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TitleDegron-independent recruitment of KAT2A expands the target space of CRBN molecular glues.
Journal, issue, pagesScience, Vol. 393, Issue 6807, Page 188-194, Year 2026
Publish dateJul 9, 2026
AuthorsSamuel Ojeda / Meng Wang / Kheewoong Baek / Wallace Bourgeois / Alba Sommerschield / Hong Yue / Rebecca J Metivier / Panos Karagiannis / Talya S Levitz / Yuan Xiong / Katherine A Donovan / Scott A Armstrong / Eric S Fischer /
PubMed AbstractLysine acetyltransferases (KATs) cooperate with oncogenes such as c-Myc, estrogen receptor, and lysine methyltransferase 2A (KMT2A) fusions to sustain malignant programs. Targeting of KAT proteins ...Lysine acetyltransferases (KATs) cooperate with oncogenes such as c-Myc, estrogen receptor, and lysine methyltransferase 2A (KMT2A) fusions to sustain malignant programs. Targeting of KAT proteins has shown clinical efficacy; however, achieving homolog selectivity for most KATs remains a major challenge. By extending cereblon (CRBN)-based molecular glues beyond the canonical degron space, we developed an exquisitely selective degrader of KAT2A. Cryo-electron microscopy revealed that CRBN recruits KAT2A independently of a degron; instead, the molecular glue engages a surface-exposed tyrosine, mimicking antibody-like molecular recognition. Selective KAT2A degradation leads to potent ablation of histone H3 lysine 9 acetylation (H3K9Ac), antiproliferative effects in acute myeloid leukemia cell lines, and in vivo efficacy in a patient-derived xenograft model, establishing KAT2A as a targetable vulnerability to treat a wide range of malignancies. More generally, degron-independent recruitment extends the CRBN-targetable proteome.
External linksScience / PubMed:42424456 / PubMed Central
MethodsEM (single particle)
Resolution2.9 Å
Structure data

75101

10dw

EMDB-75101, PDB-10dw:
Structure of CRBN/DDB1dB-KAT2A-Compound4 ternary complex
Method: EM (single particle) / Resolution: 2.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

PDB-1c5c:
DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CRBN / molecular glue / CRBN-MG / KAT2A

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