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- PDB-6zm6: Human mitochondrial ribosome in complex with mRNA, A/A tRNA and P... -

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Entry
Database: PDB / ID: 6zm6
TitleHuman mitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA
Components
  • (28S ribosomal protein ...) x 27
  • (39S ribosomal protein ...) x 48
  • 12S mitochondrial rRNA
  • 16S mitochondrial rRNA
  • A-site tRNA
  • Aurora kinase A-interacting protein
  • Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
  • Growth arrest and DNA damage-inducible proteins-interacting protein 1
  • P-site tRNA
  • Pentatricopeptide repeat domain-containing protein 3, mitochondrial
  • Peptidyl-tRNA hydrolase ICT1, mitochondrial
  • Ribosomal protein 63, mitochondrialRibosome
  • mRNAMessenger RNA
  • mitochondrial tRNAVal
KeywordsRIBOSOME / mitochondrion / translation / closed nascent-polypeptide tunnel
Function / homology
Function and homology information


rRNA import into mitochondrion / mitochondrial ribosome assembly / mitochondrial ribosome binding / mitochondrial transcription / mitochondrial translational termination / translation release factor activity, codon nonspecific / mitochondrial translational elongation / positive regulation of mitochondrial translation / mitochondrial ribosome / mitochondrial small ribosomal subunit ...rRNA import into mitochondrion / mitochondrial ribosome assembly / mitochondrial ribosome binding / mitochondrial transcription / mitochondrial translational termination / translation release factor activity, codon nonspecific / mitochondrial translational elongation / positive regulation of mitochondrial translation / mitochondrial ribosome / mitochondrial small ribosomal subunit / aminoacyl-tRNA hydrolase / Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters / aminoacyl-tRNA hydrolase activity / ribonuclease III activity / mitochondrial translation / primary miRNA processing / negative regulation of mitotic nuclear division / production of siRNA involved in RNA interference / mitochondrial large ribosomal subunit / pre-miRNA processing / mitotic cell cycle arrest / positive regulation of proteolysis / ribosomal small subunit binding / RNA processing / anatomical structure morphogenesis / cellular response to leukemia inhibitory factor / ribosome assembly / apoptotic signaling pathway / small ribosomal subunit rRNA binding / ribosomal small subunit assembly / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / fibrillar center / DNA damage response, detection of DNA damage / mRNA 5'-UTR binding / large ribosomal subunit rRNA binding / mRNA processing / ribosome biogenesis / cell population proliferation / large ribosomal subunit / ribosomal large subunit assembly / 5S rRNA binding / double-stranded RNA binding / cytosolic small ribosomal subunit / cell junction / regulation of translation / ribonucleoprotein complex / small ribosomal subunit / mitochondrial inner membrane / negative regulation of translation / tRNA binding / rRNA binding / ribosome / nuclear body / hydrolase activity / nuclear membrane / structural constituent of ribosome / mitochondrial matrix / translation / cell cycle / mRNA binding / intracellular membrane-bounded organelle / protein domain specific binding / GTP binding / nucleotide binding / apoptotic process / nucleolus / viral process / positive regulation of transcription, DNA-templated / mitochondrion / RNA binding / extracellular space / nucleoplasm / plasma membrane / nucleus / cytosol / cytoplasm
Ribosomal protein L28/L40, mitochondrial / Translation protein, beta-barrel domain superfamily / Ribosomal protein S12/S23 / Ribosomal protein L11, bacterial-type / Tim44-like domain / Ribosomal protein L49/IMG2 / Ribosomal protein/NADH dehydrogenase domain / Ribosomal protein S29, mitochondrial / Phosphatidylethanolamine-binding protein / Ribosomal protein L7/L12, oligomerisation ...Ribosomal protein L28/L40, mitochondrial / Translation protein, beta-barrel domain superfamily / Ribosomal protein S12/S23 / Ribosomal protein L11, bacterial-type / Tim44-like domain / Ribosomal protein L49/IMG2 / Ribosomal protein/NADH dehydrogenase domain / Ribosomal protein S29, mitochondrial / Phosphatidylethanolamine-binding protein / Ribosomal protein L7/L12, oligomerisation / Translation protein SH3-like domain superfamily / Ribosomal protein L9/RNase H1, N-terminal / Ribosomal protein L24/L26, conserved site / S15/NS1, RNA-binding / Cysteine alpha-hairpin motif superfamily / CHCH / Ribosomal protein L47, mitochondrial / Ribosomal protein L37/S30 / Zinc-binding ribosomal protein / Tetratricopeptide-like helical domain superfamily / Nucleic acid-binding, OB-fold / Beta-grasp domain superfamily / Ribosomal protein L30, bacterial-type / KOW / Nucleotide-binding alpha-beta plait domain superfamily / Ribosomal protein L24 / Ribosomal protein L10P / Ribosomal protein L19 / Ribosomal protein S2 / Ribosomal protein S21 / Ribosomal protein S11 / Ribosomal protein L4/L1e / Ribosomal protein L2 / Ribosomal protein L32p / Pentatricopeptide repeat / TGS / Ribosomal protein L13, bacterial-type / Ribosomal protein S15, bacterial-type / Ribosomal protein S5, C-terminal / Ribosomal protein L18 / Ribosomal protein S12, bacterial-type / Ribosomal protein S2, bacteria/mitochondria/plastid / Ribosomal protein L22, bacterial/chloroplast-type / Ribosomal protein L15, bacterial-type / Ribosomal protein L20 / Ribosomal protein L13 / TGS-like / Ribosomal protein L23/L15e core domain superfamily / Ribosomal protein L33 / Ribosomal protein L53, mitochondrial / 28S ribosomal protein S27, mitochondrial / Ribosomal protein L35, mitochondrial / 39S ribosomal protein L42, mitochondrial / Ribosomal protein S24/S35, mitochondrial, conserved domain / Ribosomal protein S23/S29, mitochondrial / Ribosomal protein L51, mitochondrial / Ribosomal protein S22, mitochondrial / Ribosomal protein S28, mitochondrial / Ribosomal protein S23, mitochondrial / Ribosomal protein L3, conserved site / Ribosomal protein L27/L41, mitochondrial / Ribosomal protein L3, bacterial/organelle-type / Ribosomal protein L9, N-terminal / Ribosomal protein S5 domain 2-type fold / Ribosomal protein S9, conserved site / Ribosomal protein L11, C-terminal / Ribosomal protein L11, N-terminal / Ribosomal protein L18e/L15P / Ribosomal protein L35 / Ribosomal protein L46, N-terminal / Ribosomal protein L13, conserved site / Ribosomal protein L55, mitochondrial / 50S ribosomal protein uL4 / Ribosomal protein S5 domain 2-type fold, subgroup / Ribosomal protein L25/L23 / Domain of unknown function DUF1713 / Ribosomal protein S27/S33, mitochondrial / Ribosomal protein S5, N-terminal / Ribosomal protein L7/L12, C-terminal / Ribosomal protein L37, mitochondrial / Translation elongation factor EF1B/ribosomal protein S6 / Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like / Double-stranded RNA-binding domain / Ribosomal protein L2, domain 2 / Growth arrest/ DNA-damage-inducible protein-interacting protein 1 / NUDIX hydrolase-like domain superfamily / Ribosomal protein L30, ferredoxin-like fold domain / Ribosomal protein L10e/L16 / Ribosomal protein 63, mitochondrial / Ribosomal S11, conserved site / Ribosomal protein S2, conserved site / Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily / Ribosomal protein S5, N-terminal, conserved site / Ribosomal protein S18, conserved site / Ribosomal protein L50, mitochondria / Ribosomal protein L21 / Ribosomal protein L27 / Ribosomal protein L2, C-terminal / PEBP-like superfamily / Ribosomal protein L30, ferredoxin-like fold domain superfamily
