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Structure paper

TitleStructural mechanisms for inhibition and activation of human small-conductance Ca-activated potassium channel SK2.
Journal, issue, pagesNat Commun, Vol. 17, Issue 1, Page 1770, Year 2026
Publish dateJan 15, 2026
AuthorsBao Ma / Di Wu / En Cao / Cheng Chi / Zhihao Wang / Zhanyi Xia / Long-Hua Sun / Bingxing Pan / Daohua Jiang / Wenhua Zhang /
PubMed AbstractThe small-conductance calcium-activated potassium (SK1-3 or K2) channels regulate the intrinsic excitability and firing frequency of excitable cells. SK channels are modulated by a variety of ...The small-conductance calcium-activated potassium (SK1-3 or K2) channels regulate the intrinsic excitability and firing frequency of excitable cells. SK channels are modulated by a variety of distinct modulators; however, the underlying mechanisms remain elusive. Here, we present four cryoelectron microscopy structures of the human SK2-calmodulin complex bound with apamin, UCL1684, AP30663, and CAD-1883, elucidating their distinct binding sites and regulatory mechanisms. Apamin and UCL1684 compete for a similar binding site above the selectivity filter, which is formed by the distinct S3-S4 linker of SK2. CAD-1883 glues the N-lobe of calmodulin and the S4-S5 linker of SK2, reinforcing the open state. In contrast, AP30663 resides in the central cavity of SK2, blocking ion conductance. This study reveals multiple modulation sites in SK2 and the molecular mechanisms for the inhibition and potentiation of SK channels, which could advance rational drug design targeting SK2 channel for the treatment of cardiovascular and neurological disorders.
External linksNat Commun / PubMed:41540047 / PubMed Central
MethodsEM (single particle)
Resolution2.96 - 3.35 Å
Structure data

65356

9vu9

EMDB-65356, PDB-9vu9:
channel D complex with 4
Method: EM (single particle) / Resolution: 3.34 Å

65357

9vua

EMDB-65357, PDB-9vua:
channel A complex with 1
Method: EM (single particle) / Resolution: 3.23 Å

65358

9vub

EMDB-65358, PDB-9vub:
channel C complex with 3
Method: EM (single particle) / Resolution: 3.35 Å

65359

9vuc

EMDB-65359, PDB-9vuc:
channel B complex with 2
Method: EM (single particle) / Resolution: 2.96 Å

Chemicals

PDB-1etx:
THE CRYSTAL STRUCTURE OF E. COLI FIS MUTANT Q74A

ChemComp-K:
Unknown entry

ChemComp-POV:
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate / phospholipid*YM

ChemComp-CLR:
CHOLESTEROL

ChemComp-CA:
Unknown entry

PDB-1b92:
MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY


ChemComp, No image

ChemComp-Y7Z:
Unknown entry

Source
  • homo sapiens (human)
  • apis mellifera (honey bee)
KeywordsMEMBRANE PROTEIN / channel D complex with 4 / channel A complex with 1 / channel C complex with 3 / channel B complex with 2

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