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Structure paper

TitleStructures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page E4630-E4638, Year 2016
Publish dateNov 27, 2015 (structure data deposition date)
AuthorsCaputo, A.T. / Alonzi, D.S. / Marti, L. / Reca, I.B. / Kiappes, J.L. / Struwe, W.B. / Cross, A. / Basu, S. / Lowe, E.D. / Darlot, B. ...Caputo, A.T. / Alonzi, D.S. / Marti, L. / Reca, I.B. / Kiappes, J.L. / Struwe, W.B. / Cross, A. / Basu, S. / Lowe, E.D. / Darlot, B. / Santino, A. / Roversi, P. / Zitzmann, N.
External linksProc. Natl. Acad. Sci. USA / PubMed:27462106
MethodsX-ray diffraction
Resolution1.74 - 2.4 Å
Structure data

PDB-5f0e:
Murine endoplasmic reticulum alpha-glucosidase II
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

PDB-5h9o:
Complex of Murine endoplasmic reticulum alpha-glucosidase II with D-Glucose
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

PDB-5hjo:
Murine endoplasmic reticulum alpha-glucosidase II with bound substrate analogue
Method: X-RAY DIFFRACTION / Resolution: 2.29 Å

PDB-5hjr:
Murine endoplasmic reticulum alpha-glucosidase II with bound covalent intermediate
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-5ied:
Murine endoplasmic reticulum alpha-glucosidase II with castanospermine
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

PDB-5iee:
Murine endoplasmic reticulum alpha-glucosidase II with 1-deoxynojirimycin
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

PDB-5ief:
Murine endoplasmic reticulum alpha-glucosidase II with N-butyl-1-deoxynojirimycin
Method: X-RAY DIFFRACTION / Resolution: 2.38 Å

PDB-5ieg:
Murine endoplasmic reticulum alpha-glucosidase II with N-9'-methoxynonyl-1-deoxynojirimycin.
Method: X-RAY DIFFRACTION / Resolution: 1.822 Å

Chemicals

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-FMT:
FORMIC ACID

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-OXM:
OXAMIC ACID

ChemComp-GLC:
alpha-D-glucopyranose

ChemComp-TAR:
D(-)-TARTARIC ACID

ChemComp-ACT:
ACETATE ION

ChemComp-DGO:
D-glucal

ChemComp-5GF:
5-fluoro-beta-D-glucopyranose

ChemComp-CTS:
CASTANOSPERMINE

ChemComp-NOJ:
1-DEOXYNOJIRIMYCIN

ChemComp-NBV:
(2R,3R,4R,5S)-1-BUTYL-2-(HYDROXYMETHYL)PIPERIDINE-3,4,5-TRIOL

ChemComp-6A9:
N-9'-methoxynonyl-1-deoxynojirimycin

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / Enzyme Glycosyl hydrolase GH31 Quality control exoglycosidase / Enzyme Glycosyl hydrolase / GH31 / Quality control exoglycosidase / DNJ / NB-DNJ / MON-DNJ

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