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Structure paper

TitleStructural basis for drug-induced allosteric changes to human beta-cardiac myosin motor activity.
Journal, issue, pagesNat Commun, Vol. 6, Page 7974-7974, Year 2015
Publish dateApr 6, 2014 (structure data deposition date)
AuthorsWinkelmann, D.A. / Forgacs, E. / Miller, M.T. / Stock, A.M.
External linksNat Commun / PubMed:26246073
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-4pa0:
Omecamtiv Mercarbil binding site on the Human Beta-Cardiac Myosin Motor Domain
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-2OW:
methyl 4-(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}benzyl)piperazine-1-carboxylate

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • aequorea victoria (jellyfish)
KeywordsMotor/Fluorescent Protein / Cardiac / Myosin / Motor / omecamtiv mercarbil / Motor-Fluorescent Protein complex

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