39S ribosomal protein L18, mitochondrial / 39S ribosomal protein L46, mitochondrial / 39S ribosomal protein L44, mitochondrial / Pentatricopeptide repeat domain-containing protein 3, mitochondrial / 39S ribosomal protein L47, mitochondrial / 39S ribosomal protein S30, mitochondrial / 39S ribosomal protein L40, mitochondrial / 39S ribosomal protein L17, mitochondrial / 39S ribosomal protein L37, mitochondrial / 39S ribosomal protein L20, mitochondrial ...39S ribosomal protein L18, mitochondrial / 39S ribosomal protein L46, mitochondrial / 39S ribosomal protein L44, mitochondrial / Pentatricopeptide repeat domain-containing protein 3, mitochondrial / 39S ribosomal protein L47, mitochondrial / 39S ribosomal protein S30, mitochondrial / 39S ribosomal protein L40, mitochondrial / 39S ribosomal protein L17, mitochondrial / 39S ribosomal protein L37, mitochondrial / 39S ribosomal protein L20, mitochondrial / 28S ribosomal protein S26, mitochondrial / 39S ribosomal protein L4, mitochondrial / 39S ribosomal protein L9, mitochondrial / 39S ribosomal protein L13, mitochondrial / Aurora kinase A-interacting protein / 39S ribosomal protein L32, mitochondrial / 39S ribosomal protein L45, mitochondrial / Ribosomal protein 63, mitochondrial / 39S ribosomal protein L34, mitochondrial / 39S ribosomal protein S18a, mitochondrial / 39S ribosomal protein L27, mitochondrial / 39S ribosomal protein L22, mitochondrial / 39S ribosomal protein L11, mitochondrial / gb:1858624630: / gb:1563835895: / 39S ribosomal protein L42, mitochondrial / 28S ribosomal protein S18b, mitochondrial / 28S ribosomal protein S23, mitochondrial / 28S ribosomal protein S18c, mitochondrial / 28S ribosomal protein S16, mitochondrial / 28S ribosomal protein S2, mitochondrial / 39S ribosomal protein L16, mitochondrial / 28S ribosomal protein S7, mitochondrial / 28S ribosomal protein S17, mitochondrial / 28S ribosomal protein S28, mitochondrial / 28S ribosomal protein S33, mitochondrial / 39S ribosomal protein L36, mitochondrial / 39S ribosomal protein L15, mitochondrial / 39S ribosomal protein L35, mitochondrial / 39S ribosomal protein L39, mitochondrial / 39S ribosomal protein L48, mitochondrial / 28S ribosomal protein S10, mitochondrial / 39S ribosomal protein L53, mitochondrial / 28S ribosomal protein S35, mitochondrial / 28S ribosomal protein S9, mitochondrial / 28S ribosomal protein S6, mitochondrial / 28S ribosomal protein S34, mitochondrial / 28S ribosomal protein S21, mitochondrial / 28S ribosomal protein S15, mitochondrial / 28S ribosomal protein S11, mitochondrial / 28S ribosomal protein S5, mitochondrial / 28S ribosomal protein S25, mitochondrial / 39S ribosomal protein L49, mitochondrial / 28S ribosomal protein S22, mitochondrial / 39S ribosomal protein L12, mitochondrial / 28S ribosomal protein S29, mitochondrial / 39S ribosomal protein L19, mitochondrial / 39S ribosomal protein L3, mitochondrial / 39S ribosomal protein L33, mitochondrial / 28S ribosomal protein S14, mitochondrial / 28S ribosomal protein S12, mitochondrial / 39S ribosomal protein L28, mitochondrial / Peptidyl-tRNA hydrolase ICT1, mitochondrial / 28S ribosomal protein S24, mitochondrial / 39S ribosomal protein L50, mitochondrial / 39S ribosomal protein L38, mitochondrial / Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 / 39S ribosomal protein L24, mitochondrial / 28S ribosomal protein S31, mitochondrial / 28S ribosomal protein S27, mitochondrial / 39S ribosomal protein L30, mitochondrial / Growth arrest and DNA damage-inducible proteins-interacting protein 1 / 39S ribosomal protein L43, mitochondrial / 39S ribosomal protein L41, mitochondrial / 39S ribosomal protein L23, mitochondrial / 39S ribosomal protein L52, mitochondrial / 39S ribosomal protein L10, mitochondrial / 39S ribosomal protein L55, mitochondrial / 39S ribosomal protein L21, mitochondrial / 39S ribosomal protein L14, mitochondrial / 39S ribosomal protein L54, mitochondrial / 39S ribosomal protein L2, mitochondrial / 39S ribosomal protein L51, mitochondrial / gb:1858624182:
Biological speciesHomo sapiens (human)
MethodELECTRON MICROSCOPY / single particle reconstruction / cryo EM / Resolution: 2.59 Å
Model detailsRibosome small subunit with initiation factors
AuthorsItoh, Y. / Andrell, J. / Amunts, A.
Funding support Sweden, 1items
OrganizationGrant numberCountry
European Research Council (ERC) Sweden
CitationJournal: Science / Year: 2021
Title: Mechanism of membrane-tethered mitochondrial protein synthesis.
Authors: Yuzuru Itoh / Juni Andréll / Austin Choi / Uwe Richter / Priyanka Maiti / Robert B Best / Antoni Barrientos / Brendan J Battersby / Alexey Amunts /
Abstract: Mitochondrial ribosomes (mitoribosomes) are tethered to the mitochondrial inner membrane to facilitate the cotranslational membrane insertion of the synthesized proteins. We report cryo-electron ...Mitochondrial ribosomes (mitoribosomes) are tethered to the mitochondrial inner membrane to facilitate the cotranslational membrane insertion of the synthesized proteins. We report cryo-electron microscopy structures of human mitoribosomes with nascent polypeptide, bound to the insertase oxidase assembly 1-like (OXA1L) through three distinct contact sites. OXA1L binding is correlated with a series of conformational changes in the mitoribosomal large subunit that catalyze the delivery of newly synthesized polypeptides. The mechanism relies on the folding of mL45 inside the exit tunnel, forming two specific constriction sites that would limit helix formation of the nascent chain. A gap is formed between the exit and the membrane, making the newly synthesized proteins accessible. Our data elucidate the basis by which mitoribosomes interact with the OXA1L insertase to couple protein synthesis and membrane delivery.
Validation Report
SummaryFull reportAbout validation report
History
DepositionJul 1, 2020Deposition site: PDBE / Processing site: PDBE
Revision 1.0Jan 13, 2021Provider: repository / Type: Initial release

