EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural Basis for the Recognition of Mycolic Acid Precursors by Kasa, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis
ジャーナル・号・ページ	J. Biol. Chem., Vol. 288, Page 34190-, Year 2013
掲載日	2013年9月19日 (構造データの登録日)
著者	Schiebel, J. / Kapilashrami, K. / Fekete, A. / Bommineni, G.R. / Schaefer, C.M. / Mueller, M.J. / Tonge, P.J. / Kisker, C.
リンク	J. Biol. Chem. / PubMed:24108128
手法	X線回折
解像度	1.5 - 2.7 Å
構造データ	PDB-4c6u: Crystal structure of M. tuberculosis KasA in complex with TLM5 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4c6v: Crystal structure of M. tuberculosis KasA in complex with TLM5 (Soak for 5 min) 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-4c6w: Crystal structure of M. tuberculosis C171Q KasA 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4c6x: Crystal structure of M. tuberculosis C171Q KasA in complex with thiolactomycin (TLM) 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-4c6z: Crystal structure of M. tuberculosis C171Q KasA in complex with TLM3 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4c70: Crystal structure of M. tuberculosis C171Q KasA in complex with TLM4 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-4c71: Crystal structure of M. tuberculosis C171Q KasA in complex with TLM18 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4c72: Crystal structure of M. tuberculosis C171Q KasA in complex with TLM5 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-4c73: Crystal structure of M. tuberculosis C171Q KasA in complex with TLM6 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å
化合物	ChemComp-EDO: 1,2-ETHANEDIOL ChemComp-CL: Unknown entry ChemComp-K: Unknown entry ChemComp-TLG: (5R)-3-acetyl-4-hydroxy-5-methyl-5-[(1Z)-2-methylbuta-1,3-dien-1-yl]thiophen-2(5H)-one ChemComp-HOH: WATER ChemComp-M7U: (2R)-2-(hexadecanoyloxy)-3-{[(10R)-10-methyloctadecanoyl]oxy}propyl phosphate ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH緩衝剤YM ChemComp-PEG: DI(HYDROXYETHYL)ETHER ChemComp-NA: Unknown entry ChemComp-TLM: THIOLACTOMYCIN ChemComp-TLE: (5R)-3-ethyl-4-hydroxy-5-methyl-5-[(1E)-2-methylbuta-1,3-dien-1-yl]thiophen-2(5H)-one ChemComp-GOL: GLYCEROL ChemComp-IPA: ISOPROPYL ALCOHOL ChemComp-TLJ: (5R)-4-hydroxy-5-methyl-5-[(1E)-2-methylbuta-1,3-dien-1-yl]-3-propylthiophen-2(5H)-one ChemComp-FMT: FORMIC ACID ChemComp-7RD: (R,E)-3-(4-AZIDOBUTYL)-4-HYDROXY-5-METHYL-5-(2-METHYLBUTA-1,3-DIEN-1-YL)THIOPHEN-2(5H)-ONE ChemComp-TLH*: (5R)-5-methyl-5-[(1E)-2-methylbuta-1,3-dienyl]-4-oxidanyl-3-[2,2,2-tris(fluoranyl)ethanoyl]thiophen-2-one
由来	mycobacterium tuberculosis (結核菌) mycobacterium tuberculosis h37rv (結核菌)
キーワード	TRANSFERASE / KAS ENZYME / TYPE 2 FATTY ACID BIOSYNTHESIS / MYCOLIC ACID SYNTHESIS / THIOLACTOMYCIN / CONDENSING ENZYME / KASA / BETO-KETOACYL-ACP SYNTHASE