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TitleStructures of naked mole-rat, tuco-tuco, and guinea pig ribosomes-is rRNA fragmentation linked to translational fidelity?
Journal, issue, pagesNucleic Acids Res, Vol. 54, Issue 3, Year 2026
Publish dateJan 22, 2026
AuthorsCristina Gutierrez-Vargas / Swastik De / Suvrajit Maji / Zheng Liu / Zhonghe Ke / Martina Nieß / Andrei Seluanov / Vera Gorbunova / Joachim Frank /
PubMed AbstractRibosomes are central to protein synthesis in all organisms. In mammals, the ribosome functional core is highly conserved. Remarkably, two rodent species, the naked mole-rat (NMR) and tuco-tuco, ...Ribosomes are central to protein synthesis in all organisms. In mammals, the ribosome functional core is highly conserved. Remarkably, two rodent species, the naked mole-rat (NMR) and tuco-tuco, display fragmented 28S ribosomal RNA (rRNA), coupled with high translational fidelity and long lifespan. The unusual ribosomal architecture in the NMR and tuco-tuco has been speculated to be linked to high translational fidelity. Here, we show, by single-particle cryo-electron microscopy, that despite the fragmentation of their rRNA, NMR and tuco-tuco ribosomes retain their core functional architecture. Compared to ribosomes of the guinea pig, a phylogenetically related rodent without 28S rRNA fragmentation, ribosomes of NMR and tuco-tuco exhibit poorly resolved density for certain expansion segments. In contrast, the structure of the guinea pig ribosome shows high similarity to the human ribosome. Enhanced translational fidelity in the NMR and tuco-tuco may stem from subtle, allosteric effects in dynamics, linked to rRNA fragmentation.
External linksNucleic Acids Res / PubMed:41603730 / PubMed Central
MethodsEM (single particle)
Resolution3.1 - 5.0 Å
Structure data

72469

9y42

EMDB-72469, PDB-9y42:
Structure of naked mole-rat ribosome with P/E tRNA and eEF2 (rotated)
Method: EM (single particle) / Resolution: 5.0 Å

72470

9y44

EMDB-72470, PDB-9y44:
Structure of naked mole-rat ribosome (rotated, tRNAs, and mRNA)
Method: EM (single particle) / Resolution: 4.9 Å

72475

9y49

EMDB-72475, PDB-9y49:
Structure of tuco-tuco ribosome with P/E tRNA and eEF2 (rotated)
Method: EM (single particle) / Resolution: 3.4 Å

72482

9y4g

EMDB-72482, PDB-9y4g:
Structure of tuco-tuco ribosome (rotated, tRNAs, and mRNA)
Method: EM (single particle) / Resolution: 3.3 Å

72483

9y4h

EMDB-72483, PDB-9y4h:
Structure of guinea pig ribosome with P/E-tRNA and mRNA
Method: EM (single particle) / Resolution: 4.7 Å

74615

9zrg

EMDB-74615, PDB-9zrg:
Structure of naked mole-rat ribosome (non-rotated)
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • heterocephalus glaber (naked mole-rat)
  • ctenomyidae (tuco-tucos)
  • cavia porcellus (domestic guinea pig)
KeywordsRIBOSOME / Naked mole rat ribosome / Tuco tuco ribosome / Guinea pig ribosome

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