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Assembly

Deposited unit
A: 16S mitochondrial rRNA
B: mitochondrial tRNAVal
D: 39S ribosomal protein L2, mitochondrial
E: 39S ribosomal protein L3, mitochondrial
F: 39S ribosomal protein L4, mitochondrial
H: 39S ribosomal protein L9, mitochondrial
I: 39S ribosomal protein L10, mitochondrial
J: 39S ribosomal protein L11, mitochondrial
K: 39S ribosomal protein L13, mitochondrial
L: 39S ribosomal protein L14, mitochondrial
M: 39S ribosomal protein L15, mitochondrial
N: 39S ribosomal protein L16, mitochondrial
O: 39S ribosomal protein L17, mitochondrial
P: 39S ribosomal protein L18, mitochondrial
Q: 39S ribosomal protein L19, mitochondrial
R: 39S ribosomal protein L20, mitochondrial
S: 39S ribosomal protein L21, mitochondrial
T: 39S ribosomal protein L22, mitochondrial
U: 39S ribosomal protein L23, mitochondrial
V: 39S ribosomal protein L24, mitochondrial
W: 39S ribosomal protein L27, mitochondrial
X: 39S ribosomal protein L28, mitochondrial
Y: 39S ribosomal protein L47, mitochondrial
Z: 39S ribosomal protein L30, mitochondrial
0: 39S ribosomal protein L32, mitochondrial
1: 39S ribosomal protein L33, mitochondrial
2: 39S ribosomal protein L34, mitochondrial
3: 39S ribosomal protein L35, mitochondrial
4: 39S ribosomal protein L36, mitochondrial
5: 39S ribosomal protein L37, mitochondrial
6: 39S ribosomal protein L38, mitochondrial
7: 39S ribosomal protein L39, mitochondrial
8: 39S ribosomal protein L40, mitochondrial
9: 39S ribosomal protein L41, mitochondrial
a: 39S ribosomal protein L42, mitochondrial
b: 39S ribosomal protein L43, mitochondrial
c: 39S ribosomal protein L44, mitochondrial
d: 39S ribosomal protein L45, mitochondrial
e: 39S ribosomal protein L46, mitochondrial
f: 39S ribosomal protein L48, mitochondrial
g: 39S ribosomal protein L49, mitochondrial
h: 39S ribosomal protein L50, mitochondrial
i: 39S ribosomal protein L51, mitochondrial
j: 39S ribosomal protein L52, mitochondrial
k: 39S ribosomal protein L53, mitochondrial
l: 39S ribosomal protein L54, mitochondrial
m: 39S ribosomal protein L55, mitochondrial
o: Ribosomal protein 63, mitochondrial
p: Peptidyl-tRNA hydrolase ICT1, mitochondrial
q: Growth arrest and DNA damage-inducible proteins-interacting protein 1
r: 39S ribosomal protein S18a, mitochondrial
s: 39S ribosomal protein S30, mitochondrial
t1: 39S ribosomal protein L12, mitochondrial
t2: 39S ribosomal protein L12, mitochondrial
t3: 39S ribosomal protein L12, mitochondrial
t4: 39S ribosomal protein L12, mitochondrial
t5: 39S ribosomal protein L12, mitochondrial
t6: 39S ribosomal protein L12, mitochondrial
AA: 12S mitochondrial rRNA
AB: 28S ribosomal protein S2, mitochondrial
AC: 28S ribosomal protein S24, mitochondrial
AD: 28S ribosomal protein S5, mitochondrial
AE: 28S ribosomal protein S6, mitochondrial
AF: 28S ribosomal protein S7, mitochondrial
AG: 28S ribosomal protein S9, mitochondrial
AH: 28S ribosomal protein S10, mitochondrial
AI: 28S ribosomal protein S11, mitochondrial
AJ: 28S ribosomal protein S12, mitochondrial
AK: 28S ribosomal protein S14, mitochondrial
AL: 28S ribosomal protein S15, mitochondrial
AM: 28S ribosomal protein S16, mitochondrial
AN: 28S ribosomal protein S17, mitochondrial
AO: 28S ribosomal protein S18b, mitochondrial
AP: 28S ribosomal protein S18c, mitochondrial
AQ: 28S ribosomal protein S21, mitochondrial
AR: 28S ribosomal protein S22, mitochondrial
AS: 28S ribosomal protein S23, mitochondrial
AT: 28S ribosomal protein S25, mitochondrial
AU: 28S ribosomal protein S26, mitochondrial
AV: 28S ribosomal protein S27, mitochondrial
AW: 28S ribosomal protein S28, mitochondrial
AX: 28S ribosomal protein S29, mitochondrial
AY: 28S ribosomal protein S31, mitochondrial
AZ: 28S ribosomal protein S33, mitochondrial
A0: 28S ribosomal protein S34, mitochondrial
A1: 28S ribosomal protein S35, mitochondrial
A2: Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
A3: Aurora kinase A-interacting protein
A4: Pentatricopeptide repeat domain-containing protein 3, mitochondrial
w: A-site tRNA
x: P-site tRNA
y: mRNA
hetero molecules


