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TitleCryo-EM structure of pro-aggregant P301L/S320F double-mutant tau filaments formed in mouse brains following peripheral AAV delivery
Journal, issue, pagesBiorxiv, Year 2026
Publish dateJan 14, 2026 (structure data deposition date)
AuthorsKano M / Kimura T / Yanagisawa H / Tatsumi L / Yamashita K / Sakai A / Li X / Saido TC / Saito T / Takatori S ...Kano M / Kimura T / Yanagisawa H / Tatsumi L / Yamashita K / Sakai A / Li X / Saido TC / Saito T / Takatori S / Kikkawa M / Tomita T
External linksBiorxiv / Search PubMed
MethodsEM (single particle)
Resolution2.2 Å
Structure data

68389

22jy

EMDB-68389, PDB-22jy:
P301L/S320F human tau filaments from mouse brain
Method: EM (single particle) / Resolution: 2.2 Å

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / Amyloid Fibril / Alzheimer disease / Pick disease tau / tauopathy

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