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| Title | Cryo-EM insights into isoform-specific properties of the IP3R2 channel |
|---|---|
| Journal, issue, pages | Nat Commun, Year 2026 |
| Publish date | Mar 22, 2026 (structure data deposition date) |
Authors | Baker MR / Lin X / Fan G / Martinez-Chavez A / Wagner LE / Malik S / Allison T / Bell B / Seryshev AB / Cordero-Morales J ...Baker MR / Lin X / Fan G / Martinez-Chavez A / Wagner LE / Malik S / Allison T / Bell B / Seryshev AB / Cordero-Morales J / Baker ML / Yule DI / Serysheva II |
External links | Nat Commun / Search PubMed |
| Methods | EM (single particle) |
| Resolution | 2.95 - 3.64 Å |
| Structure data | ![]() EMDB-76249: Apo-IP3R2 Local Refinement of Ligand Binding Domains ![]() EMDB-76250: Apo-IP3R2 Local Refinement of ARM1-HD Domains ![]() EMDB-76251: Apo-IP3R2 Local Refinement of ARM2 Domain ![]() EMDB-76252: Apo-IP3R2 Local Refinement of ARM3-ILD-LNK domains ![]() EMDB-76253: Apo-IP3R2 Local Refinement of TM domains ![]() EMDB-76254: IP3R2 (+IP3/Ca2+/ATP) Local Refinement of Ligand Binding Domains ![]() EMDB-76255: IP3R2 (+IP3/Ca2+/ATP) Local Refinement of ARM1-HD domains ![]() EMDB-76256: IP3R2 (+IP3/Ca2+/ATP) Local Refinement of TM domains ![]() EMDB-76257: IP3R2 (+IP3/Ca2+/ATP) Local Refinement of ARM2 domains ![]() EMDB-76258: IP3R2 (+IP3/Ca2+/ATP) Local Refinement of ARM3-ILD-LNK domains ![]() EMDB-76259: Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptors (IP3R2) in the Apo-state (composite map) EMDB-76260, PDB-12ad: ![]() EMDB-76262: Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptor (IP3R2)in the presence of IP3/Ca2+/ATP (Composite map) EMDB-76264, PDB-12ai: |
| Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-PLX: ![]() ChemComp-ATP: ![]() ChemComp-I3P: ![]() ChemComp-CA: |
| Source |
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Keywords | MEMBRANE PROTEIN / ion channel |
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