Theoretical massNumber of molelcules
Total (without water)3,069,299333
Polymers3,061,23192
Non-polymers8,068241
Water8,467470
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551

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Components

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RNA chain , 6 types, 6 molecules ABAAwxy

#1: RNA chain 16S mitochondrial rRNA


Mass: 500671.000 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: GenBank: 1563835895
#2: RNA chain mitochondrial tRNAVal


Mass: 22961.699 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: GenBank: 1858624630
#54: RNA chain 12S mitochondrial rRNA


Mass: 306120.094 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: GenBank: 1858624182
#85: RNA chain A-site tRNA


Mass: 21682.877 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human)
#86: RNA chain P-site tRNA


Mass: 22369.307 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human)
#87: RNA chain mRNA / Messenger RNA


Mass: 6003.530 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human)

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39S ribosomal protein ... , 48 types, 53 molecules DEFHIJKLMNOPQRSTUVWXYZ01234567...

#3: Protein 39S ribosomal protein L2, mitochondrial / Ribosome / MRP-L2 / Mitochondrial large ribosomal subunit protein uL2m


Mass: 33355.941 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q5T653
#4: Protein 39S ribosomal protein L3, mitochondrial / Ribosome / MRP-L3 / Mitochondrial large ribosomal subunit protein uL3m


Mass: 38689.562 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P09001
#5: Protein 39S ribosomal protein L4, mitochondrial / Ribosome / MRP-L4 / Mitochondrial large ribosomal subunit protein uL4m


Mass: 34970.195 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BYD3
#6: Protein 39S ribosomal protein L9, mitochondrial / Ribosome / MRP-L9 / Mitochondrial large ribosomal subunit protein bL9m


Mass: 30296.355 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BYD2
#7: Protein 39S ribosomal protein L10, mitochondrial / Ribosome / MRP-L10 / 39S ribosomal protein L8 / mitochondrial / MRP-L8 / Mitochondrial large ribosomal subunit ...MRP-L10 / 39S ribosomal protein L8 / mitochondrial / MRP-L8 / Mitochondrial large ribosomal subunit protein uL10m


Mass: 29322.529 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q7Z7H8
#8: Protein 39S ribosomal protein L11, mitochondrial / Ribosome / MRP-L11 / Mitochondrial large ribosomal subunit protein uL11m


Mass: 20716.227 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y3B7
#9: Protein 39S ribosomal protein L13, mitochondrial / Ribosome / MRP-L13 / Mitochondrial large ribosomal subunit protein uL13m


Mass: 20633.824 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BYD1
#10: Protein 39S ribosomal protein L14, mitochondrial / Ribosome / MRP-L14 / 39S ribosomal protein L32 / mitochondrial / MRP-L32 / Mitochondrial large ribosomal ...MRP-L14 / 39S ribosomal protein L32 / mitochondrial / MRP-L32 / Mitochondrial large ribosomal subunit protein uL14m


Mass: 15973.702 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q6P1L8
#11: Protein 39S ribosomal protein L15, mitochondrial / Ribosome / MRP-L15 / Mitochondrial large ribosomal subunit protein uL15m


Mass: 33473.820 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9P015
#12: Protein 39S ribosomal protein L16, mitochondrial / Ribosome / MRP-L16 / Mitochondrial large ribosomal subunit protein uL16m


Mass: 28496.285 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9NX20
#13: Protein 39S ribosomal protein L17, mitochondrial / Ribosome / MRP-L17 / LYST-interacting protein 2 / Mitochondrial large ribosomal subunit protein bL17m


Mass: 20083.266 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9NRX2
#14: Protein 39S ribosomal protein L18, mitochondrial / Ribosome / MRP-L18 / Mitochondrial large ribosomal subunit protein uL18m


Mass: 20607.570 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9H0U6
#15: Protein 39S ribosomal protein L19, mitochondrial / Ribosome / MRP-L19 / 39S ribosomal protein L15 / mitochondrial / MRP-L15 / Mitochondrial large ribosomal ...MRP-L19 / 39S ribosomal protein L15 / mitochondrial / MRP-L15 / Mitochondrial large ribosomal subunit protein bL19m


Mass: 33584.996 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P49406
#16: Protein 39S ribosomal protein L20, mitochondrial / Ribosome / MRP-L20 / Mitochondrial large ribosomal subunit protein bL20m


Mass: 17479.654 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BYC9
#17: Protein 39S ribosomal protein L21, mitochondrial / Ribosome / MRP-L21 / Mitochondrial large ribosomal subunit protein bL21m


