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Structure paper

TitleProbing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 112, Page 8596-8601, Year 2015
Publish dateJun 19, 2015 (structure data deposition date)
AuthorsSohl, C.D. / Szymanski, M.R. / Mislak, A.C. / Shumate, C.K. / Amiralaei, S. / Schinazi, R.F. / Anderson, K.S. / Yin, Y.W.
External linksProc. Natl. Acad. Sci. USA / PubMed:26124101
MethodsX-ray diffraction
Resolution3.426 - 3.637 Å
Structure data

PDB-5c51:
Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma
Method: X-RAY DIFFRACTION / Resolution: 3.426 Å

PDB-5c52:
Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma
Method: X-RAY DIFFRACTION / Resolution: 3.637 Å

PDB-5c53:
Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma
Method: X-RAY DIFFRACTION / Resolution: 3.567 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-1RY:
[[(2R,5S)-5-(4-azanyl-5-fluoranyl-2-oxidanylidene-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate

ChemComp-4Y3:
[[(2S,5R)-5-(4-azanyl-5-fluoranyl-2-oxidanylidene-pyrimidin-1-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate

ChemComp-DOC:
2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE

Source
  • homo sapiens (human)
  • virus chimp162
  • dna launch vector pde-gfp2 (others)
Keywordstransferase/dna / Nucleoside reverse transcriptase inhibitors (NRTIs) / HIV RT / human mitochondrial DNA polymerase / mitochondrial toxicity / drug efficacy and toxicity / transferase-dna complex / HIV reverse transcriptase (RT) / TRANSFERASE

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