![](img/lk-miru.gif)
+
Open data
-
Basic information
Entry | ![]() | ||
---|---|---|---|
Name | Name: Synonyms: omecamtiv mercarbil Wikipedia | ![]()
Omecamtiv mecarbil (INN), previously referred to as CK-1827452, is a cardiac-specific myosin activator. It is an experimental drug being studied for a potential role in the treatment of left ventricular systolic heart failure. Systolic heart failure involves a loss of effective actin-myosin cross bridges in the myocytes (heart muscle cells) of the left ventricle, which leads to a decreased ability of the heart to move blood through the body... |
-Chemical information
Composition | |||||||||
---|---|---|---|---|---|---|---|---|---|
Others | Type: NON-POLYMER / PDB classification: HETAIN / Three letter code: 2OW / Ideal coordinates details: Corina / Model coordinates PDB-ID: 4PA0 | ||||||||
History |
| ||||||||
![]() | ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
-
Structure visualization
Structure viewer | Molecule: ![]() ![]() |
---|
-Details
-SMILES
ACDLabs 12.01 | CACTVS 3.385 | OpenEye OEToolkits 1.9.2 | |
---|
-SMILES CANONICAL
CACTVS 3.385 | OpenEye OEToolkits 1.9.2 | |
---|
-InChI
InChI 1.03 |
---|
-InChIKey
InChI 1.03 |
---|
-SYSTEMATIC NAME
ACDLabs 12.01 | OpenEye OEToolkits 1.9.2 | |
---|
-PDB entries
Showing all 3 items
![](data/pdb/img/4pa0.jpg)
PDB-4pa0:
Omecamtiv Mercarbil binding site on the Human Beta-Cardiac Myosin Motor Domain
![](data/pdb/img/5n69.jpg)
PDB-5n69:
Cardiac muscle myosin S1 fragment in the pre-powerstroke state co-crystallized with the activator Omecamtiv Mecarbil
![](data/pdb/img/8qyu.jpg)
PDB-8qyu:
Beta-cardiac myosin S1 fragment in the pre-powerstroke state complexed to Omecamtiv mecarbil