EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Cryo-EM Reveals How Cardiomyopathy Therapeutic Drugs Modulate the Myosin Motors of the Heart
ジャーナル・号・ページ	To Be Published
掲載日	2025年10月13日 (構造データの登録日)
著者	Somavarapu AK / Ge J / Yengo CM / Craig R / Padron R
リンク	PubMedで検索
手法	EM (単粒子)
解像度	3.0 - 4.5 Å
構造データ	73268 9yop EMDB-73268, PDB-9yop: Cryo-EM structure of human beta-cardiac myosin in the interacting-heads motif and S2-FH docked state 手法: EM (単粒子) / 解像度: 3.5 Å 73283 9yp4 EMDB-73283, PDB-9yp4: Cryo-EM structure of human beta-cardiac myosin bound to omecamtiv mecarbil in the interacting-heads motif and S2-FH docked state 手法: EM (単粒子) / 解像度: 4.5 Å 73288 9yp9 EMDB-73288, PDB-9yp9: Cryo-EM structure of human beta-cardiac myosin bound to mavacamten in the interacting-heads motif and S2-FH docked state 手法: EM (単粒子) / 解像度: 3.0 Å 73362 9yr7 EMDB-73362, PDB-9yr7: Cryo-EM structure of human beta-cardiac myosin bound to mavacamten in the interacting-heads motif and S2-FH undocked state 手法: EM (単粒子) / 解像度: 3.0 Å 73367 9yrg EMDB-73367, PDB-9yrg: Cryo-EM structure of human beta-cardiac myosin in the interacting-heads motif and S2-FH undocked state 手法: EM (単粒子) / 解像度: 3.2 Å 73368 9yrh EMDB-73368, PDB-9yrh: Cryo-EM structure of human beta-cardiac myosin bound to omecamtiv mecarbil in the interacting-heads motif and S2-FH undocked state 手法: EM (単粒子) / 解像度: 3.8 Å
化合物	ChemComp-ADP: ADENOSINE-5'-DIPHOSPHATE / ADP, エネルギー貯蔵分子YM ChemComp-PO4: PHOSPHATE ION ChemComp-2OW: methyl 4-(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}benzyl)piperazine-1-carboxylate ChemComp-XB2: 6-[[(1~{S})-1-phenylethyl]amino]-3-propan-2-yl-1~{H}-pyrimidine-2,4-dione / 薬剤, 阻害剤YM
由来	homo sapiens (ヒト) mus musculus (ハツカネズミ) aequorea victoria (オワンクラゲ) saccharomyces cerevisiae (パン酵母)
キーワード	CONTRACTILE PROTEIN / Cardiac Myosin / Interacting Heads Motif / Actin Binding / Omecamtiv Mecarbil / Mavacamten