タイトル | Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. |
---|
ジャーナル・号・ページ | Nat Commun, Vol. 15, Page 3785-3785, Year 2024 |
---|
掲載日 | 2023年12月31日 (構造データの登録日) |
---|
著者 | Mealka, M. / Sierra, N.A. / Avellaneda Matteo, D. / Albekioni, E. / Khoury, R. / Mai, T. / Conley, B.M. / Coleman, N.J. / Sabo, K.A. / Komives, E.A. ...Mealka, M. / Sierra, N.A. / Avellaneda Matteo, D. / Albekioni, E. / Khoury, R. / Mai, T. / Conley, B.M. / Coleman, N.J. / Sabo, K.A. / Komives, E.A. / Bobkov, A.A. / Cooksy, A.L. / Silletti, S. / Schiffer, J.M. / Huxford, T. / Sohl, C.D. |
---|
リンク | Nat Commun / PubMed:38710674 |
---|
手法 | X線回折 |
---|
解像度 | 1.89 - 2.44 Å |
---|
構造データ | PDB-8vh9: Crystal Structure of Human IDH1 R132Q in complex with NADPH 手法: X-RAY DIFFRACTION / 解像度: 2.13 Å PDB-8vha: Crystal Structure of Human IDH1 R132Q in complex with NADPH and Alpha-Ketoglutarate 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-8vhb: Crystal Structure of Human IDH1 R132Q in complex with NADPH and Alpha-Ketoglutarate 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-8vhc: Crystal Structure of Human IDH1 R132Q in complex with NADPH 手法: X-RAY DIFFRACTION / 解像度: 2.44 Å PDB-8vhd: Crystal Structure of Human IDH1 R132Q in complex with NADPH and Isocitrate 手法: X-RAY DIFFRACTION / 解像度: 2.38 Å PDB-8vhe: Crystal Structure of Human IDH1 R132Q in Complex with NADPH-TCEP Adduct 手法: X-RAY DIFFRACTION / 解像度: 2.16 Å |
---|
化合物 | ChemComp-NDP: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / NADPH
ChemComp-EE1: (3~{S})-3-[(4~{S})-3-aminocarbonyl-1-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]-4~{H}-pyridin-4-yl]-2-oxidanylidene-pentanedioic acid
ChemComp-NAP: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
PDB-1aax: CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES
|
---|
由来 | homo sapiens (ヒト)
|
---|
キーワード | OXIDOREDUCTASE |
---|