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TitleStructural origins of species-specific differences in TRPV2 activation.
Journal, issue, pagesNat Commun, Vol. 17, Issue 1, Year 2026
Publish dateAug 20, 2026
AuthorsTabea C Fricke / Ruth A Pumroy / Julia A Rocereta / José J De Jesús-Pérez / George Oprita / Marvin J A Meyer / Christine Herzog / Frank G Echtermeyer / Kerstin Hill / Andreas Leffler / Vera Y Moiseenkova-Bell /
PubMed AbstractTransient receptor potential vanilloid 2 (TRPV2) is a broadly expressed ion channel implicated in diverse physiological and pathological processes. Despite strong conservation, human TRPV2 (hTRPV2) ...Transient receptor potential vanilloid 2 (TRPV2) is a broadly expressed ion channel implicated in diverse physiological and pathological processes. Despite strong conservation, human TRPV2 (hTRPV2) displays markedly reduced sensitivity to stimuli such as 2-aminoethoxydiphenyl borate (2-APB) and heat compared to rodent orthologs. Here we combine electrophysiology and cryo electron microscopy to define the basis of this species-dependent divergence. The structure of hTRPV2 is remarkably different at the voltage sensor-like domain (VSLD) compared to rodent channels and functional analyses show a graded activity profile between human, mouse and rat TRPV2 to a broad range of chemical and physical stimuli. Three residues located between S6 and the TRP domain tune this functional difference, as reciprocal substitutions exchange current phenotypes. hTRPV2 structures of this mutant reveal coupling between the mutation site and the VSLD as well as an additional binding site for 2-APB. Together, these findings define structural determinants of species-specific TRPV2 function.
External linksNat Commun / PubMed:42624855 / PubMed Central
MethodsEM (single particle)
Resolution2.76 - 3.36 Å
Structure data

75707

11hz

EMDB-75707, PDB-11hz:
Apo human TRPV2, wild-type
Method: EM (single particle) / Resolution: 3.36 Å

75708

11ia

EMDB-75708, PDB-11ia:
Apo human TRPV2, S651H/T654D/D655N
Method: EM (single particle) / Resolution: 2.76 Å

75709

11ib

EMDB-75709, PDB-11ib:
2-APB bound human TRPV2, S651H/T654D/D655N
Method: EM (single particle) / Resolution: 3.33 Å

75711

11id

EMDB-75711, PDB-11id:
apo rat TRPV2, H651S/D654T/N655D
Method: EM (single particle) / Resolution: 2.95 Å

75712

11ie

EMDB-75712, PDB-11ie:
2-APB bound rat TRPV2, H651S/D654T/N655D
Method: EM (single particle) / Resolution: 3.07 Å

Chemicals

ChemComp-CLR:
CHOLESTEROL

ChemComp-PEX:
1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

ChemComp-FZ4:
2-aminoethyl diphenylborinate

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN / TRPV2 / ion channel / TRP channel / 2-APB

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