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-Structure paper
| タイトル | Cryo-EM structure of the human Pannexin-3 channel. |
|---|---|
| ジャーナル・号・ページ | Biochem Biophys Res Commun, Vol. 745, Page 151227, Year 2025 |
| 掲載日 | 2024年12月20日 |
著者 | Taiichi Tsuyama / Ryuga Teramura / Kaoru Mitsuoka / Jun-Ichi Kishikawa / Ken Yokoyama / ![]() |
| PubMed 要旨 | Pannexin-3 (PANX3) is a member of the pannexin family of large-pore, ATP-permeable channels conserved across vertebrates. PANX3 contributes to various developmental and pathophysiological processes ...Pannexin-3 (PANX3) is a member of the pannexin family of large-pore, ATP-permeable channels conserved across vertebrates. PANX3 contributes to various developmental and pathophysiological processes by permeating ATP and Ca ions; however, the structural basis of PANX3 channel function remains unclear. Here, we present the cryo-EM structure of human PANX3 at 2.9-3.2 Å. The PANX3 channel is heptameric and forms a transmembrane pore along the central symmetric axis. The narrowest constriction of the pore is composed of an isoleucine ring located in the extracellular region, and its size is comparable to that of other pannexins. A structural variability analysis revealed prominent structural dynamics in intracellular regions. Our structural studies provide a foundation for understanding the detailed properties of pannexin channels. |
リンク | Biochem Biophys Res Commun / PubMed:39721314 |
| 手法 | EM (単粒子) |
| 解像度 | 2.9 - 3.2 Å |
| 構造データ | EMDB-62478, PDB-9kom: EMDB-62526, PDB-9krg: |
| 由来 |
|
キーワード | TRANSPORT PROTEIN / Pannexin / Innexin |
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homo sapiens (ヒト)
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