Mass: 22847.682 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q7Z2W9
#18: Protein 39S ribosomal protein L22, mitochondrial / Ribosome / MRP-L22 / 39S ribosomal protein L25 / mitochondrial / MRP-L25 / Mitochondrial large ribosomal ...MRP-L22 / 39S ribosomal protein L25 / mitochondrial / MRP-L25 / Mitochondrial large ribosomal subunit protein uL22m


Mass: 23683.732 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9NWU5
#19: Protein 39S ribosomal protein L23, mitochondrial / Ribosome / MRP-L23 / L23 mitochondrial-related protein / Mitochondrial large ribosomal subunit protein uL23m / ...MRP-L23 / L23 mitochondrial-related protein / Mitochondrial large ribosomal subunit protein uL23m / Ribosomal protein L23-like


Mass: 17718.029 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q16540
#20: Protein 39S ribosomal protein L24, mitochondrial / Ribosome / MRP-L24 / Mitochondrial large ribosomal subunit protein uL24m


Mass: 24953.875 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q96A35
#21: Protein 39S ribosomal protein L27, mitochondrial / Ribosome / MRP-L27 / Mitochondrial large ribosomal subunit protein bL27m


Mass: 16102.859 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9P0M9
#22: Protein 39S ribosomal protein L28, mitochondrial / Ribosome / MRP-L28 / Melanoma antigen p15 / Melanoma-associated antigen recognized by T-lymphocytes / ...MRP-L28 / Melanoma antigen p15 / Melanoma-associated antigen recognized by T-lymphocytes / Mitochondrial large ribosomal subunit protein bL28m


Mass: 30202.867 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q13084
#23: Protein 39S ribosomal protein L47, mitochondrial / Ribosome / MRP-L47 / Mitochondrial large ribosomal subunit protein uL29m / Nasopharyngeal carcinoma metastasis- ...MRP-L47 / Mitochondrial large ribosomal subunit protein uL29m / Nasopharyngeal carcinoma metastasis-related protein 1


Mass: 29508.535 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9HD33
#24: Protein 39S ribosomal protein L30, mitochondrial / Ribosome / MRP-L30 / 39S ribosomal protein L28 / mitochondrial / MRP-L28 / Mitochondrial large ribosomal ...MRP-L30 / 39S ribosomal protein L28 / mitochondrial / MRP-L28 / Mitochondrial large ribosomal subunit protein uL30m


Mass: 18582.812 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q8TCC3
#25: Protein 39S ribosomal protein L32, mitochondrial / Ribosome / MRP-L32 / Mitochondrial large ribosomal subunit protein bL32m


Mass: 21437.799 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BYC8
#26: Protein 39S ribosomal protein L33, mitochondrial / Ribosome / MRP-L33 / Mitochondrial large ribosomal subunit protein bL33m


Mass: 7635.204 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: O75394
#27: Protein 39S ribosomal protein L34, mitochondrial / Ribosome / MRP-L34 / Mitochondrial large ribosomal subunit protein bL34m


Mass: 10183.913 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BQ48
#28: Protein 39S ribosomal protein L35, mitochondrial / Ribosome / MRP-L35 / Mitochondrial large ribosomal subunit protein bL35m


Mass: 21558.488 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9NZE8
#29: Protein 39S ribosomal protein L36, mitochondrial / Ribosome / MRP-L36 / BRCA1-interacting protein 1 / Mitochondrial large ribosomal subunit protein bL36m


Mass: 11809.301 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9P0J6
#30: Protein 39S ribosomal protein L37, mitochondrial / Ribosome / MRP-L37 / 39S ribosomal protein L2 / mitochondrial / MRP-L2 / Mitochondrial large ribosomal subunit ...MRP-L37 / 39S ribosomal protein L2 / mitochondrial / MRP-L2 / Mitochondrial large ribosomal subunit protein mL37


Mass: 48183.344 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BZE1
#31: Protein 39S ribosomal protein L38, mitochondrial / Ribosome / MRP-L38 / Mitochondrial large ribosomal subunit protein mL38


Mass: 44659.430 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q96DV4
#32: Protein 39S ribosomal protein L39, mitochondrial / Ribosome / MRP-L39 / 39S ribosomal protein L5 / mitochondrial / MRP-L5 / Mitochondrial large ribosomal subunit ...MRP-L39 / 39S ribosomal protein L5 / mitochondrial / MRP-L5 / Mitochondrial large ribosomal subunit protein mL39


Mass: 38764.785 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9NYK5
#33: Protein 39S ribosomal protein L40, mitochondrial / Ribosome / MRP-L40 / Mitochondrial large ribosomal subunit protein mL40 / Nuclear localization signal- ...MRP-L40 / Mitochondrial large ribosomal subunit protein mL40 / Nuclear localization signal-containing protein deleted in velocardiofacial syndrome / Up-regulated in metastasis


Mass: 24534.422 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9NQ50
#34: Protein 39S ribosomal protein L41, mitochondrial / Ribosome / MRP-L41 / 39S ribosomal protein L27 homolog / Bcl-2-interacting mitochondrial ribosomal protein L41 ...MRP-L41 / 39S ribosomal protein L27 homolog / Bcl-2-interacting mitochondrial ribosomal protein L41 / Cell proliferation-inducing gene 3 protein / MRP-L27 homolog / Mitochondrial large ribosomal subunit protein mL41


Mass: 15404.708 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q8IXM3
#35: Protein 39S ribosomal protein L42, mitochondrial / Ribosome / MRP-L42 / 39S ribosomal protein L31 / mitochondrial / MRP-L31 / Mitochondrial large ribosomal ...MRP-L42 / 39S ribosomal protein L31 / mitochondrial / MRP-L31 / Mitochondrial large ribosomal subunit protein mL42


Mass: 16691.176 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y6G3
#36: Protein 39S ribosomal protein L43, mitochondrial / Ribosome / MRP-L43 / Mitochondrial large ribosomal subunit protein mL43 / Mitochondrial ribosomal protein bMRP36a


