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TitleGram-scale enzymatic synthesis of 2'-deoxyribonucleoside analogues using nucleoside transglycosylase-2.
Journal, issue, pagesChem Sci, Vol. 15, Page 15399-15407, Year 2024
Publish dateApr 12, 2024 (structure data deposition date)
AuthorsSalihovic, A. / Ascham, A. / Taladriz-Sender, A. / Bryson, S. / Withers, J.M. / McKean, I.J.W. / Hoskisson, P.A. / Grogan, G. / Burley, G.A.
External linksChem Sci / PubMed:39234214
MethodsX-ray diffraction
Resolution2.37 - 2.79 Å
Structure data

PDB-9ezk:
Nucleoside-2'-deoxyribosyltransferase from Lactobacillus leichmannii (apo).
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

PDB-9f08:
Nucleoside-2'-deoxyribosyltransferase from Lactobacillus leichmannii. Covalent complex with 2-deoxyribose.
Method: X-RAY DIFFRACTION / Resolution: 2.371 Å

PDB-9f09:
Nucleoside-2'-deoxyribosyltransferase from Lactobacillus leichmannii. Complex with 2-deoxyribose, 7-Bromo-1H-imidazo[4,5-b]pyridine and 2'-deoxycytidine
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-2DR:
2-deoxy-beta-D-erythro-pentofuranose

ChemComp-DCZ:
2'-DEOXYCYTIDINE

PDB-1h8p:
Bull seminal plasma PDC-109 fibronectin type II module

Source
  • lactobacillus leichmannii (bacteria)
KeywordsTRANSFERASE / Nucleoside-2'-deoxyribosyltransferase

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