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TitleStructural basis of ligand-gating, allosteric modulation, and channel blockade in human GluN1a-2B-2D tri-heteromeric NMDA receptor
Journal, issue, pagesTo Be Published
Publish dateAug 9, 2024 (structure data deposition date)
AuthorsHyunook K / Max E / Tue GB / Riley EP / Noriko S / Stephen FT / Hiro F
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.28 - 6.07 Å
Structure data

EMDB-46509: Consensus map of open state GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.95 Å

EMDB-46510: TMD local refined map of open state GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 4.44 Å

EMDB-46511: ECD local refined map of open state GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.83 Å

EMDB-46513: Consensus map of Gly-,PPDA bound GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.65 Å

EMDB-46514: ECD local refined map of Gly-,PPDA bound GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.59 Å

EMDB-46515: TMD local refined map of Gly-,PPDA bound GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.52 Å

EMDB-46516: Consensus map of nonactive state GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.34 Å

EMDB-46517: TMD local refined map of non-active state GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.85 Å

EMDB-46518: ECD local refined map of nonactive state GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.28 Å

EMDB-46519: Consensus map of Gly-,Glu-,(S)-DQP-997-74 bound GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.71 Å

EMDB-46520: TMD local refined map of Gly-,Glu-,(S)-DQP-997-74 bound NMDAR
Method: EM (single particle) / Resolution: 6.07 Å

EMDB-46521: ECD local refined map of Gly-,Glu-,(S)-DQP-997-74 bound NMDAR
Method: EM (single particle) / Resolution: 3.7 Å

EMDB-46522: Consensus map of Gly-,Glu-,(S)-(+)-ketamine bound GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.96 Å

EMDB-46523: TMD local refined map of Gly-,Glu-,(S)-(+)-ketamine bound GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 4.33 Å

EMDB-46524: ECD local refined map of Gly-,Glu-,(S)-(+)-ketamine bound GluN1a-2B-2D NMDAR
Method: EM (single particle) / Resolution: 3.93 Å

Source
  • Homo sapiens (human)

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