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TitleStructure and dynamics of PARP1-HPF1 engaging nicked DNA suggests a mechanism for acute production of localized ADP-ribose modifications
Journal, issue, pagesTo Be Published
Publish dateDec 14, 2024 (structure data deposition date)
AuthorsSverzhinsky A / Xue H / Langelier M-F / Del Mundo J / Classen S / Hammel M / Rothenberg E / Pascal JM
External linksSearch PubMed
MethodsEM (single particle)
Resolution4.3 Å
Structure data

48313

9mja

EMDB-48313, PDB-9mja:
PARP1 ART in complex with HPF1 and EB47
Method: EM (single particle) / Resolution: 4.3 Å

Chemicals

ChemComp-UHB:
2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / PARP1 / Zinc-finger domains / nicked DNA

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