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TitleMechanism of lipid transfer by bridge-like protein VPS13A and the scramblase XK.
Journal, issue, pagesCell, Year 2026
Publish dateSep 27, 2025 (structure data deposition date)
AuthorsBodan Hu / Daniel Álvarez / Cristian Rocha-Roa / Valentin Guyard / Dazhi Li / Yara Ahmed / Xinbo Wang / Pietro De Camilli / Stefano Vanni / Karin M Reinisch /
PubMed AbstractIn eukaryotes, bridge-like lipid-transfer proteins (BLTPs) are central in mediating vesicle-independent lipid transfer between organelles. BLTPs span the cytosolic space between organelles at contact ...In eukaryotes, bridge-like lipid-transfer proteins (BLTPs) are central in mediating vesicle-independent lipid transfer between organelles. BLTPs span the cytosolic space between organelles at contact sites, featuring hydrophobic channels for lipids to travel between membranes. How BLTPs cooperate with partner proteins to orchestrate lipid delivery remains a mystery. Here, we used cryo-electron microscopy to visualize a complex comprising the prototypical BLTP VPS13A and the plasma membrane-localized scramblase XK at near-atomic resolution. VPS13A interacts with XK via its pleckstrin homology domain, priming VPS13A's bridge-like lipid-transfer domain to deliver lipids directly to the cytosolic leaflet of the acceptor membrane. In molecular dynamics simulations, this arrangement allows for robust lipid transfer. Newly delivered lipids can then be equilibrated between leaflets of the membrane bilayer by the scramblase, allowing for membrane growth. Mechanistic insights regarding lipid delivery by VPS13A are directly applicable to all VPS13 proteins and, more broadly, to all BLTP family members.
External linksCell / PubMed:42285089 / PubMed Central
MethodsEM (single particle)
Resolution3.21 - 3.41 Å
Structure data

PDB-9yfw:
VPS13A central bridge domain
Method: ELECTRON MICROSCOPY / Resolution: 3.21 Å

PDB-9yg4:
VPS13A/Nt-CaM
Method: ELECTRON MICROSCOPY / Resolution: 3.38 Å

PDB-9yg5:
VPS13A/Ct-XKR1
Method: ELECTRON MICROSCOPY / Resolution: 3.41 Å

Source
  • homo sapiens (human)
KeywordsLIPID TRANSPORT / VPS13A / BLTP / RBG motif / Calmodulin / Complex / ER / XKR1 / BLTPs / Scrambles

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