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Keywords
Structure methods
Author
Journal
IF

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Structure paper

Titlestructural basis for inhibition of mammalian respirasome by metformin and proguanil
Journal, issue, pagesTo Be Published
Publish dateMay 29, 2024 (structure data deposition date)
AuthorsTeng F / He ZX / Yang YQ / Guo RY / Hu YQ / Xu CY / Zhou RH / Zhang X / Zhang S / Zhou L
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.97 - 3.1 Å
Structure data

60329

8zp8

EMDB-60329, PDB-8zp8:
Respirasome open state 1 in presence of metformin(SC-MetO1)
Method: EM (single particle) / Resolution: 2.97 Å

60425

8zsr

EMDB-60425, PDB-8zsr:
Complex I form respirasome open state bound by proguanil (SC-ProgO)
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-CDL:
CARDIOLIPIN / phospholipid*YM

ChemComp-ZN:
Unknown entry

ChemComp-PC1:
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE / phospholipid*YM

ChemComp-PEE:
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine / DOPE, phospholipid*YM

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-ZMP:
S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-PLX:
(9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL / phospholipid*YM

ChemComp-3PE:
1,2-Distearoyl-sn-glycerophosphoethanolamine / phospholipid*YM

ChemComp-HEA:
HEME-A

ChemComp-CU:
COPPER (II) ION

ChemComp-MG:
Unknown entry

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-HEC:
HEME C

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-XEW:
N-(4-chlorophenyl)-N'-(propan-2-yl)triimidodicarbonic diamide / medication*YM

Source
  • sus scrofa (pig)
KeywordsMEMBRANE PROTEIN / Metformin / electron transport chain / Respirasome / mammalia

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