Mass: 23368.631 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q8N983
#37: Protein 39S ribosomal protein L44, mitochondrial / Ribosome / MRP-L44 / Mitochondrial large ribosomal subunit protein mL44


Mass: 37583.312 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human)
References: UniProt: Q9H9J2, Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters
#38: Protein 39S ribosomal protein L45, mitochondrial / Ribosome / MRP-L45 / Mitochondrial large ribosomal subunit protein mL45


Mass: 35402.918 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BRJ2
#39: Protein 39S ribosomal protein L46, mitochondrial / Ribosome / MRP-L46 / Mitochondrial large ribosomal subunit protein mL46 / P2ECSL


Mass: 31748.107 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9H2W6
#40: Protein 39S ribosomal protein L48, mitochondrial / Ribosome / MRP-L48 / Mitochondrial large ribosomal subunit protein mL48


Mass: 23970.814 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q96GC5
#41: Protein 39S ribosomal protein L49, mitochondrial / Ribosome / MRP-L49 / Mitochondrial large ribosomal subunit protein mL49 / Neighbor of FAU / NOF / Protein NOF1


Mass: 19225.043 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q13405
#42: Protein 39S ribosomal protein L50, mitochondrial / Ribosome / MRP-L50 / Mitochondrial large ribosomal subunit protein mL50


Mass: 18349.943 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q8N5N7
#43: Protein 39S ribosomal protein L51, mitochondrial / Ribosome / MRP-L51 / Mitochondrial large ribosomal subunit protein mL51 / bMRP-64 / bMRP64


Mass: 15125.917 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q4U2R6
#44: Protein 39S ribosomal protein L52, mitochondrial / Ribosome / MRP-L52 / Mitochondrial large ribosomal subunit protein mL52


Mass: 13682.658 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q86TS9
#45: Protein 39S ribosomal protein L53, mitochondrial / Ribosome / MRP-L53 / Mitochondrial large ribosomal subunit protein mL53


Mass: 12036.701 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q96EL3
#46: Protein 39S ribosomal protein L54, mitochondrial / Ribosome / MRP-L54 / Mitochondrial large ribosomal subunit protein mL54


Mass: 15844.178 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q6P161
#47: Protein 39S ribosomal protein L55, mitochondrial / Ribosome / MRP-L55 / Mitochondrial large ribosomal subunit protein bL31m / Mitochondrial large ribosomal ...MRP-L55 / Mitochondrial large ribosomal subunit protein bL31m / Mitochondrial large ribosomal subunit protein mL55


Mass: 15160.433 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q7Z7F7
#51: Protein 39S ribosomal protein S18a, mitochondrial / Ribosome / S18mt-a / 39S ribosomal protein S18-3 / mitochondrial / MRP-S18-3 / Mitochondrial large ribosomal ...S18mt-a / 39S ribosomal protein S18-3 / mitochondrial / MRP-S18-3 / Mitochondrial large ribosomal subunit protein bS18a / Mitochondrial large ribosomal subunit protein mL66


Mass: 22224.078 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9NVS2
#52: Protein 39S ribosomal protein S30, mitochondrial / Ribosome / S30mt / Mitochondrial large ribosomal subunit protein mL65 / Mitochondrial large ribosomal subunit ...S30mt / Mitochondrial large ribosomal subunit protein mL65 / Mitochondrial large ribosomal subunit protein mS30 / Programmed cell death protein 9


Mass: 50429.578 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9NP92
#53: Protein
39S ribosomal protein L12, mitochondrial / Ribosome / MRP-L12 / 5c5-2 / Mitochondrial large ribosomal subunit protein bL12m


Mass: 21378.164 Da / Num. of mol.: 6 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P52815

+
Protein , 6 types, 6 molecules opqA2A3A4

#48: Protein Ribosomal protein 63, mitochondrial / Ribosome / hMRP63 / Mitochondrial large ribosomal subunit protein mL63 / Mitochondrial ribosomal protein 63 / ...hMRP63 / Mitochondrial large ribosomal subunit protein mL63 / Mitochondrial ribosomal protein 63 / Mitochondrial ribosomal protein L57


Mass: 12292.333 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BQC6
#49: Protein Peptidyl-tRNA hydrolase ICT1, mitochondrial / 39S ribosomal protein L58 / mitochondrial / MRP-L58 / Digestion substraction 1 / DS-1 / Immature ...39S ribosomal protein L58 / mitochondrial / MRP-L58 / Digestion substraction 1 / DS-1 / Immature colon carcinoma transcript 1 protein / Mitochondrial large ribosomal subunit protein mL62


Mass: 23674.203 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q14197, aminoacyl-tRNA hydrolase
#50: Protein Growth arrest and DNA damage-inducible proteins-interacting protein 1 / 39S ribosomal protein L59 / mitochondrial / MRP-L59 / CKII beta-associating protein / CR6- ...39S ribosomal protein L59 / mitochondrial / MRP-L59 / CKII beta-associating protein / CR6-interacting factor 1 / CRIF1 / Mitochondrial large ribosomal subunit protein mL64 / Papillomavirus L2-interacting nuclear protein 1 / PLINP-1 / p53-responsive gene 6 protein


Mass: 25426.895 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q8TAE8
#82: Protein Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 / 28S ribosomal protein S37 / mitochondrial / MRP-S37 / Mitochondrial small ribosomal subunit protein ...28S ribosomal protein S37 / mitochondrial / MRP-S37 / Mitochondrial small ribosomal subunit protein mS37 / Nuclear protein C2360


Mass: 13409.661 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q96BP2
#83: Protein Aurora kinase A-interacting protein / AURKA-interacting protein / 28S ribosomal protein S38 / mitochondrial / MRP-S38 / Mitochondrial ...AURKA-interacting protein / 28S ribosomal protein S38 / mitochondrial / MRP-S38 / Mitochondrial small ribosomal subunit protein mS38


Mass: 22395.326 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9NWT8
#84: Protein Pentatricopeptide repeat domain-containing protein 3, mitochondrial / 28S ribosomal protein S39 / mitochondrial / MRP-S39 / Mitochondrial small ribosomal subunit protein ...28S ribosomal protein S39 / mitochondrial / MRP-S39 / Mitochondrial small ribosomal subunit protein mS39 / Transformation-related gene 15 protein / TRG-15


Mass: 78648.547 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q96EY7

+
28S ribosomal protein ... , 27 types, 27 molecules ABACADAEAFAGAHAIAJAKALAMANAOAPAQARASATAUAVAWAXAYAZA0A1

#55: Protein 28S ribosomal protein S2, mitochondrial / Ribosome / S2mt / Mitochondrial small ribosomal subunit protein uS2m


Mass: 33298.238 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y399
#56: Protein 28S ribosomal protein S24, mitochondrial / Ribosome / S24mt / Mitochondrial small ribosomal subunit protein uS3m / bMRP-47 / bMRP47


Mass: 19046.164 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q96EL2
#57: Protein 28S ribosomal protein S5, mitochondrial / Ribosome / S5mt / Mitochondrial small ribosomal subunit protein uS5m


Mass: 48094.594 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P82675
#58: Protein 28S ribosomal protein S6, mitochondrial / Ribosome / S6mt / Mitochondrial small ribosomal subunit protein bS6m


Mass: 14250.588 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P82932
#59: Protein 28S ribosomal protein S7, mitochondrial / Ribosome / S7mt / Mitochondrial small ribosomal subunit protein uS7m / bMRP-27a / bMRP27a


Mass: 28186.154 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y2R9
#60: Protein 28S ribosomal protein S9, mitochondrial / Ribosome / S9mt / Mitochondrial small ribosomal subunit protein uS9m


Mass: 45909.859 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P82933
#61: Protein 28S ribosomal protein S10, mitochondrial / Ribosome / S10mt / Mitochondrial small ribosomal subunit protein uS10m


Mass: 23033.500 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P82664
#62: Protein 28S ribosomal protein S11, mitochondrial / Ribosome / S11mt / Cervical cancer proto-oncogene 2 protein / HCC-2 / Mitochondrial small ribosomal subunit protein uS11m


Mass: 20649.779 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P82912
#63: Protein 28S ribosomal protein S12, mitochondrial / Ribosome / S12mt / MT-RPS12 / Mitochondrial small ribosomal subunit protein uS12m


Mass: 15200.947 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: O15235
#64: Protein 28S ribosomal protein S14, mitochondrial / Ribosome / S14mt / Mitochondrial small ribosomal subunit protein uS14m


Mass: 15168.788 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: O60783
#65: Protein 28S ribosomal protein S15, mitochondrial / Ribosome / S15mt / Mitochondrial small ribosomal subunit protein uS15m


Mass: 29903.293 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P82914
#66: Protein 28S ribosomal protein S16, mitochondrial / Ribosome / S16mt / Mitochondrial small ribosomal subunit protein bS16m


Mass: 15371.899 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y3D3
#67: Protein 28S ribosomal protein S17, mitochondrial / Ribosome / S17mt / Mitochondrial small ribosomal subunit protein uS17m


Mass: 14526.078 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y2R5
#68: Protein 28S ribosomal protein S18b, mitochondrial / Ribosome / S18mt-b / 28S ribosomal protein S18-2 / mitochondrial / MRP-S18-2 / Mitochondrial small ribosomal ...S18mt-b / 28S ribosomal protein S18-2 / mitochondrial / MRP-S18-2 / Mitochondrial small ribosomal subunit protein bS18b / Mitochondrial small ribosomal subunit protein mS40


Mass: 29440.629 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y676
#69: Protein 28S ribosomal protein S18c, mitochondrial / Ribosome / S18mt-c / 28S ribosomal protein S18-1 / mitochondrial / MRP-S18-1 / Mitochondrial small ribosomal ...S18mt-c / 28S ribosomal protein S18-1 / mitochondrial / MRP-S18-1 / Mitochondrial small ribosomal subunit protein bS18c / Mitochondrial small ribosomal subunit protein bS18m


Mass: 15876.786 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y3D5
#70: Protein 28S ribosomal protein S21, mitochondrial / Ribosome / S21mt / Mitochondrial small ribosomal subunit protein bS21m


Mass: 10675.494 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / Variant: Natural variant Cys50Arg / References: UniProt: P82921
#71: Protein 28S ribosomal protein S22, mitochondrial / Ribosome / S22mt / Mitochondrial small ribosomal subunit protein mS22


Mass: 41337.316 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P82650
#72: Protein 28S ribosomal protein S23, mitochondrial / Ribosome / S23mt / Mitochondrial small ribosomal subunit protein mS23


Mass: 21805.664 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y3D9
#73: Protein 28S ribosomal protein S25, mitochondrial / Ribosome / S25mt / Mitochondrial small ribosomal subunit protein mS25


Mass: 20146.428 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P82663
#74: Protein 28S ribosomal protein S26, mitochondrial / Ribosome / S26mt / 28S ribosomal protein S13 / mitochondrial / S13mt / Mitochondrial small ribosomal subunit protein mS26


Mass: 24259.820 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9BYN8
#75: Protein 28S ribosomal protein S27, mitochondrial / Ribosome / S27mt / Mitochondrial ribosomal protein S27 / Mitochondrial small ribosomal subunit protein mS27


Mass: 47669.262 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q92552
#76: Protein 28S ribosomal protein S28, mitochondrial / Ribosome / S28mt / 28S ribosomal protein S35 / mitochondrial / S35mt / Mitochondrial small ribosomal subunit protein bS1m


Mass: 20878.846 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y2Q9
#77: Protein 28S ribosomal protein S29, mitochondrial / Ribosome / S29mt / Death-associated protein 3 / DAP-3 / Ionizing radiation resistance conferring protein / ...S29mt / Death-associated protein 3 / DAP-3 / Ionizing radiation resistance conferring protein / Mitochondrial small ribosomal subunit protein mS29


Mass: 45634.406 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P51398
#78: Protein 28S ribosomal protein S31, mitochondrial / Ribosome / S31mt / Imogen 38 / Mitochondrial small ribosomal subunit protein mS31


Mass: 45391.473 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q92665
#79: Protein 28S ribosomal protein S33, mitochondrial / Ribosome / S33mt / Mitochondrial small ribosomal subunit protein mS33


Mass: 12657.776 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y291
#80: Protein 28S ribosomal protein S34, mitochondrial / Ribosome / S34mt / Mitochondrial small ribosomal subunit protein mS34


Mass: 25695.549 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P82930
#81: Protein 28S ribosomal protein S35, mitochondrial / Ribosome / S35mt / 28S ribosomal protein S28 / mitochondrial / S28mt / Mitochondrial small ribosomal subunit protein mS35


Mass: 36898.328 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: cell / Source: (natural) Homo sapiens (human) / References: UniProt: P82673

+
Non-polymers , 7 types, 711 molecules

#88: Chemical...
ChemComp-MG / MAGNESIUM ION / Magnesium


Mass: 24.305 Da / Num. of mol.: 189 / Source method: obtained synthetically / Formula: Mg
#89: Chemical...
ChemComp-K / POTASSIUM ION / Potassium


Mass: 39.098 Da / Num. of mol.: 44 / Source method: obtained synthetically / Formula: K
#90: Chemical ChemComp-ZN / ZINC ION / Zinc


Mass: 65.409 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: Zn
#91: Chemical ChemComp-FES / FE2/S2 (INORGANIC) CLUSTER / Iron–sulfur cluster


Mass: 175.820 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: Fe2S2
#92: Chemical ChemComp-ATP / ADENOSINE-5'-TRIPHOSPHATE / Adenosine triphosphate


Mass: 507.181 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C10H16N5O13P3 / Comment: ATP, energy-carrying molecule*YM
#93: Chemical ChemComp-GTP / GUANOSINE-5'-TRIPHOSPHATE / Guanosine triphosphate


Mass: 523.180 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C10H16N5O14P3 / Comment: GTP, energy-carrying molecule*YM
#94: Water ChemComp-HOH / water / Water


Mass: 18.015 Da / Num. of mol.: 470 / Source method: isolated from a natural source / Formula: H2O

+
Details

Has ligand of interestN

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Experimental details

-
Experiment

ExperimentMethod: ELECTRON MICROSCOPY
EM experimentAggregation state: PARTICLE / 3D reconstruction method: single particle reconstruction

-
Sample preparation

Component
IDNameTypeDetailsEntity IDParent-IDSource
1Ribosome with mRNA and tRNAsRIBOSOMEMitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA#1-#870NATURAL
2Large subunit of ribosomeCOMPLEX#1-#531NATURAL
3Small subunit of ribosomeCOMPLEX#54-#841NATURAL
Molecular weight
IDEntity assembly-IDValue (°)Experimental value
113 MDaNO
212 MDaNO
Source (natural)
IDEntity assembly-IDOrganismNcbi tax-ID
11Homo sapiens (human)9606
22Homo sapiens (human)9606
33Homo sapiens (human)9606
Buffer solutionpH: 7.5
Buffer component
IDConc.NameFormulaBuffer-ID
140 mMPotassium chlorideKCl1
225 mM4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid-potassium hydroxide bufferHEPES-KOH1
35.0 mMMagnesium acetateMg(CH3COO)21
40.05 %n-Dodecyl-beta-D-maltopyranosideC24H46O111
52 mM1,4-Dithio-D-threitolC4H10O2S21
SpecimenEmbedding applied: NO / Shadowing applied: NO / Staining applied: NO / Vitrification applied: YES
Specimen supportGrid material: COPPER / Grid type: Quantifoil R2/2
VitrificationInstrument: FEI VITROBOT MARK IV / Cryogen name: ETHANE / Humidity: 100 % / Chamber temperature: 277 K

-
Electron microscopy imaging

Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company
MicroscopyModel: FEI TITAN KRIOS
Electron gunElectron source: FIELD EMISSION GUN / Accelerating voltage: 300 kV / Illumination mode: FLOOD BEAM
Electron lensMode: BRIGHT FIELDBright-field microscopy / Nominal magnification: 165000 X / Calibrated defocus min: 200 nm / Calibrated defocus max: 3600 nm / Cs: 2.7 mm / C2 aperture diameter: 70 µm / Alignment procedure: ZEMLIN TABLEAU
Specimen holderCryogen: NITROGEN / Model: FEI TITAN KRIOS AUTOGRID HOLDER
Image recordingAverage exposure time: 4 sec. / Electron dose: 30 e/Å2 / Detector mode: COUNTING / Film or detector model: GATAN K2 SUMMIT (4k x 4k) / Num. of grids imaged: 2 / Num. of real images: 19655
EM imaging opticsEnergyfilter name: GIF Quantum LS / Energyfilter slit width: 20 eV
Image scansWidth: 3838 / Height: 3710 / Movie frames/image: 20 / Used frames/image: 1-20

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Processing

EM software
IDNameVersionCategory
1Warpparticle selection
2EPUimage acquisition
4Gctf1.06CTF correction
7Coot0.9-pre ELmodel fitting
9PHENIX1.17.1-3660model refinement
10RELION2.1initial Euler assignment
11RELION3final Euler assignment
12RELION3classification
13RELION33D reconstruction
CTF correctionType: PHASE FLIPPING AND AMPLITUDE CORRECTION
Particle selectionNum. of particles selected: 1308158
SymmetryPoint symmetry: C1 (asymmetric)
3D reconstructionResolution: 2.59 Å / Resolution method: FSC 0.143 CUT-OFF / Num. of particles: 93615 / Num. of class averages: 1 / Symmetry type: POINT
Atomic model buildingB value: 44 / Protocol: AB INITIO MODEL / Space: REAL / Target criteria: Correlation coefficient
Atomic model building
IDPDB-ID3D fitting-ID
13J9M1
25OOL1
36RW41

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