECONSTITUTION / Software - Name: RELION (ver. 3.0)
• Final 3D classification: Number classes: 3 / Software - Name: RELION (ver. 3.0)

Atomic model buiding 1

Initial model

PDB ID	Chain
3j9m	source_name: PDB, initial_model_type: experimental model
5ool	source_name: PDB, initial_model_type: experimental model
6rw4	source_name: PDB, initial_model_type: experimental model

• Refinement: Space: REAL / Protocol: AB INITIO MODEL / Overall B value: 44 / Target criteria: Correlation coefficient

Output model

PDB-6zm5:
Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide