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TitleStructural Basis for Inhibition of Mammalian Respirasome by Metformin and Proguanil
Journal, issue, pagesTo Be Published
Publish dateMay 28, 2024 (structure data deposition date)
AuthorsTeng F / He ZX / Yang YQ / Guo RY / Hu YQ / Xu CY / Zhou RH / Zhang X / Zhang S / Zhou L
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.85 - 3.63 Å
Structure data

EMDB-60300: Cryo-EM map of respirasome open state 1 in presence of metformin (SC-MetO1)
Method: EM (single particle) / Resolution: 3.09 Å

EMDB-60301: Cryo-EM map of respirasome open state 1 in presence of metformin (SC-MetO1), complex I peripheral arm focused
Method: EM (single particle) / Resolution: 2.97 Å

EMDB-60302: Cryo-EM map of respirasome open state 1 in presence of metformin (SC-MetO1), complex I proximal membrane arm focused
Method: EM (single particle) / Resolution: 2.99 Å

EMDB-60303: Cryo-EM map of respirasome open state 1 in presence of metformin (SC-MetO1), complex I distal membrane arm focused
Method: EM (single particle) / Resolution: 2.93 Å

EMDB-60304: Cryo-EM map of respirasome open state 1 in presence of metformin (SC-MetO1), complex III2 focused
Method: EM (single particle) / Resolution: 3.03 Å

EMDB-60305: Cryo-EM map of respirasome open state 1 in presence of metformin (SC-MetO1), complex IV focused
Method: EM (single particle) / Resolution: 3.63 Å

EMDB-60371: Cryo-EM map of respirasome open state bound by proguanil (SC-ProgO)
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-60372: Cryo-EM map of respirasome open state bound by proguanil (SC-ProgO), complex I peripheral arm focused
Method: EM (single particle) / Resolution: 2.86 Å

EMDB-60373: Cryo-EM map of respirasome open state bound by proguanil (SC-ProgO), complex I proximal membrane arm focused
Method: EM (single particle) / Resolution: 3.01 Å

EMDB-60374: Cryo-EM map of respirasome open state bound by proguanil (SC-ProgO), complex I distal membrane arm focused
Method: EM (single particle) / Resolution: 2.85 Å

Source
  • Sus scrofa (pig)

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