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TitleIn situ architecture of the human prohibitin complex.
Journal, issue, pagesNat Cell Biol, Vol. 27, Issue 4, Page 633-640, Year 2025
Publish dateMar 21, 2025
AuthorsFelix Lange / Michael Ratz / Jan-Niklas Dohrke / Maxence Le Vasseur / Dirk Wenzel / Peter Ilgen / Dietmar Riedel / Stefan Jakobs /
PubMed AbstractProhibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, ...Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others. The human prohibitins prohibitin 1 and prohibitin 2 have been proposed to act as scaffolds within the mitochondrial inner membrane, but their molecular organization has remained elusive. Here we determined the molecular organization of the human prohibitin complex within the mitochondrial inner membrane using an integrative structural biology approach combining quantitative western blotting, cryo-electron tomography, subtomogram averaging and molecular modelling. The proposed bell-shaped structure consists of 11 alternating prohibitin 1 and prohibitin 2 molecules. This study reveals an average of about 43 prohibitin complexes per crista, covering 1-3% of the crista membrane area. These findings provide a structural basis for understanding the functional contributions of prohibitins to the integrity and spatial organization of the mitochondrial inner membrane.
External linksNat Cell Biol / PubMed:40119201 / PubMed Central
MethodsEM (subtomogram averaging)
Resolution16.3 Å
Structure data

19459

8rrh

EMDB-19459, PDB-8rrh:
The human prohibitin complex
Method: EM (subtomogram averaging) / Resolution: 16.3 Å

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Chaperone / Lipid organization / Protease regulator

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