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-Structure paper
Title | mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Year 2024 |
Publish date | Apr 26, 2024 (structure data deposition date) |
![]() | Battaglioni S / Craigie LM / Filippini S / Maier T / Hall MN |
![]() | Search PubMed |
Methods | EM (single particle) |
Resolution | 3.27 - 4.02 Å |
Structure data | EMDB-50181, PDB-9f42: EMDB-50182, PDB-9f43: EMDB-50183, PDB-9f44: EMDB-50184, PDB-9f45: ![]()
EMDB-50253: cryo-EM structure of human LST2 bound to human mTOR complex 1 ![]()
EMDB-50254: Cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on one protomer ![]()
EMDB-50255: Cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on one protomer |
Chemicals | ![]() ChemComp-IHP: |
Source |
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![]() | SIGNALING PROTEIN / MTOR / MTORC1 / LST2 / ZFYVE28 / EGFR / TOS |