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Structure paper

TitleStructural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Journal, issue, pagesStructure, Vol. 27, Page 590-, Year 2019
Publish dateMar 13, 2018 (structure data deposition date)
AuthorsTeyra, J. / Singer, A.U. / Schmitges, F.W. / Jaynes, P. / Kit Leng Lui, S. / Polyak, M.J. / Fodil, N. / Krieger, J.R. / Tong, J. / Schwerdtfeger, C. ...Teyra, J. / Singer, A.U. / Schmitges, F.W. / Jaynes, P. / Kit Leng Lui, S. / Polyak, M.J. / Fodil, N. / Krieger, J.R. / Tong, J. / Schwerdtfeger, C. / Brasher, B.B. / Ceccarelli, D.F.J. / Moffat, J. / Sicheri, F. / Moran, M.F. / Gros, P. / Eichhorn, P.J.A. / Lenter, M. / Boehmelt, G. / Sidhu, S.S.
External linksStructure / PubMed:30713027
MethodsX-ray diffraction
Resolution1.9 - 3.1 Å
Structure data

PDB-6cpm:
Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv
Method: X-RAY DIFFRACTION / Resolution: 2.011 Å

PDB-6crn:
Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6dj9:
Structure of the USP15 DUSP domain in complex with a high-affinity Ubiquitin Variant (UbV)
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-6ml1:
Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory Ubv
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
  • escherichia coli (E. coli)
KeywordsSIGNALING PROTEIN / deubiuqitination / Ubv / high-affinity / inhibition / deubiquitination / strand-exchange / dimerization

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