Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice.
Journal, issue, pages	Nat Struct Mol Biol, Year 2024
Publish date	Sep 6, 2024
Authors	Martin Obr / Mathias Percipalle / Darya Chernikova / Huixin Yang / Andreas Thader / Gergely Pinke / Dario Porley / Louis M Mansky / Robert A Dick / Florian K M Schur /
PubMed Abstract	Human T cell leukemia virus type 1 (HTLV-1) immature particles differ in morphology from other retroviruses, suggesting a distinct way of assembly. Here we report the results of cryo-electron ...Human T cell leukemia virus type 1 (HTLV-1) immature particles differ in morphology from other retroviruses, suggesting a distinct way of assembly. Here we report the results of cryo-electron tomography studies of HTLV-1 virus-like particles assembled in vitro, as well as derived from cells. This work shows that HTLV-1 uses a distinct mechanism of Gag-Gag interactions to form the immature viral lattice. Analysis of high-resolution structural information from immature capsid (CA) tubular arrays reveals that the primary stabilizing component in HTLV-1 is the N-terminal domain of CA. Mutagenesis analysis supports this observation. This distinguishes HTLV-1 from other retroviruses, in which the stabilization is provided primarily by the C-terminal domain of CA. These results provide structural details of the quaternary arrangement of Gag for an immature deltaretrovirus and this helps explain why HTLV-1 particles are morphologically distinct.
External links	Nat Struct Mol Biol / PubMed:39242978
Methods	EM (subtomogram averaging) / EM (tomography)
Resolution	3.4 - 6.9 Å
Structure data	17929 8pu6 EMDB-17929, PDB-8pu6: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: pooled class Method: EM (subtomogram averaging) / Resolution: 3.4 Å 17930 8pu7 EMDB-17930, PDB-8pu7: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle -20 degrees Method: EM (subtomogram averaging) / Resolution: 4.8 Å 17931 8pu8 EMDB-17931, PDB-8pu8: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle -15 degrees Method: EM (subtomogram averaging) / Resolution: 4.0 Å 17932 8pu9 EMDB-17932, PDB-8pu9: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle -10 degrees Method: EM (subtomogram averaging) / Resolution: 3.7 Å 17933 8pua EMDB-17933, PDB-8pua: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle -05 degrees Method: EM (subtomogram averaging) / Resolution: 3.7 Å 17934 8pub EMDB-17934, PDB-8pub: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 0 degrees Method: EM (subtomogram averaging) / Resolution: 4.0 Å 17935 8puc EMDB-17935, PDB-8puc: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 05 degrees Method: EM (subtomogram averaging) / Resolution: 4.3 Å 17936 8pud EMDB-17936, PDB-8pud: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 10 degrees Method: EM (subtomogram averaging) / Resolution: 4.5 Å 17937 8pue EMDB-17937, PDB-8pue: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 15 degrees Method: EM (subtomogram averaging) / Resolution: 6.9 Å EMDB-17938: Cryo-electron tomogram of HTLV-1 MA126CANC tubes Method: EM (tomography) EMDB-17939: Cryo-electron tomogram of HTLV-1 MA126CANC tubes Method: EM (tomography) 17940 8puf EMDB-17940, PDB-8puf: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 20 degrees Method: EM (subtomogram averaging) / Resolution: 6.1 Å EMDB-17941: Cryo-electron tomogram containing HTLV-1 Gag-based VLPs Method: EM (tomography) 17942 8pug EMDB-17942, PDB-8pug: Structure of the immature HTLV-1 CA lattice from full-length Gag VLPs: CA-NTD refinement Method: EM (subtomogram averaging) / Resolution: 5.9 Å 17943 8puh EMDB-17943, PDB-8puh: Structure of the immature HTLV-1 CA lattice from full-length Gag VLPs: CA-CTD refinement Method: EM (subtomogram averaging) / Resolution: 6.2 Å
Source	human t-cell leukemia virus type i
Keywords	VIRAL PROTEIN / Retrovirus / HTLV / immature capsid / CA / CA-NTD