EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Noncanonical agonist-dependent and -independent arrestin recruitment of GPR1.
ジャーナル・号・ページ	Science, Vol. 390, Issue 6775, Page eadt8794, Year 2025
掲載日	2025年11月20日
著者	Heng Cai / Xiaowen Lin / Lechen Zhao / Maozhou He / Jie Yu / Bingjie Zhang / Yuandi Ma / Xiaohua Chang / Yuxuan Tang / Tianyu Luo / Jie Jiang / Mengna Ma / Wenqi Song / Limin Ma / Xiaojing Chu / Cuiying Yi / Kun Chen / Shuo Han / Cen Xie / Wenqing Shui / Qiang Zhao / Ya Zhu / Beili Wu /
PubMed 要旨	G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors have diverse signaling properties with differential preferences for downstream pathways. Certain receptors, such as the ...G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors have diverse signaling properties with differential preferences for downstream pathways. Certain receptors, such as the chemerin receptor GPR1, undergo arrestin-mediated internalization but weak G protein signaling. However, the mechanisms of this unusual signaling pattern and its physiological relevance are unclear. We report the structures of GPR1 bound to chemerin and β-arrestin 1 or β-arrestin 2 and an agonist-free GPR1-β-arrestin 1 complex. Upon agonist stimulation, the receptor binds the two arrestins in distinct interaction patterns, which may account for their differential cellular responses. Agonist-independent internalization was mediated by an inactive, constitutively phosphorylated GPR1 that accommodates β-arrestin 1 in an unconventional pocket together with a fatty acid, which potentially provides a basis for GPR1 modulating lipid accumulation in lipid-overloaded adipocytes.
リンク	Science / PubMed:41264711
手法	EM (単粒子)
解像度	2.9 - 3.5 Å
構造データ	64610 9uyh EMDB-64610, PDB-9uyh: Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 1) 手法: EM (単粒子) / 解像度: 3.3 Å 64611 9uyi EMDB-64611, PDB-9uyi: Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 2) 手法: EM (単粒子) / 解像度: 3.2 Å 64612 9uyj EMDB-64612, PDB-9uyj: Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 3) 手法: EM (単粒子) / 解像度: 3.3 Å 64614 9uyl EMDB-64614, PDB-9uyl: Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 4) 手法: EM (単粒子) / 解像度: 3.3 Å EMDB-64615: Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 2 (focused refinement in chemerin and GPR1) 手法: EM (単粒子) / 解像度: 3.5 Å EMDB-64616: Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 2 (focused refinement in beta-arrestin 2) 手法: EM (単粒子) / 解像度: 3.2 Å EMDB-64617: Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 2 (consensus refinement) 手法: EM (単粒子) / 解像度: 3.4 Å 64618 9uym EMDB-64618, PDB-9uym: Composite map of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 2 手法: EM (単粒子) / 解像度: 3.5 Å 64619 9uyn EMDB-64619, PDB-9uyn: Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to beta-arrestin 1 in ligand-free state 手法: EM (単粒子) / 解像度: 2.9 Å
化合物	ChemComp-Y01: CHOLESTEROL HEMISUCCINATE / コレステリルヘミスクシナ-ト ChemComp-PAM: PALMITOLEIC ACID / パルミトレイン酸
由来	homo sapiens (ヒト) escherichia phage ecszw-2 (ファージ)
キーワード	MEMBRANE PROTEIN/IMMUNE SYSTEM / G protein-coupled receptor 1 / chemerin / beta-arrestin1 / signaling protein / MEMBRANE PROTEIN-IMMUNE SYSTEM complex / beta-arrestin 2