| タイトル | A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers. |
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| ジャーナル・号・ページ | Nat Commun, Vol. 14, Page 7956-7956, Year 2023 |
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| 掲載日 | 2023年2月16日 (構造データの登録日) |
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著者 | Wranik, M. / Kepa, M.W. / Beale, E.V. / James, D. / Bertrand, Q. / Weinert, T. / Furrer, A. / Glover, H. / Gashi, D. / Carrillo, M. ...Wranik, M. / Kepa, M.W. / Beale, E.V. / James, D. / Bertrand, Q. / Weinert, T. / Furrer, A. / Glover, H. / Gashi, D. / Carrillo, M. / Kondo, Y. / Stipp, R.T. / Khusainov, G. / Nass, K. / Ozerov, D. / Cirelli, C. / Johnson, P.J.M. / Dworkowski, F. / Beale, J.H. / Stubbs, S. / Zamofing, T. / Schneider, M. / Krauskopf, K. / Gao, L. / Thorn-Seshold, O. / Bostedt, C. / Bacellar, C. / Steinmetz, M.O. / Milne, C. / Standfuss, J. |
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リンク | Nat Commun / PubMed:38042952 |
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| 手法 | X線回折 |
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| 解像度 | 1.31 - 3.2 Å |
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| 構造データ | PDB-8cl5: Lysozyme in matrix of lipidic cubic phase of monoolein (LCP) 手法: X-RAY DIFFRACTION / 解像度: 1.31 Å PDB-8cl6: Lysozyme in matrix of hydroxyethylcellulose (HEC) 手法: X-RAY DIFFRACTION / 解像度: 1.32 Å PDB-8cl7: Krokinobacter eikastus rhodopsin 2 (KR2) in dark state 手法: X-RAY DIFFRACTION / 解像度: 1.76 Å PDB-8cl8: Krokinobacter eikastus rhodopsin 2 (KR2) extrapolated map 1us after light activation 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-8cl9: Tubulin-DARPin D1 complex 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-8clb: Colchicine bound to tubulin (T2R-TTL) complex 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-8clc: Tubulin (T2R-TTL) complex 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-8cld: Ansamitocin P3 bound to tubulin (T2R-TTL) complex 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-8cle: Vinblastine bound to tubulin (T2R-TTL) complex 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-8clf: Z-SolQ2Br bound to tubulin (T2R-TTL) complex 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-8clg: Epothilone A and Colchicine bound to tubulin (T2R-TTL) complex 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-8clh: Drug cocktail (Colchicine, Epothilone A, Peloruside, Ansamitocin P3, Vinblastine) bound to tubulin (T2R-TTL) complex 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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| 化合物 | ChemComp-GTP: GUANOSINE-5'-TRIPHOSPHATE / GTP, エネルギー貯蔵分子*YM
ChemComp-GDP: GUANOSINE-5'-DIPHOSPHATE / GDP, エネルギー貯蔵分子*YM
ChemComp-LOC: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide / 薬剤, 抗炎症剤*YM
ChemComp-ACP: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, エネルギー貯蔵分子類似体*YM
ChemComp-BKF: (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate
ChemComp-VLB: (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE / 薬剤, 化学療法薬*YM
ChemComp-V1O: 5-[[4-(2-bromoethyl)-3,5-dimethoxy-phenyl]diazenyl]-2-methoxy-phenol
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| 由来 | asplenium bulbiferum subsp. bulbiferum (植物) dokdonia eikasta (バクテリア)- synthetic construct (人工物)
 bos taurus (ウシ) mus musculus (ハツカネズミ) pavo cristatus (インドクジャク) rattus norvegicus (ドブネズミ) gallus gallus (ニワトリ)
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キーワード | HYDROLASE / lysozyme / lysozyme activity / catalytic activity / hydrolase activity / MEMBRANE PROTEIN / KR2 / Light driven sodium pump / Sodium Pump / Photoactivation / Photocycle / CELL CYCLE / Drug-tubulin-complex Cell cycle inhibition |
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